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Journal Articles

Unbiased High-Throughput Screening of Drug-Repurposing Libraries Identifies Small-Molecule Inhibitors of Clot Retraction

Lorena Buitrago, Miriam-Rose Menezes, Chloe Larson, Jihong Li, Thomas Kartika, Priyam Banerjee, Fraser Glickman, Barry S. Coller

Blood Adv bloodadvances.2024013810.

https://doi.org/10.1182/bloodadvances.2024013810

Published: 2024

Includes: Supplemental data

Journal Articles

An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding

Lu Wang, Jialing Wang, Jihong Li, Thomas Walz, Barry S. Coller

Blood Adv (2024) 8 (16): 4398–4409.

https://doi.org/10.1182/bloodadvances.2024013177

Published: 2024

Includes: Supplemental data

Journal Articles

Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding

Dragana Nešić, Martin Bush, Aleksandar Spasic, Jihong Li, Tetsuji Kamata, Makoto Handa, Marta Filizola, Thomas Walz, Barry S. Coller

Blood Adv (2021) 5 (7): 1781–1790.

https://doi.org/10.1182/bloodadvances.2020004166

Published: 2021

Includes: Supplemental data

Journal Articles

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer

Lorena Buitrago, Hina Zafar, Yixiao Zhang, Jihong Li, Thomas Walz, Barry S. Coller

Blood Adv (2020) 4 (13): 2939–2949.

https://doi.org/10.1182/bloodadvances.2020001545

Published: 2020

Journal Articles

αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible

Hina Zafar, Yi Shang, Jihong Li, George A. David, III, Joseph P. Fernandez, Henrik Molina, Marta Filizola, Barry S. Coller

Blood Adv (2017) 1 (7): 417–428.

https://doi.org/10.1182/bloodadvances.2017004689

Published: 2017

Includes: Supplemental data

NARROW

Unbiased High-Throughput Screening of Drug-Repurposing Libraries Identifies Small-Molecule Inhibitors of Clot Retraction

An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding

Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer

αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible

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ASH Publications

American Society of Hematology

Unbiased High-Throughput Screening of Drug-Repurposing Libraries Identifies Small-Molecule Inhibitors of Clot Retraction

An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding

Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer

αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible

Email alerts

ASH Publications

American Society of Hematology

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