![The association between genotype and ALL was evaluated by using a logistic regression model for GWAS hits reported previously in B-ALL (i.e., ARID5B [rs10821936], IKZF1 [rs11978267], CDKN2A/B [rs11978267], IKZF3 [rs17607816], PIP4K2A [rs7088318], 8q24.21 [rs28665337], TP63 [rs17505102], SP4 [rs2390536], GATA3 [rs3824662], LHPP [rs35837782], ELK3 [rs4762284], CEPBE [rs2239633], and 2q22.3 [rs17481869]) or newly identified in T-ALL (i.e., USP7 [rs74010351]) in 1,191 T-ALL cases (COG AALL0434 and St. Jude Total Therapy XVI protocols) vs. 12,178 unrelated non-ALL controls (HRS), and 1,824 B-ALL cases (COGP9904/9905/9906) vs. 5,518 unrelated non-ALL controls (MESA). The locus specifically significant (P < 0.1) in T-ALL was marked in red, with B-ALL marked in blue and common marked in green. ALL, acute lymphoblastic leukemia; COG, Children’s Oncology Group; HRS, Health and Retire Study; MESA, Multi-Ethnic Study of Atherosclerosis. Reused with permission Oxford University Press, Journal of the National Cancer Institute, © 2020.](https://ash.silverchair-cdn.com/ash/content_public/journal/thehematologist/17/1/10.1182_hem.v17.1.10159/6/7c7275b6-d729-4e4e-a41b-b915685bf893.jpeg?Expires=1743234544&Signature=duLTa2AFXbO1mKTgQtloOPp3vvQKLtp5Ir9NjNszezygBntOeYImSMPFzW02~WjDq83JPfFHqw1zA~sGwRrE0xv4F7k6AoHZ~tWWFRFIfQKCVuCbtr0DdLLh3k3VhiAVTIQJA0G85UwIvY9elrSv-iApjn-Ei0FSqol02AT6HKDVlZJ~ZmNcMgMt0VhQPx2p1bwqXYtDs~SBWcNmmLGik8EZGgLdgfiqEWPcNOEOKtaPAT97uo0Z2NgE4Mot~Rvn1A2dNyTOH0R2c6Mn6h~n9T3atjegyLgjM-Q2IhOA8IRTl1HO-tMgVkSQdJGQrLj7kQsHPkY1t5-YXpsMZTIE3A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The association between genotype and ALL was evaluated by using a logistic regression model for GWAS hits reported previously in B-ALL (i.e., ARID5B [rs10821936], IKZF1 [rs11978267], CDKN2A/B [rs11978267], IKZF3 [rs17607816], PIP4K2A [rs7088318], 8q24.21 [rs28665337], TP63 [rs17505102], SP4 [rs2390536], GATA3 [rs3824662], LHPP [rs35837782], ELK3 [rs4762284], CEPBE [rs2239633], and 2q22.3 [rs17481869]) or newly identified in T-ALL (i.e., USP7 [rs74010351]) in 1,191 T-ALL cases (COG AALL0434 and St. Jude Total Therapy XVI protocols) vs. 12,178 unrelated non-ALL controls (HRS), and 1,824 B-ALL cases (COGP9904/9905/9906) vs. 5,518 unrelated non-ALL controls (MESA). The locus specifically significant (P < 0.1) in T-ALL was marked in red, with B-ALL marked in blue and common marked in green. ALL, acute lymphoblastic leukemia; COG, Children’s Oncology Group; HRS, Health and Retire Study; MESA, Multi-Ethnic Study of Atherosclerosis. Reused with permission Oxford University Press, Journal of the National Cancer Institute, © 2020.
