Learning Objectives

  • Examine the adult experience for haploidentical stem cell transplant with PTCy and how it informs its application to pediatric patients

  • Compare survival outcomes and incidence of GVHD in pediatric regimens using PTCy to the current standard or care for GVHD prophylaxis

A 7-year-old female diagnosed with CRLF2-positive pre-B acute lymphoblastic leukemia showed persistent disease at the end of consolidation. Complete remission followed treatment with blinatumomab, and the patient is referred for stem cell transplant. There are no siblings. Donor registry search identifies a single 10/10 human leukocyte antigen matched unrelated donor (MUD), but the donor is unavailable for 2 months. Both parents are healthy and in their thirties. Who is the preferred donor? Select the unrelated donor but risk disease recurrence while waiting, or select a haploidentical parent and proceed to transplant immediately using posttransplant cyclophosphamide (PTCy)?

Hematopoietic...

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