Clonal Lineages at Diagnosis (D) and Relapse (R). Each clone is identified with a number. Mutation clusters present in each clone are marked by distinct shapes and colors. Key mutations as well as copy-number variation and structural variations in each cluster are labelled in the legend. D and R are demarcated by a vertical blue bar. Clonal population size is labelled as percentage of tumor content. The thickness of an arrow from a progenitor clone to its descendant is proportional to population change. ”Falling” clones that did not survive therapy are marked by an X.