Skip to Main Content

Advertisement intended for health care professionals

Umbrella Alt Text
Cart
header search
Search
Skip Nav Destination

Issue Archive

Volume 9, Issue 5
March 11 2025
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Ubiquitous clot contraction blockers hit ubiquitin and more
John W. Weisel,Rustem I. Litvinov
View Articletitled, Ubiquitous clot contraction blockers hit ubiquitin and more
Consensus in CLL: global needs matter
Clinical Trials & Observations
Mazyar Shadman,Bita Fakhri,Nitin Jain
View Articletitled, Consensus in CLL: global needs matter
CAR T-cell reality for R/R LBCL: challenges and challengers
Clinical Trials & Observations
Paolo F. Caimi,Craig S. Sauter
View Articletitled, CAR T-cell reality for R/R LBCL: challenges and challengers

ADVANCES VIEWPOINT

Advancing drug development in myelodysplastic syndromes
Clinical Trials & Observations
Alain Mina,Kathy L. McGraw,Lea Cunningham,Nina Kim,Emily Y. Jen,Katherine R. Calvo,Lori A. Ehrlich,Peter D. Aplan,Guillermo Garcia-Manero,James M. Foran,Jacqueline S. Garcia,Amer M. Zeidan,Amy E. DeZern,Rami Komrokji,Mikkael A. Sekeres,Bart Scott,Rena Buckstein,Sara Tinsley-Vance,Amit Verma,Tanya Wroblewski,Steven Pavletic,Kelly Norsworthy
View Articletitled, Advancing drug development in myelodysplastic syndromes
Consensus recommendations from the 2024 Lymphoma Research Foundation workshop on treatment selection and sequencing in CLL or SLL
Clinical Trials & Observations
Jacob D. Soumerai,Jacqueline Barrientos,Inhye Ahn,Catherine Coombs,Douglas Gladstone,Marc Hoffman,Adam Kittai,Ryan Jacobs,Andrew Lipsky,Krish Patel,Joanna Rhodes,Alan Skarbnik,Meghan Thompson,Daniel Ermann,Patrick Reville,Harsh Shah,Jennifer R. Brown,Deborah M. Stephens
View Articletitled, Consensus recommendations from the 2024 Lymphoma Research Foundation workshop on treatment selection and sequencing in CLL or SLL
Supplemental data
Consensus in CLL: global needs matter
Clinical Trials & Observations
Mazyar Shadman,Bita Fakhri,Nitin Jain
View Articletitled, Consensus in CLL: global needs matter

CLINICAL TRIALS AND OBSERVATIONS

Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Clinical Trials & Observations
Mark C. Walters,Mary Eapen,Yiwen Liu,Fuad El Rassi,Edmund K. Waller,John E. Levine,John J. Strouse,Joseph H. Antin,Suhag H. Parikh,Nitya Bakshi,Carlton Dampier,Jennifer J. Jaroscak,Shayla Bergmann,Trisha Wong,Vamsi Kota,Betty Pace,Lazaros J. Lekakis,Premal Lulla,Robert S. Nickel,Kimberly A. Kasow,Uday Popat,Wally Smith,Lolie Yu,Nancy DiFronzo,Nancy Geller,Naynesh Kamani,Elizabeth S. Klings,Kathryn Hassell,Adam Mendizabal,Keith Sullivan,Donna Neuberg,Lakshmanan Krishnamurti
View Articletitled, Hematopoietic cell transplant compared with standard care in adolescents and young adults with sickle cell disease
Supplemental data
Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B
Clinical Trials & Observations
Steven W. Pipe,Toshko Lissitchkov,Pencho Georgiev,Sarah Mangles,Inga Hegemann,Alice Trinchero,Pratima Chowdary,Adam Forbes,Liqi Feng,Laurel A. Menapace,Salim Kichou,Shauna Andersson,Marek Demissie,Margaret V. Ragni
View Articletitled, Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B
Supplemental data
Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma
Clinical Trials & Observations
Andrew J. Yee,Jacob P. Laubach,Erica L. Campagnaro,Brea C. Lipe,Omar Nadeem,Robb S. Friedman,Craig E. Cole,Elizabeth K. O’Donnell,Giada Bianchi,Andrew R. Branagan,Robert L. Schlossman,Samantha J. Shapiro,Cynthia C. Harrington,Jill N. Burke,Marilyn T. Gammon,Kathleen J. Lively,Cassandra A. Reimonn,Danielle X. Andrade,Robert Redd,Jens G. Lohr,Kenneth C. Anderson,Paul G. Richardson,Noopur S. Raje
View Articletitled, Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma
Supplemental data
Lisocabtagene maraleucel for relapsed/refractory large B-cell lymphoma: a cell therapy consortium real-world analysis
Clinical Trials & Observations
Peter A. Riedell,Connor B. Grady,Loretta J. Nastoupil,Alejandro Luna,Nausheen Ahmed,Richard T. Maziarz,Marie Hu,Jamie Brower,Wei-Ting Hwang,Stephen J. Schuster,Andy I. Chen,Olalekan O. Oluwole,Veronika Bachanova,Joseph P. McGuirk,Miguel-Angel Perales,Michael R. Bishop,David L. Porter
View Articletitled, Lisocabtagene maraleucel for relapsed/refractory large B-cell lymphoma: a cell therapy consortium real-world analysis
Supplemental data
CAR T-cell reality for R/R LBCL: challenges and challengers
Clinical Trials & Observations
Paolo F. Caimi,Craig S. Sauter
View Articletitled, CAR T-cell reality for R/R LBCL: challenges and challengers

LYMPHOID NEOPLASIA

Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium
Jonathan R. Day,Melissa C. Larson,Urshila Durani,Jean L. Koff,Yucai Wang,Thomas M. Habermann,Izidore S. Lossos,Loretta J. Nastoupil,Christopher Strouse,Dai Chihara,Peter Martin,John P. Leonard,Jonathon B. Cohen,Brad S. Kahl,Jia Ruan,W. Richard Burack,Jonathan W. Friedberg,James R. Cerhan,Christopher R. Flowers,Brian K. Link,Matthew J. Maurer,Carla Casulo
View Articletitled, Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium
Supplemental data
Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma
Clinical Trials & Observations
Huimin Geng,Shirley Mo,Lingjing Chen,Aishwarya Ballapuram,Mazie Tsang,Ming Lu,Andreas M. Rauschecker,Kwun Wah Wen,Walter Patrick Devine,David A. Solomon,James L. Rubenstein
View Articletitled, Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma
Supplemental data

MYELOID NEOPLASIA

Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies
Melissa Zhao,Scott Ryall,Samuel J. Brody,Amyah C. Harris,Kristin Cabral,Catherine Brownstein,Jaeseung C. Kim,Adam C. Smith,Paola Dal Cin,Rupa Narayan,Kristin Sikkink,Anthony Schmitt,Gabriela S. Hobbs,Amir T. Fathi,Gabriel K. Griffin,Sheila N. J. Sait,Anthony J. Iafrate,Jon C. Aster,Timothy A. Graubert,Valentina Nardi,Adrian M. Dubuc
View Articletitled, Integrative cytogenetic and molecular studies unmask “chromosomal mimicry” in hematologic malignancies
Supplemental data
Advantages of a genomic DNA-based next-generation sequencing assay for detection of mutant NPM1 measurable residual disease in AML
Christian M. Vonk,Tim Grob,Melissa Rijken,François G. Kavelaars,Jolinda M. L. Konijnenburg,Gert J. Ossenkoppele,Markus G. Manz,Violaine Havelange,Yngvar Fløisand,Bob Löwenberg,Peter J. M. Valk
View Articletitled, Advantages of a genomic DNA-based next-generation sequencing assay for detection of mutant <em>NPM1</em> measurable residual disease in AML
Supplemental data
Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML
Nam H. K. Nguyen,Roya Rafiee,Phani K. Parcha,Abderrahmane Tagmount,Jeffrey Rubnitz,Raul Ribeiro,Xueyuan Cao,Stanley B. Pounds,Christopher D. Vulpe,Jatinder K. Lamba
View Articletitled, Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML
Supplemental data
Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study
Vikas Gupta,Ciprian Tomuleasa,Gilberto Israel Barranco Lampón,Hsin-An Hou,Grzegorz Helbig,Pankit Vachhani,Argiris Symeonidis,Ibrahim Haznedaroglu,Kenny Galvez,Fernando Tatsch,Avijeet S. Chopra,Meng Zhang,Tamas Vizkelety,Bryan Murray,David M. Ross
View Articletitled, Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study
Supplemental data

PLASMA CELL DISORDERS

NAD+ metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma
Debora Soncini,Pamela Becherini,Francesco Ladisa,Silvia Ravera,Adithya Chedere,Elisa Gelli,Giulia Giorgetti,Claudia Martinuzzi,Francesco Piacente,Luca Mastracci,Claudia Veneziano,Gianluca Santamaria,Fiammetta Monacelli,Moustafa S. Ghanem,Antonia Cagnetta,Fabio Guolo,Matteo Garibotto,Sara Aquino,Mario Passalaqua,Santina Bruzzone,Axel Bellotti,Michel A. Duchosal,Aimable Nahimana,Emanuele Angelucci,Chandra Nagasuma,Alessio Nencioni,Roberto Massimo Lemoli,Michele Cea
View Articletitled, NAD<sup>+</sup> metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma
Supplemental data
Cumulative deficits frailty index and relationship status predict survival in multiple myeloma
Nadine Abdallah,Paul Dizona,Amanika Kumar,Betsy LaPlant,Terri Menser,Gavin Schaeferle,Sarah Aug,Megan Weivoda,Angela Dispenzieri,Francis K. Buadi,Rahma Warsame,Joselle Cook,Martha Q. Lacy,Suzanne Hayman,Morie A. Gertz,S. Vincent Rajkumar,Shaji K. Kumar
View Articletitled, Cumulative deficits frailty index and relationship status predict survival in multiple myeloma
Supplemental data
BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement
Mahmoud R. Gaballa,Omar Castaneda Puglianini,Adam Cohen,Dan Vogl,Alfred Chung,Christopher J. Ferreri,Peter Voorhees,Doris K. Hansen,Krina K. Patel
View Articletitled, BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement

PLATELETS AND THROMBOPOIESIS

Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling
Maksym A. Jopek,Michał Sieczczyński,Krzysztof Pastuszak,Sylwia Łapińska-Szumczyk,Jacek Jassem,Anna J. Żaczek,Matthew T. Rondina,Anna Supernat
View Articletitled, Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling
Supplemental data
Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction
Lorena Buitrago,Miriam-Rose Menezes,Chloe Larson,Jihong Li,Thomas Kartika,Priyam Banerjee,Fraser Glickman,Barry Coller
View Articletitled, Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction
Supplemental data
Ubiquitous clot contraction blockers hit ubiquitin and more
John W. Weisel,Rustem I. Litvinov
View Articletitled, Ubiquitous clot contraction blockers hit ubiquitin and more
α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment
Xiangjie Lin,Hanchen Gao,Min Xin,Jian Huang,Xia Li,Yutong Zhou,Keyu Lv,Xin Huang,Jinghan Wang,Yulan Zhou,Dawei Cui,Chao Fang,Lanlan Wu,Xiaofeng Shi,Zhixin Ma,Yu Qian,Hongyan Tong,Jing Dai,Jie Jin,Jiansong Huang
View Articletitled, α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment
Supplemental data

TRANSPLANTATION

Antiviral potential of Vδ2 T cells in children given TCR αβ/CD19 cell-depleted HLA-haploidentical HSCT
Veronica Bordoni,Federica Guarracino,Federica Galaverna,Valentina Bertaina,Giuseppina Li Pira,Marco Rosichini,Angela Pitisci,Giulia Matusali,Fabrizio Maggi,Enrico Velardi,Pietro Merli,Franco Locatelli,Chiara Agrati
View Articletitled, Antiviral potential of Vδ2 T cells in children given TCR αβ/CD19 cell-depleted HLA-haploidentical HSCT
Supplemental data
Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis
Joseph Pidala,Jongphil Kim,Denise Kalos,Corey Cutler,Zachariah DeFilipp,Mary E. D. Flowers,Betty K. Hamilton,Kuo-Kai Chin,Marcello Rotta,Najla El Jurdi,Mehdi Hamadani,Gulrayz Ahmed,Carrie Kitko,Doris Ponce,Anthony Sung,Helen Tang,Nosha Farhadfar,Eneida Nemecek,Iskra Pusic,Muna Qayed,Hemalatha Rangarajan,William Hogan,Aaron Etra,Samantha Jaglowski
View Articletitled, Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis
Supplemental data
Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma
Nadeem Tabbara,Marianna Zahurak,Cole H. Sterling,Iris Margalit Trutzer,Jaroslaw Jedrych,Lode J. Swinnen,Ephraim J. Fuchs,Javier Bolaños-Meade,Nina Wagner-Johnston,Richard J. Jones,Richard F. Ambinder,Ravi Varadhan,Suman Paul
View Articletitled, Improved overall survival with checkpoint inhibition and allogeneic transplantation in relapsed Hodgkin lymphoma
Supplemental data

VASCULAR BIOLOGY

Physiological significance of antithrombin D-helix interaction with vascular GAGs
Indranil Biswas,Sumith R. Panicker,Florea Lupu,Alireza R. Rezaie
View Articletitled, Physiological significance of antithrombin D-helix interaction with vascular GAGs
Supplemental data

RESEARCH LETTERS

Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma
Clinical Trials & Observations
Johannes M. Waldschmidt,Noori Sotudeh,Sankalp Arora,Tushara Vijaykumar,Praveen Anand,Hannah Stuart,Julia Frede,Tim Campbell,Shari M. Kaiser,Xirong Zheng,Nikhil C. Munshi,Kenneth C. Anderson,Hermann Einsele,Andrew J. Yee,Birgit Knoechel,Jens G. Lohr,Noopur S. Raje
View Articletitled, Nivolumab to restore T-cell fitness in CAR-T refractory multiple myeloma
Supplemental data
Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report
Clinical Trials & Observations
Xiaoyuan He,Xiaomei Zhang,Zhengyu Yu,Juanxia Meng,Yanyu Jiang,Yifan Zhao,Hairong Lyu,Xue Bai,Xia Xiao,Mingfeng Zhao
View Articletitled, Anti-FcRL5 CAR-T exhibits anti-MM activity against EMM after progression of anti-BCMA and anti-GPRC5D CAR-T: a case report
Supplemental data
Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A
Karina Althaus,Sophie Kieninger,Anna Bäuerle,Stefanie Hammer,Nina Wolska,Günalp Uzun,Karoline Weich,Lorenzo Alberio,Alessandro Aliotta,Christoph Faul,Margarete Moyses,Ursula Holzer,Vanya Icheva,David Gorodezki,Sebastian Hörber,Susan Halimeh,Jan Zlamal,Tamam Bakchoul
View Articletitled, Platelet potential to switch to procoagulant phenotype compensates bleeding tendency in patients with hemophilia A
Supplemental data

LETTER TO THE EDITOR

Pediatric refractory ITP, a definition to be defined
Emilia Parodi,Giovanna Russo
View Articletitled, Pediatric refractory ITP, a definition to be defined

RESPONSE

Working toward international consensus defining pediatric “refractory ITP”
Candelaria O’Farrell,Amanda Bell Grimes,Taizo A. Nakano,Robert J. Klaassen,Michele P. Lambert,Cindy Neunert,Jennifer A. Rothman,Kristin A. Shimano,Rachael F. Grace
View Articletitled, Working toward international consensus defining pediatric “refractory ITP”
  • Cover Image

    Cover Image

    issue cover

    Pattern of HLA-DR expression in a diagnostic specimen of primary central nervous system lymphoma with copy-neutral loss of heterozygosity at chromosome 6p. In situ hybridization demonstrates expression of HLA-DR (red) by infiltrating macrophages but not lymphoma cells (large nuclei [DAPI, 4’,6-diamidino-2-phenylindole; blue]). In situ hybridization confirmed colocalization of HLA-DR with CD68 and macrophages but not with CD20+ lymphoma cells (not shown). See the article by Geng et al.

All Issues

Advertisement intended for health care professionals

VWF-ADAMTS13 imbalance bridges infection to stroke
Predicting risk in Hodgkin lymphoma for research and clinical practice
Pediatric relapsed/refractory ALK-positive anaplastic large cell lymphoma treatment and outcomes in the targeted-drug era
Nivolumab and rituximab in treatment-naïve follicular lymphoma: the phase 2 1st FLOR study
Clinical use of measurable residual disease in adult ALL: recommendations from a panel of US experts

Advertisement intended for health care professionals

Advertisement intended for health care professionals

  • American Society of Hematology
  • 2021 L Street NW, Suite 900
  • Washington, DC 20036
  • TEL +1 202-776-0544
  • FAX +1 202-776-0545

ASH Publications

American Society of Hematology

Copyright 2024 by American Society of Hematology
 
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal

Advertisement intended for health care professionals