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Issue Archive

Volume 9, Issue 10
May 27 2025
Blood Advances Cover Image for Volume 9, Issue 10

Table of Contents

INSIDE BLOOD ADVANCES

Breaking the cycle: PRMTs and secondary HLH relief
Sakshi Malik,Shanmuganathan Chandrakasan
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Weighing the evidence on GLP1s and venous thromboembolism
Damon E. Houghton,Karlyn A. Martin
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Tocilizumab prophylaxis in double cord blood transplantation
William R. Drobyski
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CLINICAL GUIDELINES

American Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients
Paul Monagle,Muayad Azzam,Rachel Bercovitz,Marisol Betensky,Rukhmi Bhat,Tina Biss,Brian Branchford,Leonardo R. Brandão,Anthony K. C. Chan,E. Vincent S. Faustino,Julie Jaffray,Sophie Jones,Hassan Kawtharany,Bryce A. Kerlin,Nicole Kucine,Riten Kumar,Christoph Male,Marie-Claude Pelland-Marcotte,Leslie Raffini,Chittalsinh Raulji,Sarah E. Sartain,Clifford M. Takemoto,Cristina Tarango,C. Heleen van Ommen,Maria C. Velez,Sara K. Vesely,John Wiernikowski,Suzan Williams,Hope P. Wilson,Gary Woods,Ayesha Zia,Reem A. Mustafa
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CLINICAL TRIALS AND OBSERVATIONS

Mosunetuzumab plus Pola-CHP compared with Pola-R-CHP in previously untreated DLBCL: final results from a phase 2 study
Clinical Trials & Observations
Jason Westin,Tycel J. Phillips,Amitkumar Mehta,Marc S. Hoffmann,Eva Gonzalez-Barca,Catherine Thieblemont,Mariana Bastos-Oreiro,Richard Greil,Sebastian Giebel,Michael C. Wei,Jue Wang,Reinhard Bucher,Jason Sit,Elicia Penuel,Enkhtsetseg Purev,Donald L. Yee,Juan Miguel Bergua-Burgues
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Characterization and treatment outcomes of malignant histiocytoses in a retrospective series of 141 cases in France
Clinical Trials & Observations
Camille Bigenwald,Damien Roos-Weil,Arnaud Pagès,Zofia Hélias-Rodzewicz,Christiane Copie-Bergman,Marzieh Nashvi,Pierre Khneisser,Marie Parrens,Alexandra Traverse-Glehen,Isabelle Ray-Coquard,Loïc Ysebaert,Tony Marchand,Jérôme Razanamahery,Frédéric Charlotte,Antoine Neel,Gandhi Damaj,Jérémie Dion,Eve-Marie Nazal-Traissac,Stéphanie Tardy,Géraldine Salmeron,Hélène Monjanel,Ahmed Idbaih,Sébastien Héritier,Julien Haroche,Jean Donadieu,Jean-François Emile
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Safety run-in and part 1 of GIMEMA AML1718: venetoclax combined with FLAI as induction treatment in non–low-risk AML
Clinical Trials & Observations
Giovanni Marconi,Alfonso Piciocchi,Ernesta Audisio,Cristina Papayannidis,Marco Cerrano,Clara Minotti,Francesca Paoloni,Fabio Guolo,Monica Bocchia,Michela Rondoni,Albana Lico,Matteo G. Carrabba,Matteo Giovanni Della Porta,Marco Frigeni,Luisa Giaccone,Germana Beltrami,Chiara Cattaneo,Maria Chiara Di Chio,Bianca Serio,Enrico Crea,Roberto Freilone,Saveria Capria,Antonio Curti,Paola Minetto,Edoardo la Sala,Jacopo Nanni,Beatrice Anna Zannetti,Giorgia Simonetti,Maria Teresa Bochicchio,Giuseppe Saglio,Roberto M. Lemoli,Adriano Venditti,Marco Vignetti,Paola Fazi,Giovanni Martinelli
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Supplemental data
Intermediate-dose posttransplantation cyclophosphamide for myeloablative HLA-haploidentical bone marrow transplantation
Clinical Trials & Observations
Mustafa A. Hyder,Dimana Dimitrova,Ruby Sabina,Ashley DeVries,Jeannine S. McCune,Meredith J. McAdams,Francis A. Flomerfelt,Christi McKeown,Jennifer L. Sadler,Amy Chai,Thomas E. Hughes,Scott Napier,Anita Stokes,Jennifer Sponaugle,Kamil Rechache,Mark Parta,Jennifer Cuellar-Rodriguez,William D. Figg,Hyoyoung Choo-Wosoba,Seth M. Steinberg,Jennifer A. Kanakry,Christopher G. Kanakry
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GENE THERAPY

Protection of CD33-modified hematopoietic stem cell progeny from CD33-directed CAR T cells in rhesus macaques
Nicholas E. Petty,Stefan Radtke,Greta Kanestrom,Emily Fields,Olivier Humbert,Salvatore Fiorenza,Mallory J. Llewellyn,George S. Laszlo,Justin Thomas,Zach Burger,Kyle Swing,Haiying Zhu,Keith R. Jerome,Cameron J. Turtle,Roland B. Walter,Hans-Peter Kiem
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis
Fiona Brown-Burke,Rachel Saadey,Hsiao-Yin Charlene Mao,Paola Marra,Eric Brooks,Alexa Wandtke,Ian Hout,Sydney Leon,Archisha Sharma,Aneeq Yasin,Taylor Cash,Elshafa Hassan Ahmed,Ethan Baiocchi,Stephanie Finoti,Xiaoli Zhang,Neha Bhagwat,Kris Vaddi,Peggy Scherle,Anna Mozhenkova,Ikbale El-Ayachi,Austin D. Schenk,Shelby L. Sloan,Kaylee Whitman,JoBeth Helmig-Mason,Sheldon Steyn,Haley L. Klimaszewski,Jessica Weist,Christoph Weigel,Shirsha Koirala,Lapo Alinari,Katiri Snyder,Parvathi Ranganathan,Chia-Jo Chen,Michael B. Jordan,Robert A. Baiocchi,Polina Shindiapina
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Breaking the cycle: PRMTs and secondary HLH relief
Sakshi Malik,Shanmuganathan Chandrakasan
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Created in BioRender. Gamal, W. (2025) https://BioRender.com/f82z772

Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model
Wael Gamal,Nienke B. Goedhart,Helga Simon-Molas,Melanie Mediavilla-Varela,Angimar Uriepero-Palma,Fleur S. Peters,Kamira Maharaj,Julio C. Chavez,John Powers,Alyssa Obermayer,Timothy I. Shaw,José R. Conejo-Garcia,Paulo C. Rodriguez,Eva Sahakian,Javier Pinilla-Ibarz,Arnon P. Kater
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LYMPHOID NEOPLASIA

Rituximab for children with EBV-positive Burkitt lymphoma in East Africa
Global Advances
William Frank Mawalla,Caroline Achola,Hadijah Nabalende,Isaac Otim,Ismail D. Legason,Martin D. Ogwang,Pamella M. Aol,Godlove Sandi,Hadija Mwamtemi,Salama Mahawi,Elifuraha Mkwizu,Philomena G. Lyamuya,Jacqueline P. Kamanga,Kristin Schroeder,Paul Ntemi,Clara Chamba,Dimitris Vavoulis,Liz Morrell,Lulu Chirande,Anna Schuh
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Subgroup analysis of older patients ≥60 years with diffuse large B-cell lymphoma in the phase 3 POLARIX study
Clinical Trials & Observations
Bei Hu,Patrick M. Reagan,Laurie H. Sehn,Jeff P. Sharman,Mark Hertzberg,Huilai Zhang,Austin Kim,Charles Herbaux,Lysiane Molina,Dai Maruyama,Frank Stenner,Saibah Chohan,Rucha Kothari,Connie Lee Batlevi,Jamie Hirata,Deniz Sahin,Calvin Lee,Matthew Sugidono,Hervé Tilly
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Outcome of high-grade B-cell lymphoma compared with other large B-cell lymphoma after CAR-T rescue: a DESCAR-T LYSA study
Xavier Phina-Ziebin,Emmanuel Bachy,François-Xavier Gros,Roberta Di Blasi,Charles Herbaux,Jacques Olivier Bay,Sylvain Carras,Pierre Bories,Olivier Casasnovas,Fabrice Jardin,Franck Morschhauser,Blandine Guffroy,Mohamad Mohty,Elodie Gat,Julien Calvani,Marie-Cécile Parrens,Elsa Poullot,Alexandra Traverse-Glehen,Louise Roulin
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RED CELLS, IRON, AND ERYTHROPOIESIS

Identification of 2 novel noncoding variants in patients with Diamond-Blackfan anemia syndrome by whole genome sequencing
Ting Wen,Steven E. Boyden,Caleb M. Hocutt,Robert G. Lewis,Erin E. Baldwin,Jennie Vagher,Ashley Andrews,Thomas J. Nicholas,Alexander Chapin,Elaine M. Fan,Lorenzo D. Botto,Pinar Bayrak-Toydemir,Rong Mao,Jessica A. Meznarich
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THROMBOSIS AND HEMOSTASIS

The preclinical profile of SerpinPC: a potential new treatment for hemophilia
James A. Huntington,Jill Reckless,Stéphanie G. I. Polderdijk,Patrick Hextall,Trevor P. Baglin
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Glucagon-like peptide 1 receptor agonists and venous thromboembolism in type 2 diabetes: a target trial emulation
Cho-Han Chiang,Junmin Song,Yu-Cheng Chang,Soravis Osataphan,Yu-Che Lee,Ko-Yun Chang,Kuan-Yu Chi,Cho-Hung Chiang,Anahita Dua,Leslie Lake,Mandy N. Lauw,Kenneth A. Bauer,Dhruv S. Kazi,Rushad Patell
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Weighing the evidence on GLP1s and venous thromboembolism
Damon E. Houghton,Karlyn A. Martin
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TRANSPLANTATION

Phase 2 trial of cyclosporine-A, mycophenolate mofetil, and tocilizumab GVHD prophylaxis in cord blood transplantation
Clinical Trials & Observations
Ioannis Politikos,Samantha Brown,Joshua A. Fein,Stephen Eng,Kristian Casem,Stephanie Chinapen,Sean Quach,Andromachi Scaradavou,Christina Cho,Parastoo Dahi,Sergio A. Giralt,Boglarka Gyurkocza,Alan M. Hanash,Ann A. Jakubowski,Esperanza B. Papadopoulos,Miguel-Angel Perales,Doris M. Ponce,Brian C. Shaffer,Roni Tamari,James W. Young,Sean Devlin,Jonathan U. Peled,Juliet N. Barker
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Tocilizumab prophylaxis in double cord blood transplantation
William R. Drobyski
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VASCULAR BIOLOGY

Nilotinib attenuates vascular pathology in experimental cerebral malaria
Luana S. Ortolan,Priyanka Bansal,Veronica I. Primavera,Rodrigo J. R. X. Freitas,Ling Wei,Sabrina Epiphanio,Alexis Kaushansky,Joseph D. Smith
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RESEARCH LETTERS

ATM inhibition decreases ERK activation and is synergistic with ibrutinib in primary chronic lymphocytic leukemia cells
Sara E. F. Kost,Ali Saleh,Jennifer Brown,Shek H. Yuan,Bozena Kuzio,Lin Yang,Versha Banerji,Spencer B. Gibson,James B. Johnston,Sachin Katyal
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Cytogenetic annotation automation in myelodysplastic syndrome research databases
Samuel Urrutia,Kelly S. Chien,Ziyi Li,Alexandre Bazinet,Guilin Tang,Guillermo Garcia-Manero
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Long-term outcomes of chemoimmunotherapy with obinutuzumab/chlorambucil in chronic lymphocytic leukemia
Clinical Trials & Observations
Valentin Goede,Kirsten Fischer,Sandra Robrecht,Adam Giza,Martin J. S. Dyer,Michael J. Eckart,Lothar Mϋller,Lukáš Smolej,Nadine Kutsch,Anna-Maria Fink,Stephan Stilgenbauer,Michael Hallek
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Immune-aging is linked to clinical malignancy, racial ancestry, and vaccine responses in myeloma
Sayalee V. Potdar,Shivani Kapadia,Maryam I. Azeem,Roman Radzievski,Kiran Lakhani,Nisha S. Joseph,Jonathan L. Kaufman,Craig C. Hofmeister,Vikas A. Gupta,Sagar Lonial,Ajay K. Nooka,Kavita M. Dhodapkar,Madhav V. Dhodapkar
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Assessing AML-based risk criteria in patients with accelerated/blast-phase MPN treated with less-intensive therapy
Reid Shaw,James J. Yoon,Hannah Johnston,Marta B. Davidson,Alexa J. Siddon,Rory M. Shallis,Evan C. Chen,Madelyn Burkart,Timothy S. Oh,Sunil G. Iyer,Ellen Madarang,Chandrasekar Muthiah,Joshua Kassner,Raajit K. Rampal,Guru Subramanian Guru Murthy,Terrence Bradley,Yasmin Abaza,Jacqueline S. Garcia,Vikas Gupta,Kristen M. Pettit,Olatoyosi Odenike,Anand A. Patel
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COMMENTARY

What to do with the weight while preparing for CAR-T?
Samuel J. Yates,Ishan Roy
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ERRATA

John TD, Walters MC, Rangarajan HG, et al. Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease. Blood Adv. 2024;8(23):6055-6063.
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Kuaban A, Croker AK, Keefer J, et al. The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative. Blood Adv. 2025;9(4):687-695.
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  • Cover Image

    Cover Image

    issue cover

    Brain section of a Plasmodium berghei ANKA–infected mouse shows hemorrhages (hematoxylin and eosin stain; image magnified 20×). Brain hemorrhages are decreased in infected mice treated with nilotinib. See the article by Ortolan et al.

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