![B-cell activation (eg, via B-cell receptor [BCR] and CD40 engagement) induces the expression of dual-specificity phosphatase (DUSP4), which negatively regulates c-JUN N-terminal kinase (JNK) 1/2 by dephosphorylation, resulting in apoptosis. Inhibition of BTK and JNK1/2 acts synergistically to promote apoptosis of lymphoma cells.© Rickert R., 2015. Originally published in J Exp Med. doi:10.1084/ jem.2125insight2.](https://ash.silverchair-cdn.com/ash/content_public/journal/thehematologist/12/5/10.1182_hem.v12.5.4320/2/3dc2dc35-420f-469e-8b60-b33aa4d9177e.jpeg?Expires=1735544599&Signature=zjV10xbaify2HM664~V6bOkj8VJH4e7nhpVGFCI4XRSpFbOGY733KDZCFR3~J5~yjpX7ZKrh8XxLHuTgUD2PYoBJxWlPj1ollhJTPn9C7uLTnYt76bqd9VT0v5aPgdPT6TSD9QYV03d4VPo8RRumbElCmxqzAXiSLl~aTCotejZVLFT6W5FtCQfers6A-BKoUZgeSfCUgqYe43tnBTwzS95-Odll54LFd-c85LyfDyIklhpLPOrgVoP6xO1oZZw24i77shrZKt6Y3y~TO9bD46t1tNY5bfTHToD~hYifTYh4QdoNfm6BmISPZUVXyQ6OYZLU1TLesAZ1WobjpoIcnQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
B-cell activation (eg, via B-cell receptor [BCR] and CD40 engagement) induces the expression of dual-specificity phosphatase (DUSP4), which negatively regulates c-JUN N-terminal kinase (JNK) 1/2 by dephosphorylation, resulting in apoptosis. Inhibition of BTK and JNK1/2 acts synergistically to promote apoptosis of lymphoma cells.© Rickert R., 2015. Originally published in J Exp Med. doi:10.1084/ jem.2125insight2.
