Greenwood M, Trahair T, Sutton R, et al. An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL. Blood Adv. 2021;5(24):5574-5583.

There are errors regarding the dosing and timing of chemotherapy agents provided in Figure S1 on page 7 of supplemental File 2. These data differ from the final version of the ALL06 protocol (version 5.0, 9 June 2017) in supplemental File 1. Some omissions from the protocol have also been added to provide additional clarity. These changes do not affect the results or conclusions of the study.

Under “Protocol I: Induction,” “Daunorubicin IV 30mg/m² days 8, 15, 22, 29” should read “Daunorubicin IV 30mg/m² days 8, 16, 22, 29.”

Under “Protocol I: Consolidation,” “Cytarabine IV/SC 75mg/m² days 38-41, 45-48, 52-55, 59-62” should read “Cytarabine IV/SC 75mg/m² days 36-39, 43-46, 50-53, 57-60.”

Under “Protocol M,” “IT MTX 12mg administered on days 8, 22, 36, 50 - 2 hours after the start of MTX infusion” should be added to the schema.

Under “Protocol II: Induction,” “Doxorubicin IV 25mg/m² days 8, 15, 22, 29” should read “Doxorubicin IV 30mg/m² days 8, 15, 22, 29.”

Under “Protocol II: Consolidation,” “Cytarabine IV/SC 75mg/m² days 38-41, 45-47” should read “Cytarabine IV/SC 75mg/m² days 36-39, 43-46”; the following protocol should also be added: “IT MTX 12mg given days 36, 43.”

Under “HR Block 1,” “Cyclophosphamide IV 200mg/m² twice daily on days 2-4” should read “Cyclophosphamide IV 200mg/m² twice daily on days 2-4, total of 5 doses given every 12 hours.”

Under “HR Block 2,” “Ifosfamide IV 800mg/m² twice daily on days 2-4” should read “Ifosfamide IV 800mg/m² twice daily on days 2-4, total of 5 doses given every 12 hours,” and a citation of a new footnote (footnote f) should be added at the end of the line “IT MTX 12mg/cytarabine 30mg/hydrocortisone 50mg on day 1.” Footnote f should read “IT therapy was given on both day 1 and 5 if CNS involvement at diagnosis.”

Under “HR Block 3,” “Etoposide IV 100mg/m² twice daily on days 3-5” should read “Etoposide IV 100mg/m² twice daily on days 3-5, total of 5 doses given every 12 hours,” and “IT MTX 12mg/cytarabine 30mg/hydrocortisone 50mg on day 1” should read “IT MTX 12mg/cytarabine 30mg/hydrocortisone 50mg on day 5.”

The following text should be added at the beginning of footnote b: “IT MTX 12 mg given day 1, 18 only if CNS involvement at diagnosis.”

The corrected supplemental file is available in the HTML version of this erratum.