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Nigel S. Key
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Journal Articles

Plasma kallikrein supports FXII-independent thrombin generation in mouse whole blood

Jun Wan, Sophia Dhrolia, Rohan R. Kasthuri, Yuriy Prokopenko, Anton Ilich, Prakash Saha, Mark Roest, Alisa S. Wolberg, Nigel S. Key, Rafal Pawlinski, Pavan K. Bendapudi, Nigel Mackman, Steven P. Grover
Journal: Blood Advances
Blood Adv (2024) 8 (12): 3045–3057.
https://doi.org/10.1182/bloodadvances.2024012613
Published: 2024
Includes: Supplemental data
Journal Articles

Stable and durable factor IX levels in patients with hemophilia B over 3 years after etranacogene dezaparvovec gene therapy

Clinical Trials & Observations
Annette von Drygalski, Esteban Gomez, Adam Giermasz, Giancarlo Castaman, Nigel S. Key, Susan U. Lattimore, Frank W. G. Leebeek, Wolfgang A. Miesbach, Michael Recht, Robert Gut, Ricardo Dolmetsch, Paul E. Monahan, Sandra Le Quellec, Steven W. Pipe
Journal: Blood Advances
Blood Adv (2023) 7 (19): 5671–5679.
https://doi.org/10.1182/bloodadvances.2022008886
Published: 2023
Includes: Supplemental data
Journal Articles

Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia

Clinical Trials & Observations
Anton Ilich, Terry B. Gernsheimer, Darrell J. Triulzi, Heather Herren, Siobhan P. Brown, Lori A. Holle, Andrew T. Lucas, Bas de Laat, Nahed El Kassar, Alisa S. Wolberg, Susanne May, Nigel S. Key
Journal: Blood Advances
Blood Adv (2023) 7 (6): 900–908.
https://doi.org/10.1182/bloodadvances.2022008255
Published: 2023
Includes: Supplemental data
Journal Articles

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

Michael W. Henderson, Franciele Lima, Carla Roberta Peachazepi Moraes, Anton Ilich, Stephany Cares Huber, Mayck Silva Barbosa, Irene Santos, Andre C. Palma, Thyago Alves Nunes, Raisa Gusso Ulaf, Luciana Costa Ribeiro, Ana Flavia Bernardes, Bruna Bombassaro, Sergio San Juan Dertkigil, Maria Luiza Moretti, Sidney Strickland, Joyce M. Annichino-Bizzacchi, Fernanda Andrade Orsi, Eli Mansour, Licio A. Velloso, Nigel S. Key, Erich Vinicius De Paula
Journal: Blood Advances
Blood Adv (2022) 6 (11): 3367–3377.
https://doi.org/10.1182/bloodadvances.2021006620
Published: 2022
Includes: Supplemental data
Journal Articles

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles

Nadim Tawil, Rayhaan Bassawon, Brian Meehan, Ali Nehme, Laura Montermini, Tenzin Gayden, Nicolas De Jay, Cristiana Spinelli, Shilpa Chennakrishnaiah, Dongsic Choi, Lata Adnani, Michele Zeinieh, Nada Jabado, Claudia L. Kleinman, Michael Witcher, Yasser Riazalhosseini, Nigel S. Key, David Schiff, Steven P. Grover, Nigel Mackman, Charles P. Couturier, Kevin Petrecca, Mario L. Suvà, Anoop Patel, Itay Tirosh, Hamed Najafabadi, Janusz Rak
Journal: Blood Advances
Blood Adv (2021) 5 (6): 1682–1694.
https://doi.org/10.1182/bloodadvances.2020002998
Published: 2021
Includes: Supplemental data
Journal Articles

Recombinant porcine FVIII for bleed treatment in acquired hemophilia A: findings from a single-center, 18-patient cohort

Clinical Trials & Observations
Patrick Ellsworth, Sheh-Li Chen, Raj S. Kasthuri, Nigel S. Key, Micah J. Mooberry, Alice D. Ma
Journal: Blood Advances
Blood Adv (2020) 4 (24): 6240–6249.
https://doi.org/10.1182/bloodadvances.2020002977
Published: 2020
Journal Articles

Inhibitors and mortality in persons with nonsevere hemophilia A in the United States

Clinical Trials & Observations
Ming Y. Lim, Dunlei Cheng, Michael Recht, Christine L. Kempton, Nigel S. Key
Journal: Blood Advances
Blood Adv (2020) 4 (19): 4739–4747.
https://doi.org/10.1182/bloodadvances.2020002626
Published: 2020
Includes: Supplemental data
Journal Articles

Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease

Erdem Kucukal, Yuncheng Man, Erina Quinn, Neil Tewari, Ran An, Anton Ilich, Nigel S. Key, Jane A. Little, Umut A. Gurkan
Journal: Blood Advances
Blood Adv (2020) 4 (15): 3688–3698.
https://doi.org/10.1182/bloodadvances.2020001656
Published: 2020
Includes: Supplemental data
Journal Articles

Etranacogene dezaparvovec (AMT-061 phase 2b): normal/near normal FIX activity and bleed cessation in hemophilia B

Annette Von Drygalski, Adam Giermasz, Giancarlo Castaman, Nigel S. Key, Susan Lattimore, Frank W. G. Leebeek, Wolfgang Miesbach, Michael Recht, Alison Long, Robert Gut, Eileen K. Sawyer, Steven W. Pipe
Journal: Blood Advances
Blood Adv (2019) 3 (21): 3241–3247.
https://doi.org/10.1182/bloodadvances.2019000811
Published: 2019
Includes: Supplemental data
Journal Articles

Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products

Wojciech Jankowski, Yara Park, Joseph McGill, Eugene Maraskovsky, Marco Hofmann, Vincent P. Diego, Bernadette W. Luu, Tom E. Howard, Roberta Kellerman, Nigel S. Key, Zuben E. Sauna
Journal: Blood Advances
Blood Adv (2019) 3 (9): 1429–1440.
https://doi.org/10.1182/bloodadvances.2018030452
Published: 2019
Includes: Supplemental data
Journal Articles

Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children

Global Advances
Patrick T. McGann, Anne M. Williams, Graham Ellis, Kathryn E. McElhinney, Laurel Romano, Julia Woodall, Thad A. Howard, Gerald Tegha, Robert Krysiak, R. Murray Lark, E. Louise Ander, Carine Mapango, Kenneth I. Ataga, Satish Gopal, Nigel S. Key, Russell E. Ware, Parminder S. Suchdev
Journal: Blood Advances
Blood Adv (2018) 2 (21): 3035–3044.
https://doi.org/10.1182/bloodadvances.2018023069
Published: 2018
Journal Articles

A cross-sectional analysis of cardiovascular disease in the hemophilia population

Clinical Trials & Observations
Suman L. Sood, Dunlei Cheng, Margaret Ragni, Craig M. Kessler, Doris Quon, Amy D. Shapiro, Nigel S. Key, Marilyn J. Manco-Johnson, Adam Cuker, Christine Kempton, Tzu-Fei Wang, M. Elaine Eyster, Philip Kuriakose, Annette von Drygalski, Joan Cox Gill, Allison Wheeler, Peter Kouides, Miguel A. Escobar, Cindy Leissinger, Sarah Galdzicka, Marshall Corson, Crystal Watson, Barbara A. Konkle
Journal: Blood Advances
Blood Adv (2018) 2 (11): 1325–1333.
https://doi.org/10.1182/bloodadvances.2018018226
Published: 2018