Knockdown of FZD-8 Sensitizes CML Cells to Imatinib and Impairs NFAT Activity. Diagrammatic representation of the Wnt/Ca2+/NFAT pathway. Pathway details are described in the text. Reprinted from Cancer Cell, Volume 18 /Issue 1, Gregory MA, Phang TL, Neviani P, et al. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl, 74-87, Copyright (2010), with permission from Elsevier.