Skip to Main Content

Skip Nav Destination

RESEARCH LETTER| September 30, 2025

Luspatercept treatment affects immune regulatory subsets in subjects with MDS with Ring Sideroblasts

Stefania Leone,

Stefania Leone

1Hematopoietic Stem Cell Transplantation Unit, Azienda Ospedaliera A. Cardarelli, Naples, Italy

2Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy

https://orcid.org/0000-0002-5082-6367

Search for other works by this author on:

PubMed

Google Scholar

Francesco Grimaldi,

Francesco Grimaldi

2Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy

https://orcid.org/0000-0003-4365-9406

Search for other works by this author on:

PubMed

Google Scholar

Mara Memoli,

Mara Memoli

2Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy

Search for other works by this author on:

PubMed

Google Scholar

Giulia Scalia,

Giulia Scalia

3Clinical and Experimental Cytometry Unit, Centre for Advanced Biotechnology Franco Salvatore, CEINGE, Naples, Italy

Search for other works by this author on:

PubMed

Google Scholar

Annamaria Vincenzi,

Annamaria Vincenzi

2Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy

https://orcid.org/0009-0003-5975-9388

Search for other works by this author on:

PubMed

Google Scholar

Maria di Perna,

Maria di Perna

4Hematology, Hospital "Andrea Tortora", Pagani, Italy

Search for other works by this author on:

PubMed

Google Scholar

Giuseppe Cerciello,

Giuseppe Cerciello

2Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy

5Hematology, "San Pio" Hospital of Benevento, Benevento, Italy

Search for other works by this author on:

PubMed

Google Scholar

Antonio Vassallo,

Antonio Vassallo

6Department of Health Sciences, University of Basilicata, Potenza, Italy

https://orcid.org/0000-0001-7937-3309

Search for other works by this author on:

PubMed

Google Scholar

Fabrizio Pane,

Fabrizio Pane

2Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy

Search for other works by this author on:

PubMed

Google Scholar

Alessandra Picardi,

Alessandra Picardi

1Hematopoietic Stem Cell Transplantation Unit, Azienda Ospedaliera A. Cardarelli, Naples, Italy

7Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy

https://orcid.org/0000-0002-0136-7686

Search for other works by this author on:

PubMed

Google Scholar

Giuseppe Terrazzano,

Giuseppe Terrazzano

6Department of Health Sciences, University of Basilicata, Potenza, Italy

Search for other works by this author on:

PubMed

Google Scholar

Giuseppina Ruggiero,

Giuseppina Ruggiero

8Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy

Search for other works by this author on:

PubMed

Google Scholar

Flavia Carriero,

Flavia Carriero

6Department of Health Sciences, University of Basilicata, Potenza, Italy

https://orcid.org/0000-0003-3556-6891

Search for other works by this author on:

PubMed

Google Scholar

Valentina Rubino

Valentina Rubino

8Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy

https://orcid.org/0000-0002-5646-2795

Search for other works by this author on:

PubMed

Google Scholar

Blood Neoplasia 100170.

https://doi.org/10.1016/j.bneo.2025.100170

Key Points

Luspatercept in low-risk MDS-RS patients reduces high suppressive Tregs and mMDSC.
Low mMDSC levels and active CTL response may represent predictive markers for Luspatercept response in MDS-RS patients.

This content is only available as a PDF.

Author notes

Data Sharing: For original data, please contact valentina.rubino@unina.it

© 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

2025