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Journal Articles

Pivotal results of SELECT-MDS-1 phase 3 study of tamibarotene with azacitidine in newly diagnosed higher-risk MDS

Open Access
Clinical Trials & Observations
Amy E. DeZern, Sylvain Thepot, Stephane de Botton, Andrea Patriarca, Dries Deeren, Jose-Miguel Torregrossa-Diaz, Giovanni Marconi, Teresa Bernal, Juan Bergua Burgues, Blanca Xicoy, Anna Jonášová, Amer M. Zeidan, Sophie Dimicoli-Salazar, Célestine Simand, David Valcarcel, Maria Diez Campelo, Wanxing Chai-Ho, Lalit Saini, Alice Garnier, Klaus Geissler, Yishai Ofran, Zsolt Nagy, Pramila Krishnamurthy, Michael Lübbert, Grzegorz Basak, Hetty E. Carraway, David A. Sallman, Uma Borate, Valeria Santini, Victoria Campbell, Pierre Fenaux, Thorsten Braun, Francesco Lanza, Jan Maciej Zaucha, David A. Roth, Sofia Paul, Pourab Roy, Michael J. Kelly, Angela Volkert, Jaime Chisholm, Tanya Abdul Malak, Virginia M. Klimek, Thomas Cluzeau
Journal: Blood Advances
Blood Adv (2025) 9 (16): 4090–4099.
https://doi.org/10.1182/bloodadvances.2025016229
Published: 2025
Includes: Supplemental data
Journal Articles

IGSF9-targeted therapy inhibits the progression of acute myeloid leukemia

Open Access
Lijun Hui, Jing Xiao, Zhiling Zhao, Juan Zhang, Huiwen Luan, Jiashen Zhang, Yuxiao Sun, Xianhui Meng, Hongying Wang, Chunling Li, Fangmin Li, Shuhao Ji, Shuping Wei, Fang Li, Hong Yu, Chengyun Zheng, Yang Jiang, Yaopeng Wang, Zunling Li
Journal: Blood Advances
Blood Adv (2025) 9 (16): 4217–4231.
https://doi.org/10.1182/bloodadvances.2025016432
Published: 2025
Includes: Supplemental data
Journal Articles

RBC transfusion dependency refines the Molecular International Prognostic Scoring System for myelodysplastic syndrome

Open Access
Thomas Wiseman, Michaela Spooner, Shreyas Khanna, Kevin Hung, Carla R. Toop, Monika Kutyna, Joanne Yu, Anna Brown, Hamish Scott, Christopher Hahn, Chung Hoow Kok, Devendra Hiwase
Journal: Blood Advances
Blood Adv (2025) 9 (16): 4244–4247.
https://doi.org/10.1182/bloodadvances.2025016086
Published: 2025
Includes: Supplemental data
Journal Articles

Genome-wide association study of somatic GATA1s mutations in newborns with Down syndrome

Open Access
Yunqi Li, Natalina Elliott, Patricia Lein, Paresh Vyas, Irene Roberts, Adam J. de Smith
Journal: Blood Advances
Blood Adv (2025) 9 (16): 4235–4243.
https://doi.org/10.1182/bloodadvances.2025016282
Published: 2025
Includes: Supplemental data
Journal Articles

Asciminib remained superior vs bosutinib in late-line CML-CP after nearly 4 years of follow-up in ASCEMBL

Open Access
Clinical Trials & Observations
Michael J. Mauro, Yosuke Minami, Andreas Hochhaus, Elza Lomaia, Sergey Voloshin, Anna Turkina, Dong-Wook Kim, Jane F. Apperley, Jorge E. Cortes, Andre Abdo, Laura Maria Fogliatto, Dennis Dong Hwan Kim, Philipp le Coutre, Susanne Saussele, Mario Annunziata, Timothy P. Hughes, Naeem Chaudhri, Lynette Chee, Valentin García-Gutiérrez, Koji Sasaki, Carla Boquimpani, Shruti Kapoor, Noemi Espurz, Vishal Dhamal, Delphine Rea
Journal: Blood Advances
Blood Adv (2025) 9 (16): 4248–4259.
https://doi.org/10.1182/bloodadvances.2025016042
Published: 2025
Includes: Supplemental data
Journal Articles

Vaccine-Educated T cells and a CD123 Bispecific T-Cell Engager for Treatment of Acute Myeloid Leukemia

Open Access
Jessica Liegel, Dina Stroopinsky, Giulia Cheloni, Dimitra Karagkouni, Myrna Nahas, Yuling Ma, Daniela Torres, Isabella Saldarriaga, Shuoshuo Wang, Antonella Arruda de Amaral, Athanasios Ploumakis, Sean G Clohessy, Joseph Abirached, Lina Bisharat, Paula G. Fraenkel, Ozlem Yildirim, Hélène Bonnevaux, Stephane Guerif, Katie Rallis, Georges Chedid, Donald Kufe, Ioannis S Vlachos, David E. Avigan, Jacalyn Rosenblatt
Journal: Blood Advances
Blood Adv bloodadvances.2024015449.
https://doi.org/10.1182/bloodadvances.2024015449
Published: 2025
Includes: Supplemental data
Journal Articles

Overcoming venetoclax resistance through heme-mediated NOXA/cyclin D1/Mcl-1 axis with a novel artemisinin conjugate

Open Access
Jingyi Zhang, Zhenwei Zhang, Jinghua Liu, Shenglin Luan, Jiqiang Qu, Zi Wu, Yafei Kuang, Ping Gong, Yu Bao, Yuetong Wang, Xiaojing Yan, Samuel Waxman, Linxiang Zhao, Yongkui Jing
Journal: Blood Advances
Blood Adv bloodadvances.2025015806.
https://doi.org/10.1182/bloodadvances.2025015806
Published: 2025
Includes: Supplemental data
Journal Articles

Targeting PD-1 for HCT relapse: an immunologic knife’s edge

Open Access
Clinical Trials & Observations
Roman M. Shapiro, Robert J. Soiffer
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3907–3908.
https://doi.org/10.1182/bloodadvances.2025016709
Published: 2025
Journal Articles

Frontline allo-SCT in MRD-negative, intermediate-risk AML

Open Access
Eduardo Rodríguez-Arbolí, Teresa Caballero-Velázquez, Cristina Marrero-Cepeda, José Antonio Pérez-Simón
Journal: Blood Advances
Blood Adv (2025) 9 (15): 4063–4064.
https://doi.org/10.1182/bloodadvances.2025016610
Published: 2025
Journal Articles

Integrating MRD kinetics with allogeneic SCT decisions in AML

Open Access
Wei-Ying Jen, Nicholas J. Short
Journal: Blood Advances
Blood Adv (2025) 9 (15): 4065–4066.
https://doi.org/10.1182/bloodadvances.2025016766
Published: 2025
Journal Articles

Outcomes of haploidentical vs mismatched unrelated donor HCT with posttransplant cyclophosphamide prophylaxis

Open Access
Yosra M. Aljawai, Jeremy Ramdial, Gabriela Rondon, Portia Smallbone, Partow Kebriaei, Uday Popat, Betul Oran, Katayoun Rezvani, Richard E. Champlin, Elizabeth J. Shpall, Rohtesh S. Mehta
Journal: Blood Advances
Blood Adv (2025) 9 (15): 4023–4036.
https://doi.org/10.1182/bloodadvances.2025016236
Published: 2025
Includes: Supplemental data
Journal Articles

Ethical Considerations for Hematologic Precursor Conditions

Open Access
Eric C. Blackstone, Lachelle D. Weeks, Amy E. DeZern, Gregory A. Abel
Journal: Blood Advances
Blood Adv bloodadvances.2025017215.
https://doi.org/10.1182/bloodadvances.2025017215
Published: 2025
Includes: Supplemental data
Journal Articles

Clec12a is required for the pathogenesis of NUP98::NSD1 AML

Open Access
Sagarajit Mohanty, Fiorella Charles Cano, Razif Gabdoulline, Courteney K. Lai, Basem Othman, Harish Sudarsanam, Thomas Eder, Florian Grebien, Daniel B. Lipka, Reinhard Henschler, Michael Heuser
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3887–3899.
https://doi.org/10.1182/bloodadvances.2024015739
Published: 2025
Includes: Supplemental data
Journal Articles

PD-1 inhibition for relapse after allogeneic transplantation in acute myeloid leukemia and myelodysplastic syndrome

Open Access
Clinical Trials & Observations
John M. Magenau, David G. Frame, Mary Riwes, John Maciejewski, Sarah Anand, Attaphol Pawarode, Anamarija M. Perry, Marcus Geer, Thomas Braun, Monalisa Ghosh, Pavan Reddy
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3878–3886.
https://doi.org/10.1182/bloodadvances.2024015200
Published: 2025
Includes: Supplemental data
Journal Articles

Cost-Effectiveness of Upfront vs. Delayed Allogeneic Hematopoietic Stem Cell Transplant for Intermediate Risk AML

Open Access
Abdulrahman Alhajahjeh, Kishan Patel, Nikolai A. Podoltsev, Tariq Kewan, Jessica M. Stempel, Lourdes M Mendez, Stuart E Seropian, Lohith Gowda, Scott F. Huntington, Maximilian F. Stahl, Amer M Zeidan, George Goshua, Jan P. Bewersdorf
Journal: Blood Advances
Blood Adv bloodadvances.2025016532.
https://doi.org/10.1182/bloodadvances.2025016532
Published: 2025
Includes: Supplemental data
Journal Articles

Somatic Mutations in STAG2 Are Associated with Separated Megakaryocyte Nuclear Lobes in Myelodysplastic Syndromes

Open Access
Waihay J Wong, Rebecca L Zon, Christopher J. Gibson, Caleb Ho, Olga Pozdnyakova, Donna S. Neuberg, Elisabeth M. Battinelli, Marlise R. Luskin, Zuzana Tothova, Elizabeth A. Morgan, Benjamin L Ebert
Journal: Blood Advances
Blood Adv bloodadvances.2025016897.
https://doi.org/10.1182/bloodadvances.2025016897
Published: 2025
Includes: Supplemental data
Journal Articles

A revised prognostic model for patients with acute myeloid leukemia and first relapse

Open Access
Niek G. van der Maas, Dimitri Breems, Clara P. W. Klerk, Thomas Pabst, Patrycja Gradowska, Abin Thomas, Bart J. Biemond, Jurgen Kuball, Catharina H. M. J. Van Elssen, Otto Visser, Marie-Christiane Vekemans, Carlos Graux, Johan Maertens, Steven Knapper, Mike Dennis, Sylvie Freeman, Ian Thomas, H. Berna Beverloo, Gerwin Huls, Charles Craddock, Peter J. M. Valk, Paresh Vyas, Nigel Russell, Gert Ossenkoppele, Bob Löwenberg, Jan J. Cornelissen, Jurjen Versluis
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3853–3864.
https://doi.org/10.1182/bloodadvances.2025015797
Published: 2025
Includes: Supplemental data
Journal Articles

Drug development for leukemia: comprehensive analysis of clinical trials from first report to drug approval

Open Access
Clinical Trials & Observations
Kellen Cristine Tjioe, Marisol Miranda-Galvis, Kenza Mamouni, Thalyta Freitas, Muhannad Sharara, Brenda Santellano, Claudia Guillén-Lopez, Jorge E. Cortes
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3810–3813.
https://doi.org/10.1182/bloodadvances.2024014340
Published: 2025
Includes: Supplemental data
Journal Articles

Real-world effectiveness of immunoglobulin replacement for hypogammaglobulinemia and infections in multiple myeloma

Open Access
Elizabeth O’Donnell, Thais Gift, Zaid Yousif, Nikhil Khandelwal, Raj Desai, Lynn Huynh, Louise Clear, Megan Pinaire, Mingchen Ye, Azeem Banatwala, Gregory Belsky, Yichuan Grace Hsieh, Christopher Herrick, Mei Sheng Duh, Shawn N. Murphy, Marie Sanchirico
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3780–3789.
https://doi.org/10.1182/bloodadvances.2024015477
Published: 2025
Includes: Supplemental data
Journal Articles

RAS mutation identifies a poor prognostic molecular subtype of therapy-related myeloid neoplasm

Open Access
Chung Hoow Kok, Aref Al-Kali, Daniel Thomas, Rong He, Monika M. Kutyna, Hassan Alkhateeb, Kelly Lim, Antoine N. Saliba, Carla Toop, Aasiya Matin, Hamish Scott, Naseema Gangat, Anna Brown, Abhishek Mangaonkar, Christopher N. Hahn, Kebede Begna, Kevin Hung, Patricia Greipp, William J. Hogan, Mrinal Patnaik, Mithun Shah, Devendra K. Hiwase
Journal: Blood Advances
Blood Adv (2025) 9 (15): 3814–3818.
https://doi.org/10.1182/bloodadvances.2025016374
Published: 2025
Includes: Supplemental data