(A) Subjects with clonal hematopoiesis (CH). Blue denotes recipients with their study ID (R#) and mutations (gene identifiers only) while red denote the donors with study IDs (D#) and their mutations. Donor-recipient pairs with at least one shared variant are in the center in vertical alignment. One pair (D45 and R45) both went on to develop myeloid neoplasms; the donor developed myelodysplastic syndrome with multilineage dysplasia (MDS-MLD) while the recipient developed MDS with excess blasts (MDS-EB2). The secondarily acquired variants in these two cases of MDS are highlighted in yellow. (B) Clonal evolution plots. The red color denotes the polyclonal hematopoietic stem cells (HSCs) in the donor while the blue represents a single clone which expands slightly over time. The time of HSC donation is indicated by the vertical arrow. The light blue color denotes the polyclonal HSCs in the recipient prior to HSC transplantation (HSCT), while the red is the engrafted donor cells, including the donor CH (blue). An additional subclone is shown in yellow. In other cases, the yellow clone might be a separate clone (not shown).