Figure 1.
Heterogeneity of HSPC populations in CD34-selected cord blood products by percentage and absolute number. Distribution of multipotent, myeloid-, and lymphoid-primed cell types as a percentage of CD34+ HSPCs (n = 50). (A) CD34+ cells. (B) HSCs and MPPs. (C) CMPs, GMPs, and MEPs. (D) LMPPs, MLPs, CLPs, and pro-B/NKs. (E) Distribution of total CD34+ cells, HSCs, CMPs, and CLPs by absolute number. (F) Linear regression plots to assess the putative relationship between total CD34+ cells and HSCs by percentage and absolute number (further addressed in the discussion). Immunophenotypes used to identify HSPC subtypes are defined in Table 1 and supplemental Figures 1 and 2. Each scatterplot contains 50 data points corresponding to 50 individual samples. Each data point is further indicated by a unique color and shape that remains consistent across all plots for sample tracing, with red points corresponding to 10 samples with the highest percentage of a given cell type (first quintile) and orange points corresponding to 10 samples with the lowest percentage of a given cell type (fifth quintile). Bars depict median and IQR.