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First Edition

Research Article December 1 2025
Regional Brain Age is Decreased in Children with Sickle Cell Anemia
Amy E. Mirro,Landon Christian Power,Jinli Wang,Paula Germino-Watnick,Heather Roberts,Yonca Cam,Kristin Guilliams,Slim Fellah,Yasheng Chen,Hongyu An,Jin-Moo Lee,Andria L. Ford,Melanie E Fields
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Letter December 1 2025
Bioenergetic diversity and nutrient auxotrophy shape the metabolic landscape of Multiple Myeloma
Phyllis SY Chong,SL Julia Lim,Tuan Zea Tan,Li Ren Kong,Sanjay De Mel,Aaron Leow Chung Yong,Ernest Yap Gim Seng,Wee-Joo Chng
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Research Article December 1 2025
Engraftment of gene-edited hematopoietic stem cells after antibody-drug conjugate conditioning in nonhuman primates
Jason David Murray,Teresa K Einhaus,Stefan Radtke,Katharine J Bar,Christopher William Peterson,Hans-Peter Kiem
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Research Article December 1 2025
FLT3-directed BiTE Molecules versus CAR T Cells in AML: Co-stimulatory Signals Mitigate T-Cell Exhaustion
Lisa Rohrbacher,Daniel Nixdorf,Helena Stadler,Bettina Brauchle,Florian Märkl,Adrian Gottschlich,Gordon Victor Hoffmann,Nora Philipp,Gerulf Hänel,Martin Edwin Kirmaier,Anetta Marcinek,Maryam Kazerani,Daniel Richter,Giulia Magno,Rebecca L Goldstein,Sebastian Theurich,Tobias Straub,Sebastian Kobold,Tara Arvedson,Veit L. Bücklein,Marion Subklewe
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Research Article November 26 2025
Clonal hematopoiesis may precede the diagnosis of aplastic anemia by several years
Qian Wei Liu,Fang Fang,Huiwen Xue,Tove Wästerlid,Karin E. Smedby,Xinyuan Liu
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Review Article November 26 2025
Hairy Cell Leukemia: a chronic B-lymphoma with unique clinicopathological features and unresolved molecular mechanisms
Ge Zhang,Jiancheng Hu
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Research Article November 26 2025
Humoral and cellular immune response after COVID-19 vaccination in patients with sickle cell disease on hydroxyurea
Sabine Haggenburg,Cilia R. Pothast,Quincy Hofsink,Nienke J.E. Haverkate,Michel S. Bhoekhan,Mathieu Claireaux,Rob S. van Binnendijk,Gerco den Hartog,Birgit I. Lissenberg-Witte,Rory D de Vries,Charlotte F.J. Van Tuijn,Bart J. Biemond,Erfan Nur,Corine GeurtsvanKessel,Pim G.N.J. Mutsaers,Annoek E.C. Broers,Abraham Goorhuis,Inger S. Nijhof,Marit van Gils,Mirjam H.M. Heemskerk,Mette D. Hazenberg,Caroline E. Rutten
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Research Article November 26 2025
Circulating MRP8/14 drives faster platelet COX-1 recovery via MRP4 impairing the duration of aspirin response
Rossella Liani,Paola Giustina Simeone,Margherita Alfonsetti,Stefano Lattanzio,Alessia Ricci,Maurizio Frezza,Sonia Ciotti,Myriam Luongo,Francesco Cipollone,Fabio M. Pulcinelli,Francesca Santilli
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Letter November 26 2025
Ig Replacement After Bispecifics Requires Randomized Trial
Yung Gonzaga,Marcio Nucci,Elias Anaissie
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Letter November 26 2025
Fludarabine dosing in the youngest children: safety first
Rick Admiraal,Shelby Barnett,Caroline A Lindemans,Alwin D. R. Huitema,Gareth Veal
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Research Article November 25 2025
Reproducibility and repeatability of the Myoton to quantify sclerotic chronic graft-versus-host disease
Nosha Farhadfar,Najla El Jurdi,Kelsey Baker,Shramana Ghosh,Mongoljin Bat-Erdene, MPH,Heidi Chen,Ruchi Sahu,Rachel Weiss,Jerry Mi,Gabriela Desatnik,Lacey R. Williams,Eric R Tkaczyk,Stephanie J. Lee
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Review Article November 25 2025
American Society of Hematology 2025 guidelines for treating newly diagnosed acute myeloid leukemia in older adults
Mikkael A Sekeres,Ryan J Mattison,Andrew S. Artz,Maria R Baer,Chong Chyn Chua,Roberta Demichelis-Gomez,Pamela C Egan,Luke Fletcher,Charles E. Foucar,Jacqueline S. Garcia,Linda Gilberto,Andrés Gómez-De León,Jeffrey E. Lancet,Kah Poh Loh,Luca Malcovati,Bernard Lawrence Marini,Uwe Platzbecker,Mohamed L Sorror,Sara Tinsley-Vance,John Treitz,Maria Jose Oliveros,Sara Ibrahim,Yetiani Roldan,Gordon H Guyatt,Romina Brignardello-Petersen
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Research Article November 25 2025
Outcomes Following Matched Sibling Donor Transplantation for Severe Combined Immunodeficiency: A Report from the PIDTC
Ahmad Rayes,Brent R. Logan,Xuerong Liu,Jasmeen Dara,Rebecca H. Buckley,Joseph H. Oved,Neena Kapoor,Malika Kapadia,Sharat Chandra,Caridad A. Martinez,Nancy Bunin,Shanmuganathan Chandrakasan,Karin Chen,Jeffrey J Bednarski,Hilary L. Haines,Hesham Eissa,Julie-An M. Talano,Michael D. Keller,Christen L Ebens,Sonali Chaudhury,Evan B. Shereck,Victor M. Aquino,Alan P Knutsen,Jessie L Alexander,Alfred P Gillio,Deepakbabu Chellapandian,Ami J. Shah,Holly K Miller,Mark T Vander Lugt,Christine M. Seroogy,Morna J. Dorsey,Talal Mousallem,Roberta Essom Parrott,Richard J O'Reilly,Paibel I. Aguayo-Hiraldo,Susan E Prockop,Blachy J. Dávila Saldaña,Monica S. Thakar,Lauri M. Burroughs,Troy R. Torgerson,Jennifer W Leiding,Rebecca A Marsh,Linda M Griffith,Michael A. Pulsipher,Donald B. Kohn,Luigi D Notarangelo,Morton J Cowan,Jennifer M Puck,Geoffrey D.E. Cuvelier,Jennifer Heimall,Elie Haddad,Sung-Yun Pai,Christopher C Dvorak
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Research Article November 25 2025
In vivo modeling of stress erythropoiesis through targeted gene editing of rat hematopoietic stem cells
Santhe Amber van der Meulen,Karolin Roemhild,Michel Driessen,Emile van den Akker,Micha Nethe
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Letter November 25 2025
Post-transplant MRD Monitoring by TP53 Duplex Sequencing with APR-246 + Azacitidine Maintenance Predicts Outcomes
David A Sallman,Amy F McLemore,Rami S. Komrokji,Hany Elmariah,Andrew T. Kuykendall,Nelli Bejanyan,Onyee Chan,Rawan Faramand,Joseph A Pidala,Sean J Yoder,Lia E Perez,Taiga Nishihori,Eric Padron,Hugo Fernandez,Jeffrey E. Lancet,Asmita Mishra
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Research Article November 25 2025
MRD-driven Initial Therapy of Acalabrutinib and Lenalidomide plus Rituximab (ALR) or Obinutuzumab (ALO) for Mantle Cell Lymphoma
Jia Ruan,David A Bond,Bijal D Shah,John N. Allan,Sarah C. Rutherford,Caitlin Gribbin,Zhengming Chen,Bhavneet Bhinder,Wayne Tam,Davide Rossi,Jenny Z Xiang,Brittany Hobbie,Melinda Harbhajan,Tejasvi K Sahni,Gui Zhen Chen,Michael Sigouros,Giorgio GA Inghirami,Selina Chen-Kiang,Olivier Elemento,Kami J Maddocks,John P. Leonard,Peter Martin
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Research Article November 25 2025
Predictive Capacity of Peri-Transplant Measurable Residual Disease Thresholds in NPM1-Mutant Acute Myeloid Leukemia
Jan Schröder,Friederike Schwartz,Judith Metzdorf,Nick Barensteiner,Lucas Mix,Lisa-Marie Necke,Adrian Fehn,Andreas Riedel,Liv Jentzsch,Philipp Faustmann,Wichard Vogel,Wolfgang Andreas Bethge,Thomas Schroeder,Claudia Lengerke
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Research Article November 21 2025
Risk stratification of low-dose cytarabine and venetoclax in patients with AML ineligible for intensive chemotherapy
Andrew H Wei,Panayiotis Panayiotidis,Pau Montesinos,Karim Laribi,Vladimir Ivanov, MD,Inho Kim,Jan Novak,Rebecca Champion,Walter Fiedler,Maria Pagoni,Julie Bergeron, MD,Stephen B Ting,Jing-Zhou Hou, Hematology Oncology,Takahiro Yamauchi,Jianxiang Wang,Stephen A. Strickland,Michael R. Savona,Tara L. Lin,Anoop K. Enjeti,Ing Soo Tiong,Sangmin Lee,Gail J Roboz,Relja Popovic,Qi Jiang,Zihuan Liu,Yan Sun,Wellington L Mendes,Brenda Chyla,Courtney D. DiNardo
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Research Article November 21 2025
Real-World Comparative Effectiveness of Bruton Tyrosine Kinase Inhibitors in Relapsed/Refractory Mantle Cell Lymphoma
Tycel J. Phillips,Mengyang Di,Taavy Miller,Jingru Wang,Amy Pierre,Gregory A Maglinte,Erlene K Seymour,Yucai Wang
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Letter November 21 2025
National landscape of pediatric and adult inpatient sickle cell disease care
Ashley Jenkins,Spoorthy Vangala,Matthew McIntosh,Robert LeGros,Sophie Lanzkron,Kevin Fiscella
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Research Article November 21 2025
Next-generation FVIIIa-mimetic bispecific antibody NXT007: evaluation in preclinical models of hemostasis and thrombosis
Matthew Locke,Jamie Albiez,Nicolas Receveur,Sandra Marbach,Nina Frey,Mukul Girotra,Mariella Wyssenbach,Lejla Bektic,Tovo David
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Research Article November 21 2025
CHARM is Prognostic of Geriatric Morbidity and Toxicity after Allogeneic Transplant for Older Adults: BMT CTN 1704 Study
Andrew S. Artz,Brent R. Logan,Wael Saber,Nancy Geller,Anna Bellach,Jianqun Kou,William A Wood,John McCarty,Thomas G. Knight,Lyndsey Runaas,Laura Johnston,Jeremy D Walston,Ryotaro Nakamura,Asmita Mishra,Joseph Uberti,Parastoo B. Dahi,Jennifer N. Saultz,Shannon R. McCurdy,Lawrence E. Morris, Jr.,Philip Imus,William J Hogan,Kalyan V Nadiminti,Vijayaraj R. Bhatt,Rebecca L. Olin,Joseph E. Maakaron,Ronald M Sobecks,Sarah A Wall,Deborah Mattila,Bailey Protz,Steven M. Devine,Mary M Horowitz,Mohamed L Sorror
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Letter November 21 2025
Dreaming of a Better Future: Drug Development in Myeloma
Sagar Lonial,Richa Parikh
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Research Article November 19 2025
Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing
Lu Liu,Astrid Glaser,Abdulsalam I Isiaku,Kirsten Fairfax,Debora A. Casolari,Angelina Ristovski,Vincent J Murphy,Sylvie van Twest,Sarah S Henrikus,Jacki Heraud-Farlow,Elissah Granger,Stevan Novakovic,Sophie F Monks O'Byrne,Vanessa Tsui,Rachel Conyers,Thomas J Gonda,Wayne Crismani,Richard J. D'Andrea,Jörg Heierhorst,Andrew J Deans
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Research Article November 19 2025
Comprehensive analysis of complement activation in a hydroxyurea-treated sickle cell disease patient cohort
Daniel Diatlov,Arlette Bohorquez,Melanie Ann Kirby-Allen,Christoph Licht
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Research Article November 19 2025
Role of Rubicon in Platelets: A Promoter of Thrombosis but Not an Autophagy Repressor
Hammodah R. Alfar,Elizabeth R. Driehaus,Alexis N. Smith,Daniëlle Marije Coenen,Dlovan F. D Mahmood,Jeremy P. Wood,Sidney W. Whiteheart
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Letter November 19 2025
Rapid loss of viability in acute myeloid leukemia cells upon telomerase inactivation
Elisa A. Aquilanti,Lauren Kageler,Vincent Bozinov,Matthew L. Meyerson
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Letter November 19 2025
Successful engraftment in myeloablative transplant with cadaveric marrow after sudden unavailability of living donor.
Sumithira Vasu,Sarah A Wall,Karilyn Larkin,Sagar Munjal,Marcos J de Lima,Gabriela Sanchez-Petitto
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Research Article November 10 2025
Novel CSF Biomarkers for facilitating diagnosis of CNS-HLH from other Neuroinflammatory Disorders
Sharat Chandra,Kenneth D Greis,Somchai Chutipongtanate,Nathan Luebbering,Aaron Webster, MS,Kelsey Poisson,Kristen Fisher,Kristi Smiley,Rebecca A Marsh,Michael B. Jordan,Stella M Davies
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Research Article November 10 2025
A Phase I Study of Blinatumomab/Lenalidomide in Relapsed/Refractory B cell Lymphoma; Toxicity, Efficacy and Correlative Analysis
Joseph M. Tuscano,Tamer Othman,Paul Frankel, PhD,Christopher Ruel,Christina Poh,Samantha Herbert,Emanual Maverakis,Alexander A Merleev,Guillaume Luxardi,Mehrdad Abedi,Raghuveer Ranganathan,Dipenkumar Modi,Jasmine Zain,L. Elizabeth E Budde,Matthew Mei,Aaron S. Rosenberg,Rasmus T. Hoeg,Caitlin L. Costello,Francine M Foss,Basem William,H. Kent Holland,Elad Sharon,Howard Streicher,Alexey V Danilov,Edward M Newman
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Research Article November 10 2025
Proof-of-principle: Nanopore adaptive sampling enables full blood group genome analysis and resolution of hybrid alleles
Morgan Gueuning,Gian Andri Thun,Samuel Koller,Sonja Sigurdardottir,Nadine Trost,Lukas Wagner,Beate Mayer,Charlotte Engstroem,Maja Patricia Mattle-Greminger,Stefan Meyer
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Letter November 10 2025
Smoldering multiple myeloma in the United States: A population-based analysis
Shi-Yi Wang,Rong Wang,Martin Schoen,John H Huber,Eric Feuer,Jennifer Ruhl,Natalia Neparidze,Xiaomei Ma,Amy J Davidoff,Su-Hsin Chang
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Research Article November 7 2025
Racial and Clinical Determinants of Response in 2,304 r/r BCL Treated with Anti-CD19 CAR T-Cells in Clinical Trials
Soon Jye Kho,Sheila S Diamond,Penelope Lafeuille,Jonathan H Schatz,Francesco Maura,Jacob Aptekar,Frederick L Locke
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Review Article November 7 2025
Treatment of von Willebrand Disease
Nathan T Connell
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Letter November 7 2025
The Right Glucarpidose?
Marise R Heerma van Voss,Maaike A Sikma,Frederike K Engels,Anita W Rijneveld,Marieke A Dijkman,Arjen Koppen,Martine E.D. Chamuleau,Imke H Bartelink
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Research Article November 7 2025
Clinical Trial Success Rate in Lymphoma: Fate of Trials and Agents from 2000 to 2019
Zhiping Luo,Meng Li,Brian Primeaux,Rahul Shah,Ruitao Lin,Swaminathan P. Iyer,Loretta J. Nastoupil,Michael R Green,Jason R Westin,Christopher R Flowers,Dai Chihara
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Research Article November 7 2025
Novel humanized loss-of-function NF1 mouse model of juvenile myelomonocytic leukemia
Roshani Sinha,Rachana V Patil,Rosa Romano,Devesh Sharma,Esmond Lee,Rhonda Perriman,Saori Takeda,Benjamin J Lesch,Zhenyu Yao,Y. Lucy Liu,M. Kyle Cromer,Matthew H Porteus,Alice Bertaina
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Research Article November 7 2025
Outcomes for CART as 2L vs 3L vs 4L or Beyond in Aggressive B-cell Lymphoma: Real World Evidence from the ABC Consortium
John Seng Wang,Brandon Lee Ellsworth,Megan Melody,Narendranath Epperla,Deborah M Stephens,Jason T. Romancik,Matthew J. Cortese,Rahul S Bhansali,Tamara K Moyo,Vaishalee P Kenkre,Thomas A Ollila,Brian T Hess,Lindsey A. Fitzgerald,Geoffrey Shouse,Matthew J. Matasar,Megan M. Herr,James A Davis,Christy Jesme,Ari Pelcovits,Jonathan Moreira,Adam Yuh Lin,Shuo Ma,Jane N Winter,Alexey V Danilov,Nirav N Shah,Stefan K. Barta,Jonathon B Cohen,Leo I. Gordon,Natalie S. Grover,Reem Karmali
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Research Article November 5 2025
UBE2O AS A KEY REGULATOR OF DRUG-INDUCED ERYTHROPOIESIS IN THE CONTEXT OF MYELODYSPLASTIC SYNDROMES
Beatrice Maffeo,Cristina Panuzzo,Arianna Savi,Federico Itri,Simone Piccioli,Alice Costanza Danzero,Alessandro Maglione,Silvia Marini,Maria Teresa Voso,Carmen Fava,Enrico Bracco,Barbara Pergolizzi,Daniela Cilloni
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Research Article November 5 2025
Bleeding and Thrombotic Outcomes in Patients With Inflammatory Bowel Disease and Venous Thromboembolism
Ghadeer K. Dawwas,Adam Cuker,James D. Lewis
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Research Article November 5 2025
Dynamic activity of Erg promotes maturation of the hematopoietic system
Mayuri Tanaka-Yano,Wade Sugden,Dahai Wang,Marcelo Falchetti,Brianna Badalamenti,Parker Côté,Diana H Chin,Julia Goldstein,Stephan George,Gabriela Flavia Rodrigues-Luiz,Edroaldo Lummertz da Rocha,Hojun Li,Trista North,Berkley E. Gryder,Robert Grant Rowe
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Research Article November 5 2025
Dietary animal fat disrupts gut microbiota and aggravates Scl-cGVHD after allogeneic hematopoietic stem cell transfer
Danielle D Millick,Shreya Ghosh,Guojun Wu,Agata Karolina Krzyzanowska,Louis J Osorio,Liping Zhao,Roger Strair,Derek B Sant'Angelo
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Letter November 5 2025
Hypoxia-inducible Factors Contribute to Venous Thrombosis in a Mouse Model of Myeloproliferative Neoplasms
Shatadal Ghosh,Joanna Miklosz,Fatima Trebak,Julie Tourn,Steven P Grover,Rafal Pawlinski,Brandi N. Reeves
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Research Article November 5 2025
Diagnostic Criteria for NK-Cell Large Granular Lymphocyte Leukemia: Validation Through a Multicentric International Study
Cedric Pastoret,Jun Yang,David J. Feith,Mikael Roussel,Aline Moignet,Shubha Dighe,Micheal Dimitri Solga,Tony Marchand,Garance Visser,Vanessa Rebecca Gasparini,Antonella Teramo,Renato Zambello,Thomas P Loughran,Thierry Lamy
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Letter November 5 2025
Long-term Remission After Cilta-Cel in Multiple Myeloma Is Linked to Diverse T Cells and Low Myeloid Suppression
Junia Vieira dos Santos,David T Melnekoff,Adolfo Aleman,Tarek H Mouhieddine,Rocio Montes de Oca,Feng Wang,Sridevi Rajeeve,Sherry Bhalla,Oliver Van Oekelen,Bhaskar Upadhyaya,Yogita Ghodke-Puranik,Violetta V Leshchenko,Seunghee Kim-Schulze,Adeeb Habibur Rahman,Shaked Afik,Hadas Lewinsky,Vicki Plaks,Santiago Thibaud,Hearn Jay Cho,Joshua Richter,Cesar Rodriguez,Larysa J Sanchez,Adriana C Rossi,Shambavi Richard,Ajai Chari,Deepu Madduri,Sundar Jagannath,Samir Parekh,Alessandro Lagana
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Research Article October 31 2025
Metformin induces ferroptosis associated with lipidomic remodeling in AML
Dominique Sternadt,Diego A Pereira-Martins,Prodromos Chatzikyriakou,Luise Albuquerque-Simões,Ming Yang,Douglas R Silveira,Albertus TJ Wierenga,Isabel Weinhäuser,Shanna M. Hogeling,Lieve Oudejans,Pilar Casares-Alaez,Jean-Emmanuel Sarry,Christian Frezza,Gerwin A Huls,Lynn Quek,Jan Jacob Schuringa
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Letter October 31 2025
Long-term Efficacy and Safety of Ropeginterferon Alfa-2b under its HIDAT Regimen for the Treatment of Polycythemia Vera
Shanshan Suo,Rongfeng Feng Fu,Albert Qin, Dr.,Zonghong Shao,Jie Bai,Hu Zhou,Na Xu,Suning Chen,Xuelan Zuo,Xin Du,Minghui Duan,Li Wang,Pei Li,Xuhan Zhang,Sujiang Zhang,Daoxiang Wu,Jingjing Zhang,Zhijian Xiao,Lei Zhang,Jie Jin
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Research Article October 31 2025
No clear benefit of cellular therapy consolidation for patients achieving remission after post-HCT AML relapse
H. Moses Murdock,Haesook T Kim,Katie Maurer,Amar H. Kelkar,Roman M Shapiro,Mahasweta Gooptu,Rizwan Romee,Prashant K Nageshwar,Heather M Garrity,Shai Shimony,Marlise R. Luskin,Eric S. Winer,Rahul S. Vedula,Maximilian F. Stahl,Evan C. Chen,Virginia O. Volpe,Jacqueline S. Garcia,Martha Wadleigh,Daniel J. DeAngelo,Richard M. Stone,Catherine J Wu,Corey S. Cutler,John Koreth,Jerome Ritz,Joseph H Antin,Vincent T. Ho,Sarah Nikiforow,Robert J. Soiffer
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Research Article October 30 2025
A Retrospective Study of Treatment and Outcomes in Synchronous Systemic and Central Nervous System Large B-cell Lymphoma
J. Erika Haydu,Robert A Redd,Matthew M Lei,Ephraim Hochberg,Jeffrey A. Barnes,Philippe Armand,Jacob D Soumerai,April Eichler,Eric D. Jacobsen,Justin T. Jordan,Caron A. Jacobson,Ann S. LaCasce,Isabel C Arrillaga-Romany,J.R. McFaline-Figueroa,Scott R. Plotkin,Ronald W. Takvorian,Ugonma Nnenna Chukwueke,Jennifer L. Crombie,P. Connor Johnson,Philipp Karschnia,Jörg Dietrich,Lakshmi Nayak,Jeremy S. Abramson
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Letter October 30 2025
Accurate and reliable detection of clonal hematopoiesis in plasma cell-free DNA
Alyssa C. Parker,Joseph Van Amburg,Yash Pershad,David A Ong,Ketan J Hoey,Christopher J. Farady,Philipp J Rauch,Michael M Mendelson,J Brett Heimlich,Paul Brent Ferrell, Jr.,Alexander G. Bick
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