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Mitapivat Reduces Anemia and Transfusion Burden in Thalassemia

Together, the ENERGIZE and ENERGIZE-T trials introduce the first oral therapy for thalassemia and establish the benefit of PK activation, as mitapivat led to modest improvements in anemia, fatigue, and transfusion burden. 

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The Hematologist Cover Image for Volume 22, Issue 6
Current Issue
Volume 22,
Issue 6,
November-December 2025

Featured Content

Diagnostic Oversights in Underrecognized Hemoglobin Variants

Hemoglobinopathies are among the most common inherited red blood cell disorders, yet they remain underrecognized in routine clinical practice.

Is This the Way?

Arm D of the SEQUOIA study is one of the few cohorts to evaluate the efficacy of a cBTKi and venetoclax doublet in a patient population enriched for those with p53 aberrations.

VERONA and the Future of High-Risk Myelodysplastic Syndromes

VERONA may not have delivered the patient benefit that the MDS patients, advocates, and clinicians had hoped for, but it has provided crucial insights.

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