Estimated prognostic effect of NPM1 status and treatment effect. The figures show HR and 95% CI, censored at allogeneic HCT or not, for 134 FLT3-TKD mutated patients, grouped for NPM1 mutation status (mutated vs WT) (A) and according to treatment (midostaurin vs placebo) (B). The size of the boxes indicates the precision of the estimates.