Kaplan-Meier curves of acute myeloid leukemia (AML)-free survival, defined as the time between sample collection and AML diagnosis, death or last follow-up. Survival curves are stratified according to mutation status for selected genes (A) or number of driver mutations per individual and largest clone detected (B). Adapted/Translated by permission from Springer Nature: Abelson S. et al. Prediction of acute myeloid leukaemia risk in healthy individuals. 2018;559:400-404.