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Issue Archive

Volume 9, Issue 3
February 11 2025
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

IDCH: is it now determined?
Clinical Trials & Observations
Nitya Gulati,Jennifer Picarsic
View Articletitled, IDCH: is it now determined?
PETAL: a global view on R/R T-/NK-lymphoma treatment reality
Clinical Trials & Observations
Qu Jiang,Marco Herling
View Articletitled, PETAL: a global view on R/R T-/NK-lymphoma treatment reality
Caregiver signaling questions in sickle cell disease
Jeffrey Schatz,Alyssa M. Schlenz
View Articletitled, Caregiver signaling questions in sickle cell disease
PTCy unchained in matched siblings: the D is silent in GVHD
Nico Gagelmann,Anant Vatsayan
View Articletitled, PTCy unchained in matched siblings: the D is silent in GVHD

CLINICAL TRIALS AND OBSERVATIONS

MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma
Clinical Trials & Observations
Manisha Bhutani,Myra Robinson,David Foureau,Shebli Atrash,Barry Paul,Fei Guo,Jason M. Grayson,Anna Ivanina-Foureau,Mauricio Pineda-Roman,Cindy Varga,Reed Friend,Christopher J. Ferreri,Xhevahire Begic,Sarah Norek,Tiffany Drennan,Michelle B. Anderson,James T. Symanowski,Peter M. Voorhees,Saad Z. Usmani
View Articletitled, MRD-driven phase 2 study of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma
Supplemental data
Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia
Clinical Trials & Observations
Marlise R. Luskin,Shai Shimony,Julia Keating,Eric S. Winer,Jacqueline S. Garcia,Richard M. Stone,Elias Jabbour,Yael Flamand,Kristen Stevenson,Jeremy Ryan,Zhihong Zeng,Anthony Letai,Marina Konopleva,Nitin Jain,Daniel J. DeAngelo
View Articletitled, Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia
Supplemental data

HEALTH SERVICES AND OUTCOMES

Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease
Christina M. Dandar,Lakia Kearson,Jennifer N. Longoria,Brian Potter,Allison A. King,Jeffrey Gossett,Clifford M. Takemoto,Jane S. Hankins,Guolian Kang,Andrew M. Heitzer
View Articletitled, Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease
Supplemental data
Caregiver signaling questions in sickle cell disease
Jeffrey Schatz,Alyssa M. Schlenz
View Articletitled, Caregiver signaling questions in sickle cell disease

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans
Hugues Allard-Chamard,Kirsty Hillier,Michelle L. Ramseier,Alice Bertocchi,Naoki Kaneko,Katherine Premo,Grace Yuen,Marshall Karpel,Vinay S. Mahajan,Christina Tsekeri,Joseph S. Hong,Jean Vencic,Rory Crotty,Anish V. Sharda,Sara Barmettler,Emma Westermann-Clark,Jolan E. Walter,Musie Ghebremichael,Alex K. Shalek,Jocelyn R. Farmer,Shiv Pillai
View Articletitled, Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans
Supplemental data
Development and validation of predictive models of early immune effector cell–associated hematotoxicity
Emily C. Liang,Jennifer J. Huang,Andrew J. Portuguese,Valentín Ortiz-Maldonado,Aya Albittar,Natalie Wuliji,Ryan Basom,Yein Jeon,Qian Wu,Aiko Torkelson,Delaney Kirchmeier,Abigail Chutnik,Barbara Pender,Mohamed Sorror,Joshua A. Hill,Noam E. Kopmar,Rahul Banerjee,Andrew J. Cowan,Damian Green,Ajay K. Gopal,Christina Poh,Mazyar Shadman,Alexandre V. Hirayama,Brian G. Till,Erik L. Kimble,Lorenzo Iovino,Aude G. Chapuis,Folashade Otegbeye,Ryan D. Cassaday,Filippo Milano,Cameron J. Turtle,David G. Maloney,Jordan Gauthier
View Articletitled, Development and validation of predictive models of early immune effector cell–associated hematotoxicity
Supplemental data

LYMPHOID NEOPLASIA

A real-world comparison of commercial-use axicabtagene ciloleucel and lisocabtagene maraleucel in large B-cell lymphoma
Andrew Looka,David A. Qualls,Daniel Matthews,Robert A. Redd,Christopher Sakellis,Caitlyn Duffy,Jamie Dela Cruz,Anna Saucier,Philippe Armand,Jennifer L. Crombie,David C. Fisher,Eric D. Jacobsen,Austin I. Kim,Ann S. LaCasce,Reid W. Merryman,Erin M. Parry,Caron A. Jacobson
View Articletitled, A real-world comparison of commercial-use axicabtagene ciloleucel and lisocabtagene maraleucel in large B-cell lymphoma
Supplemental data
Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models
Sankaranarayanan Kannan,Yizhen Li,Natalia Baran,Xu Yang,Sanaz Ghotbaldini,Qi Zhang Tatarata,Satoshi Yoshimura,Zhenhua Li,YuChih Hsiao,Srividya Balachander,Courtney L. Andersen,Justin Cidado,Jiyang Yu,Nitin Jain,Jun J. Yang,Marina Konopleva
View Articletitled, Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models
Supplemental data
PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma
Genevieve Douglas,Zoe Loh,Evonne S.Y. Shum,Sze-Ting Lee,Niamh Waters,Garry Hamilton,Geoffrey Chong,Alexandra C. Murphy,Eliza A. Hawkes
View Articletitled, PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma
Supplemental data
Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium
Clinical Trials & Observations
Jessy Xinyi Han,Min Jung Koh,Leora Boussi,Mark Sorial,Sean M. McCabe,Luke Peng,Shambhavi Singh,Ijeoma Julie Eche-Ugwu,Judith Gabler,Maria J. Fernandez Turizo,Caroline T. MacVicar,Aditya Garg,Alexander Disciullo,Kusha Chopra,Alexandra Lenart,Emmanuel Nwodo,Jeffrey Barnes,Min Ji Koh,Eliana Miranda,Carlos Chiattone,Robert Stuver,Steven M. Horwitz,Mwanasha Merrill,Eric Jacobsen,Martina Manni,Monica Civallero,Tetiana Skrypets,Athina Lymboussaki,Massimo Federico,Yuri Kim,Jin Seok Kim,Jae Yong Cho,Thomas Eipe,Tanuja Shet,Epari Sridhar,Alok Shetty,Saswata Saha,Hasmukh Jain,Manju Sengar,Carrie Van Der Weyden,Henry Miles Prince,Ramzi Hamouche,Tinatin Murdashvili,Francine Foss,Marianna Gentilini,Beatrice Casadei,Pier Luigi Zinzani,Takeshi Okatani,Noriaki Yoshida,Sang Eun Yoon,Won-Seog Kim,Girisha Panchoo,Zainab Mohamed,Estelle Verburgh,Jackielyn Cuenca Alturas,Mubarak Al-Mansour,Josie Ford,Maria Elena Cabrera,Amy Ku,Govind Bhagat,Helen Ma,Ahmed Sawas,Khyati Maulik Kariya,Makoto Iwasaki,Forum Bhanushali,Owen A. O’Connor,Enrica Marchi,Changyu Shen,Devavrat Shah,Salvia Jain
View Articletitled, Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium
Supplemental data
PETAL: a global view on R/R T-/NK-lymphoma treatment reality
Clinical Trials & Observations
Qu Jiang,Marco Herling
View Articletitled, PETAL: a global view on R/R T-/NK-lymphoma treatment reality
Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells
Anthony M. Battram,Joan Mañé-Pujol,David F. Moreno,Aina Oliver-Caldés,Judit Carpio,Oriol Cardus,Luis Gerardo Rodríguez-Lobato,Álvaro Urbano-Ispizua,Carlos Fernández de Larrea
View Articletitled, Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells
Supplemental data

MYELOID NEOPLASIA

Diagnosis of TP53-mutated myeloid disease by the ICC and WHO fifth edition classifications
Stephanie A. Hart,Laura A. Lee,Adam C. Seegmiller,Emily F. Mason
View Articletitled, Diagnosis of <em>TP53</em>-mutated myeloid disease by the ICC and WHO fifth edition classifications
Supplemental data
RAPID-CRISPR: highly sensitive diagnostic assay for detection of PML::RARA isoforms in acute promyelocytic leukemia
Akash Maity,Amritha Sathyanarayanan,Rohit Kumar,Jesal Vora,Jitendra Gawde,Hasmukh Jain,Bhausaheb Bagal,P. G. Subramanian,Manju Sengar,Navin Khattry,Nikhil Patkar,Syed K. Hasan
View Articletitled, RAPID-CRISPR: highly sensitive diagnostic assay for detection of <em>PML::RARA</em> isoforms in acute promyelocytic leukemia
Supplemental data
Evolving racial/ethnic disparities in AML survival in the novel therapy era
Clinical Trials & Observations
Xin Wang,Phyllis A. Gimotty,Andrew H. Matthews,Ronac Mamtani,Selina M. Luger,Elizabeth O. Hexner,Daria V. Babushok,Shannon R. McCurdy,Noelle V. Frey,Ximena Jordan Bruno,Saar Gill,Mary Ellen Martin,Vikram R. Paralkar,Ivan Maillard,David L. Porter,Alison W. Loren,Alexander E. Perl,Keith W. Pratz,Kelly D. Getz,Catherine Lai
View Articletitled, Evolving racial/ethnic disparities in AML survival in the novel therapy era
Supplemental data

PLASMA CELL DISORDERS

Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma
Inés Zugasti,Marta Tormo-Ratera,Aina Oliver-Caldés,Juan Carlos Soler-Perromat,Verónica González-Calle,David F. Moreno,Valentín Cabañas,Nieves López-Muñoz,Álvaro Bartolomé-Solanas,Marta Español-Rego,Juan Luis Reguera-Ortega,Laura Rosiñol,Lucía López-Corral,Natalia Tovar,Luis Gerardo Rodríguez-Lobato,Rosa Maria Alvarez Perez,Sara Varea,Eulàlia Olesti,Adolfo Gomez-Grande,Laura Frutos,Pilar Tamayo,Manel Juan,José M. Moraleda,Álvaro Urbano-Ispizua,E. Azucena González-Navarro,Joaquín Martínez-López,Maria-Victoria Mateos,Xavier Tomás,Xavier Setoain,Carlos Fernández de Larrea
View Articletitled, Clinical impact of [<sup>18</sup>F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma
Supplemental data

PLATELETS AND THROMBOPOIESIS

Clonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study
Bruno Fattizzo,Alfredo Marchetti,Alessandro Bosi,Carmelo Gurnari,Juri Alessandro Giannotta,Giacinto Luca Pedone,Elena Rossi,Valentina Carrai,Andrea Guido,Filippo Brioschi,Monica Carpenedo,Monica Crugnola,Domenica Caramazza,Livia Leuzzi,Monia Marchetti,Gabriele Merati,Simona Malato,Fabrizio Vianello,Andrea Patriarca,Hussein Awada,Marta Bortolotti,Marta Canzi,Niccolò Bolli,Marco Capecchi,Frederick Chen,Andrea Artoni,Jaroslaw P. Maciejewski,Wilma Barcellini
View Articletitled, Clonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study
Supplemental data

THROMBOSIS AND HEMOSTASIS

Loss of protein C vs protein S results in discrepant thrombotic phenotypes
Chia-Jui Ku,Xinge Yu,Queena Y. Zhao,Steven J. Grzegorski,Jeffrey G. Daniel,Allison C. Ferguson,Jordan A. Shavit
View Articletitled, Loss of protein C vs protein S results in discrepant thrombotic phenotypes
Supplemental data

TRANSPLANTATION

Measurable residual disease as predictor of post–day +100 relapses after allografting in adult AML
Clinical Trials & Observations
Naveed Ali,Megan Othus,Eduardo Rodríguez-Arbolí,Corentin Orvain,Filippo Milano,Brenda M. Sandmaier,Chris Davis,Ryan S. Basom,Frederick R. Appelbaum,Roland B. Walter
View Articletitled, Measurable residual disease as predictor of post–day +100 relapses after allografting in adult AML
PTCy-based graft-versus-host disease prophylaxis for matched sibling donor allogeneic hematopoietic cell transplantation
Nihar Desai,Majed Altareb,Mats Remberger,Carol Chen,Tommy Alfaro Moya,Eshrak Al-Shaibani,Igor Novitzky-Basso,Ivan Pasic,Wilson Lam,Fotios V. Michelis,Armin Gerbitz,Auro Viswabandya,Rajat Kumar,Dennis Dong Hwan Kim,Jeffrey H. Lipton,Jonas Mattsson,Arjun Datt Law
View Articletitled, PTCy-based graft-versus-host disease prophylaxis for matched sibling donor allogeneic hematopoietic cell transplantation
Supplemental data
PTCy unchained in matched siblings: the D is silent in GVHD
Nico Gagelmann,Anant Vatsayan
View Articletitled, PTCy unchained in matched siblings: the D is silent in GVHD

RESEARCH LETTERS

Recurrent ETV3::NCOA2 fusions and MAPK pathway mutations in indeterminate dendritic cell histiocytosis
Clinical Trials & Observations
Paul G. Kemps,F. J. Sherida H. Woei-A-Jin,Koen D. Quint,Cor van den Bos,Leonie Naeije,Jan A. M. van Laar,Isabelle Vanden Bempt,Marco J. Koudijs,Ruben H. P. Vorderman,Ellen Stelloo,Joost F. Swennenhuis,Annette H. Bruggink,Konnie M. Hebeda,Marijn A. Scheijde-Vermeulen,Gilles F. H. Diercks,Robert M. Verdijk,Patty M. Jansen,Esther Hauben,Thomas Tousseyn,Arjen H. G. Cleven,Tom van Wezel,Astrid G. S. van Halteren,Pancras C. W. Hogendoorn
View Articletitled, Recurrent <em>ETV3</em>::<em>NCOA2</em> fusions and MAPK pathway mutations in indeterminate dendritic cell histiocytosis
Supplemental data
IDCH: is it now determined?
Clinical Trials & Observations
Nitya Gulati,Jennifer Picarsic
View Articletitled, IDCH: is it now determined?
A telemedicine triage model for infusion center–based management of adult sickle cell pain episodes
John Bliamptis,Alan You,Jessica Groesbeck,Stefanie Sacknoff,Sinead Byrne,Srila Gopal
View Articletitled, A telemedicine triage model for infusion center–based management of adult sickle cell pain episodes
Supplemental data

RESPONSE

Racial and socioeconomic status diversity and GVHD outcomes
Nosha Farhadfar,Stephanie J. Lee
View Articletitled, Racial and socioeconomic status diversity and GVHD outcomes
  • Cover Image

    Cover Image

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    Diaminofluorescein-FM diacetate staining reveals nitric oxide accumulation after injury to a zebrafish larval tail, a phenotype absent in proc-/- (protein C) mutants. See the article by Ku et al.

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