Figure 2.
Expression of BRAFV600Ein human HSPCs induces Langerhans cell histiocytosis-like disease in MISTRG mice. Immunohistologic staining of BM, spleen, and lung of representative MISTRG mice, transplanted with Ctrl.-GFP or BRAFV600E-GFP transduced human CB HSPCs and analyzed 5 weeks later. Areas of magnification are indicated by respective squares. Scale bars represent 2 different magnifications. H&E, hematoxylin and eosin; hCD45, anti-human lymphocyte common antigen; BRAFV600E, monoclonal antibody against BRAFV600E.

Expression of BRAFV600Ein human HSPCs induces Langerhans cell histiocytosis-like disease in MISTRG mice. Immunohistologic staining of BM, spleen, and lung of representative MISTRG mice, transplanted with Ctrl.-GFP or BRAFV600E-GFP transduced human CB HSPCs and analyzed 5 weeks later. Areas of magnification are indicated by respective squares. Scale bars represent 2 different magnifications. H&E, hematoxylin and eosin; hCD45, anti-human lymphocyte common antigen; BRAFV600E, monoclonal antibody against BRAFV600E.

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