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American Society of Hematology Self-Assessment Program, Ninth EditionAvailable to Purchase
Edited by
Brady L. Stein, MD,
Brady L. Stein, MD
Senior Executive Editor
Northwestern University
Chicago, Illinois
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Anand A. Patel, MD,
Anand A. Patel, MD
Associate Executive Editor
University of Chicago
Chicago, Illinois
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Jacquelyn M. Powers, MD, MS,
Jacquelyn M. Powers, MD, MS
Associate Editor—Medical Education and Multimedia
Baylor College of Medicine
Houston, Texas
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Catherine C. Smith, MD
Catherine C. Smith, MD
Associate Editor—Question Writing
University of California San Francisco
San Francisco, California
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American Society of Hematology
ISBN electronic:
978-0-9828435-4-3
Publication date:
2025
American Society of Hematology Self-Assessment Program, Ninth Edition
Edited by: Brady L. Stein, MD, Anand A. Patel, MD, Jacquelyn M. Powers, MD, MS, Catherine C. Smith, MD
https://doi.org/10.1182/ashsap9
ISBN (print): 978-0-9789212-9-3
ISBN (electronic): 978-0-9828435-4-3
Publisher: American Society of Hematology
Published: 2025
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Table of Contents
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Chapter 1: Consultative hematology 1: perioperative management conceptsByJordan Schaefer,Jordan SchaeferJordan Schaefer, MD, MSc Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MichiganSearch for other works by this author on:Geoffrey BarnesGeoffrey BarnesGeoffrey Barnes, MD, MSc Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MichiganSearch for other works by this author on:
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Chapter 2: Consultative hematology 2: outpatient hematology topicsByJennifer R. GreenJennifer R. GreenJennifer R. Green, MD Tennessee Oncology, Nashville, TennesseeSearch for other works by this author on:
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Chapter 3: Consultative hematology 3: women's health issuesByImo J. AkpanImo J. AkpanImo J. Akpan, MD Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, New YorkSearch for other works by this author on:
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Chapter 4: Pediatric hematology: selected topicsByShelley E. CraryShelley E. CraryShelley E. Crary, MD, MS University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, ArkansasSearch for other works by this author on:
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Chapter 5: Hematopoietic growth factorsByElizabeth A. GriffithsElizabeth A. GriffithsElizabeth A. Griffiths, MD Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkSearch for other works by this author on:
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Chapter 6: Iron physiology, iron overload, and the porphyriasByJason A. Freed,Jason A. FreedJason A. Freed, MD, Division of Hematology and Hematologic Malignancies, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MassachusettsSearch for other works by this author on:Rebecca Karp LeafRebecca Karp LeafRebecca Karp Leaf, MD, Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MassachusettsSearch for other works by this author on:
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Chapter 7: Acquired underproduction anemias: anemias in the setting of vitamin and mineral deficienciesByJacquelyn M. PowersJacquelyn M. PowersJacquelyn M. Powers, MD, MS Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TexasSearch for other works by this author on:
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Chapter 8: Anemia of inflammationByBrady L. SteinBrady L. SteinBrady L. Stein, MD, MHS Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School, of Medicine, Chicago, IllinoisSearch for other works by this author on:
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Chapter 9: Anemia in the setting of organ insult, systemic disease, and agingByMaria Domenica CappelliniMaria Domenica CappelliniMaria Domenica Cappellini, MD Fondazione IRCCS Ca’ Granda Policlinico, University of Milan, Milan, ItalySearch for other works by this author on:
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Chapter 10: Thalassemia syndromes and other hemoglobinopathiesBySujit ShethSujit ShethSujit Sheth, MD Division of Hematology/Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, New YorkSearch for other works by this author on:
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Chapter 11: Sickle cell diseaseByLydia H. PeckerLydia H. PeckerLydia H. Pecker, MD, MHS, Division of Hematology, Department of Medicine and Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MarylandSearch for other works by this author on:
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Chapter 12: Hemolytic anemia 1: autoimmune hemolysisBySamuel A. MerrillSamuel A. MerrillSamuel A. Merrill, MD, PhD, Division of Hematology/Oncology, Department of Medicine, West Virginia University, Morgantown, West VirginiaSearch for other works by this author on:
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Chapter 13: Hemolytic anemia 2: membrane abnormalities and enzymopathiesByRachael F. GraceRachael F. GraceRachael F. Grace, MD, MMSc, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MassachusettsSearch for other works by this author on:
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Chapter 14: Complement-related disordersByJamile M. ShammoJamile M. ShammoJamile M. Shammo, MD Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisSearch for other works by this author on:
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Chapter 15: Introduction to venous thromboembolism and antithrombotic drugsByJoseph J. ShatzelJoseph J. ShatzelJoseph J. Shatzel, MD, MCR Departments of Medicine and Biomedical Engineering, Oregon Health & Science University Portland, OregonSearch for other works by this author on:
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Chapter 16: Atypical-site thrombosisByCarol MathewCarol MathewCarol Mathew, MD Department of Medicine, University of Florida, Gainesville, FloridaSearch for other works by this author on:
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Chapter 17: Antiphospholipid syndromeByKarlyn A. MartinKarlyn A. MartinKarlyn A. Martin, MD Division of Hematology and Oncology, Department of Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VermontSearch for other works by this author on:
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Chapter 18: Cancer-associated thrombosisByAng LiAng LiAng Li, MD, MS, Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, TexasSearch for other works by this author on:
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Chapter 19: Inherited thrombophiliasByBethany T. Samuelson BannowBethany T. Samuelson BannowBethany Samuelson Bannow, MD, Hemostasis and Thrombosis Center and Knight Cancer Institute, Oregon Health & Science University, Portland, OregonSearch for other works by this author on:
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Chapter 20: von Willebrand diseaseByClay T. CohenClay T. CohenClay T. Cohen, MD, Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Cancer and Hematology Center, Houston, TexasSearch for other works by this author on:
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Chapter 21: Hemophilia A and BBySven OlsonSven OlsonSven Olson, MD, Division of Hematology/Medical Oncology, Oregon Health & Science University, Portland, OregonSearch for other works by this author on:
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Chapter 22: Hereditary hemorrhagic telangiectasia and other bleeding disordersByRaj S. Kasthuri,Raj S. KasthuriRaj S. Kasthuri, MBBS, Division of Hematology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North CarolinaSearch for other works by this author on:Hanny Al-SamkariHanny Al-SamkariHanny Al-Samkari, MD, Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MassachusettsSearch for other works by this author on:
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Chapter 23: Platelet disorders 1: immune thrombocytopeniaByTaylor Olmsted KimTaylor Olmsted KimTaylor Olmsted Kim, MD, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, CaliforniaSearch for other works by this author on:
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Chapter 24: Platelet disorders 2: heparin-induced thrombocytopenia and other anti-PF4 disordersByAndreas GreinacherAndreas GreinacherAndreas Greinacher, MD Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, GermanySearch for other works by this author on:
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Chapter 25: Platelet disorders 3: thrombotic thrombocytopenic purpura (immune and congenital)BySenthil SukumarSenthil SukumarSenthil Sukumar, MD, MS Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, TexasSearch for other works by this author on:
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Chapter 26: Platelet disorders 4: hereditary thrombocytopenia and qualitative platelet disordersByHanny AL-SamkariHanny AL-SamkariHanny Al-Samkari, MD Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MassachusettsSearch for other works by this author on:
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Chapter 27: Laboratory hematologyByKenneth D. Friedman,Kenneth D. FriedmanKenneth D. Friedman, MD Versiti/Blood Center of Wisconsin and Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WisconsinSearch for other works by this author on:Jason H. KurzerJason H. KurzerJason H. Kurzer, MD, PhD Department of Pathology, Stanford University School of Medicine, Stanford, CaliforniaSearch for other works by this author on:
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Chapter 28: Transfusion medicineByMichelle P. Zeller,Michelle P. ZellerMichelle P. Zeller, MD, FRCPC, MHPE, DRCPSC McMaster Centre for Transfusion Research McMaster University, Hamilton, Ontario, CanadaSearch for other works by this author on:Grace M. LeeGrace M. LeeGrace M. Lee, MD Department of Medicine, Duke University Medical Center, Durham, North CarolinaSearch for other works by this author on:
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Chapter 29: ApheresisByJay S. RavalJay S. RavalJay S. Raval, MD Department of Pathology and Laboratory Medicine Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VermontSearch for other works by this author on:
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Chapter 30: Hematopoietic cell transplantation and cellular therapy 1: the basics of transplantationByChristopher R. D'AngeloChristopher R. D'AngeloChristopher D'Angelo, MD Division of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NebraskaSearch for other works by this author on:
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Chapter 31: Hematopoietic cell transplantation and cellular therapy 2: autologous transplantationByBenjamin A. DermanBenjamin A. DermanBenjamin A. Derman, MD Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IllinoisSearch for other works by this author on:
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Chapter 32: Hematopoietic cell transplantation and cellular therapy 3: allogeneic transplantation and graft-versus-host diseaseByShernan HoltanShernan HoltanShernan Holtan, MD Blood and Marrow Transplantation Section, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkSearch for other works by this author on:
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Chapter 33: Hematopoietic cell transplantation and cellular therapy 4: adoptive cellular therapyByMelody SmithMelody SmithMelody Smith, MD, MS Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CaliforniaSearch for other works by this author on:
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Chapter 34: Myeloid disorders: acquired and inherited white blood cell disordersByBhumika J. PatelBhumika J. PatelBhumika J. Patel, MDTranslational Hematology and Oncology, Prisma Health Cancer Institute, Greenville, South CarolinaSearch for other works by this author on:
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Chapter 35: Inherited bone marrow failure syndromesByMichael W. DrazerMichael W. DrazerMichael W. Drazer, MD, PhD Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IllinoisSearch for other works by this author on:
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Chapter 36: Chronic myeloid leukemiaByMaximilian StahlMaximilian StahlMaximilian Stahl, MD Section of Medical Oncology and Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, ConnecticutSearch for other works by this author on:
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Chapter 37: Myeloproliferative neoplasms: polycythemia vera, essential thrombocythemia, and myelofibrosisByBrady Stein,Brady SteinBrady L. Stein, MD, MHS Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisSearch for other works by this author on:Anand A. PatelAnand A. PatelAnand A. Patel, MD Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IllinoisSearch for other works by this author on:
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Chapter 38: Beyond the classical Philadelphia chromosome–negative myeloproliferative neoplasmsByAnand A. Patel,Anand A. PatelAnand A. Patel, MD Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IllinoisSearch for other works by this author on:Brady SteinBrady SteinBrady L. Stein, MD, MHS Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School, of Medicine, Chicago, IllinoisSearch for other works by this author on:
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Chapter 39: Acquired bone marrow failure syndromes, including aplastic anemia and pure red cell aplasiaByEmma M. GroarkeEmma M. GroarkeEmma M. Groarke, MB BCh BAO, MD Hematopoiesis and Bone Marrow Failure, Laboratory Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MarylandSearch for other works by this author on:
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Chapter 40: Myelodysplastic syndromes and premalignant clonal hematopoiesisByLachelle D. WeeksLachelle D. WeeksLachelle D. Weeks, MD, PhD Center for Early Detection and Interception of Blood Cancers and Center for Adult Leukemia, Division of Hematologic Malignancies Dana-Farber Cancer Institute, Division of Population Sciences, Department of Medical Oncology Dana-Farber Cancer Institute and Department of Medicine Harvard Medical School, Boston, MassachusettsSearch for other works by this author on:
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Chapter 41: Acute myeloid leukemiaByCatherine C. SmithCatherine C. SmithCatherine C. Smith, MD Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CaliforniaSearch for other works by this author on:
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Chapter 42: Acute lymphoblastic leukemiaByLori MufflyLori MufflyLori Muffly, MD, MS Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CaliforniaSearch for other works by this author on:
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Chapter 43: Hodgkin lymphomaByMatthew MeiMatthew MeiMatthew Mei, MD Division of Lymphoma, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CaliforniaSearch for other works by this author on:
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Chapter 44: Indolent non-Hodgkin B-cell lymphomaBySairah AhmedSairah AhmedSairah Ahmed, MD Departments of Lymphoma and Stem Cell Transplant, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TexasSearch for other works by this author on:
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Chapter 45: Aggressive non-Hodgkin and Burkitt lymphomasByAllison RosenthalAllison RosenthalAllison Rosenthal, DO Mayo Clinic Phoenix, ArizonaSearch for other works by this author on:
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Chapter 46: T-cell lymphomasByNeha Mehta-ShahNeha Mehta-ShahNeha Mehta-Shah, MD, MSCI Division of Oncology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MissouriSearch for other works by this author on:
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Chapter 47: Chronic lymphocytic leukemia/small lymphocytic lymphomaByJennifer A. WoyachJennifer A. WoyachJennifer A. Woyach, MD Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OhioSearch for other works by this author on:
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Chapter 48: Plasma cell disorders: monoclonal gammopathy of undetermined significance and multiple myelomaByCaitlin L. CostelloCaitlin L. CostelloCaitlin Costello, MD Division of Blood and Marrow Transplantation, Moores Cancer Center, University of California, San Diego, La Jolla, CaliforniaSearch for other works by this author on:
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Chapter 49: AL amyloidosis, Waldenström macroglobulinemia, and POEMS syndromeByVaishali SanchorawalaVaishali SanchorawalaVaishali Sanchorawala, MD Department of Medicine, Amyloidosis Center, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, MassachusettsSearch for other works by this author on: