A Model of Intravascular Hemolysis: Pathological and Adaptive Responses. Free hemoglobin can lead to pathological vasoconstriction and vasculopathy by limiting NO bioavailability and potentiating oxidative stress. An adaptive response occurs when hemoglobin is bound to haptoglobin and cleared by CD163 or heme binds to hemopexin cleared by CD91with induction of cytoprotectants including heme oxygenase-1. In turn, an anti-inflammatory/anti-oxidant response protects the vasculature.2 Copyright 2009 by American Society for Clinical Investigation. Reproduced with permission of American Society for Clinical Investigation.

A Model of Intravascular Hemolysis: Pathological and Adaptive Responses. Free hemoglobin can lead to pathological vasoconstriction and vasculopathy by limiting NO bioavailability and potentiating oxidative stress. An adaptive response occurs when hemoglobin is bound to haptoglobin and cleared by CD163 or heme binds to hemopexin cleared by CD91with induction of cytoprotectants including heme oxygenase-1. In turn, an anti-inflammatory/anti-oxidant response protects the vasculature.2 Copyright 2009 by American Society for Clinical Investigation. Reproduced with permission of American Society for Clinical Investigation.

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