Effects of EPHOSS on Hematopoietic Stem Cells. Hematopoietic stem cells (HSC) collected in air results in increased reactive oxygen species (ROS) production and opening of the mitochondrial permeability transition pore (MPTP) via a cyclophilin D (CypD) mediated mechanism. This oxidative stress results in lower recovery of phenotypic and functional HSCs. Conversely, the new methods of harvesting described by the authors; either in 3 percent oxygen or in the presence of the CypD inhibiting cyclosporine A, results in increased HSC recovery and transplantation.Reprinted from Cell, Vol 161/ Issue 7, Mantel CR et al, Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock, pages 1553-1565, Copyright 2015, with permission from Elsevier.

Effects of EPHOSS on Hematopoietic Stem Cells. Hematopoietic stem cells (HSC) collected in air results in increased reactive oxygen species (ROS) production and opening of the mitochondrial permeability transition pore (MPTP) via a cyclophilin D (CypD) mediated mechanism. This oxidative stress results in lower recovery of phenotypic and functional HSCs. Conversely, the new methods of harvesting described by the authors; either in 3 percent oxygen or in the presence of the CypD inhibiting cyclosporine A, results in increased HSC recovery and transplantation.Reprinted from Cell, Vol 161/ Issue 7, Mantel CR et al, Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock, pages 1553-1565, Copyright 2015, with permission from Elsevier.

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