Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is the most common subtype of large B-cell lymphoma, with differences in prognosis reflecting heterogeneity in the pathological, molecular, and clinical features. Current treatment standard is based on multiagent chemotherapy, including anthracycline and monoclonal anti-CD20 antibody, which leads to cure in 60% of patients. Recent years have brought new insights into lymphoma biology and have helped refine the risk groups. The results of these studies inspired the design of new clinical trials with targeted therapies and response-adapted strategies and allowed to identify groups of patients potentially benefiting from new agents. This review summarizes recent progress in identifying high-risk patients with DLBCL using clinical and biological prognostic factors assessed at diagnosis and during treatment in the front-line setting, as well as new treatment strategies with the application of targeted agents and immunotherapy, including response-adapted strategies.
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HIGH-RISK AGGRESSIVE LYMPHOMA|
December 19, 2024
DLBCL: who is high risk and how should treatment be optimized?
Anna Dabrowska-Iwanicka,
Anna Dabrowska-Iwanicka
1Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
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Grzegorz S. Nowakowski
Grzegorz S. Nowakowski
2Division of Hematology, Mayo Clinic, Rochester, MN
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Blood (2024) 144 (25): 2573–2582.
Article history
Submitted:
July 10, 2023
Accepted:
October 24, 2023
First Edition:
November 3, 2023
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Citation
Anna Dabrowska-Iwanicka, Grzegorz S. Nowakowski; DLBCL: who is high risk and how should treatment be optimized?. Blood 2024; 144 (25): 2573–2582. doi: https://doi.org/10.1182/blood.2023020779
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December 19 2024
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