Two Mechanisms of Platelet Release from Bone Marrow into the Blood. The IL-1α-mediated megakaryocyte rupture mechanism on the left rapidly releases large numbers platelets into the marrow vascular sinus. The TPO-mediated pro-platelet formation mechanism on the right provides platelets at slower rates during steady-state conditions. From Nishimura S et al. J Cell Biol. 2015;209:453-466.

Two Mechanisms of Platelet Release from Bone Marrow into the Blood. The IL-1α-mediated megakaryocyte rupture mechanism on the left rapidly releases large numbers platelets into the marrow vascular sinus. The TPO-mediated pro-platelet formation mechanism on the right provides platelets at slower rates during steady-state conditions. From Nishimura S et al. J Cell Biol. 2015;209:453-466.

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