Progression of Disease, Patient NIH075. Chronologic history of clonal evolution from the onset of disease to the last follow-up in Patient NIH075. Each mutated gene is depicted in the representative cells. The vertical axis indicates the absolute volume of the clones. Representative mutations in each clone are also shown. From Yoshizato T, Dumitriu B, Hosokawa K, et al. Somatic mutations and clonal hematopoiesis in aplastic anemia.N Engl J Med. 2015;373:35-47.