Hematopoietic Stem Cells Differentiating Into GM Cells or MegE-lineage Cells. Hematopoietic stem cells (gray) can differentiate and are annotated as committed toward the granulocytic/monocytic (GM, blue) lineage via detection of CD16/32 or toward the megakaryocytic/erythroid lineage (MegE, red) via detection of GATA1-mCherry expression. These conventional markers appear after the lineage decision of the cell (gray box).