(A) Cellular phenotype map depicting locations of PD-L1+ Hodgkin Reed-Stemberg (HRS) cells (orange dots), PD-L1+ tumor-associated macrophages (TAMs) (purple dots), and PD-L1- TAMs (pink dots). (B) Representative image (40x resolution) showing CD4+ T cells (left panel, green) with coexpression of PD-1 (right panel, yellow) touching CD68+ TAMs (both panels, magenta). Adapted from Carey CD, et al. Blood. 2017;130:2420-2430.