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Jean-François Spinella
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Journal Articles

Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML

Julien M. P. Grenier, Céline Testut, Matthieu Bal, Florence Bardin, Maria De Grandis, Véronique Gelsi-Boyer, Julien Vernerey, Marjorie Delahaye, Samuel Granjeaud, Christophe Zemmour, Jean-François Spinella, Triantafyllos Chavakis, Stéphane J. C. Mancini, Jean-Marie Boher, Josée Hébert, Guy Sauvageau, Norbert Vey, Jürg Schwaller, Marie-Anne Hospital, Cyril Fauriat, Michel Aurrand-Lions
Journal: Blood Advances
Blood Adv (2024) 8 (17): 4662–4678.
https://doi.org/10.1182/bloodadvances.2023011747
Published: 2024
Includes: Supplemental data
Journal Articles

HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition

Céline Moison, Jean-François Spinella, Jalila Chagraoui, Vincent-Philippe Lavallée, Bernhard Lehnertz, Clarisse Thiollier, Isabel Boivin, Nadine Mayotte, Tara MacRae, Anne Marinier, Josée Hébert, Guy Sauvageau
Journal: Blood Advances
Blood Adv (2022) 6 (16): 4793–4806.
https://doi.org/10.1182/bloodadvances.2021005828
Published: 2022
Includes: Supplemental data
Journal Articles

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

Sophie Cardin, Mélanie Bilodeau, Mathieu Roussy, Léo Aubert, Thomas Milan, Loubna Jouan, Alexandre Rouette, Louise Laramée, Patrick Gendron, Jean Duchaine, Hélène Decaluwe, Jean-François Spinella, Stéphanie Mourad, Françoise Couture, Daniel Sinnett, Élie Haddad, Josette-Renée Landry, Jing Ma, R. Keith Humphries, Philippe P. Roux, Josée Hébert, Tanja A. Gruber, Brian T. Wilhelm, Sonia Cellot
Journal: Blood Advances
Blood Adv (2019) 3 (21): 3307–3321.
https://doi.org/10.1182/bloodadvances.2019030981
Published: 2019
Includes: Supplemental data
Journal Articles

Mutational dynamics of early and late relapsed childhood ALL: rapid clonal expansion and long-term dormancy

Clinical Trials & Observations
Jean-François Spinella, Chantal Richer, Pauline Cassart, Manon Ouimet, Jasmine Healy, Daniel Sinnett
Journal: Blood Advances
Blood Adv (2018) 2 (3): 177–188.
https://doi.org/10.1182/bloodadvances.2017011510
Published: 2018
Includes: Supplemental data