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Research Article December 18 2025

p27Kip1 regulates γ-globin production

Ginette Balbin-Cuesta,Claire Drysdale,Claire Kerpet,Lei Yu,Greggory Myers,Zesen Lin,Beth McGee,Ann Friedman,Xiaofeng Liu,Sharon A. Singh,James Douglas Engel,Laura Buttitta,Rami Khoriaty

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Research Article December 18 2025

Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy

Ruomei Cheng,Xiaopeng Tang,Xiaoshan Huang,Xudong Dong,Yifan Chen,Jinai Gao,Long Bai, II,Dawit Adisu Tadese,Quxi Zhao,Meiquan Li,Deyuan Su,Qiumin Lu,Ziyi Wang,Ren Lai

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Research Article December 18 2025

Circulating tumor cells in myeloma are a compound biomarker for bone marrow high-risk genomic alterations and tumor load

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Review Article December 18 2025

Posttransplant Cyclophosphamide in HLA-matched Peripheral Blood Transplantation: What's next?

David J Curtis,Geoffrey R Hill

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Research Article December 17 2025

The role of CD38 in monocytes during fibrotic progression of myeloproliferative neoplasms

Yiru Yan,Jinqin Liu,Songyang Zhao,Fuhui Li,Lin Yang,Zefeng Xu,Tiejun Qin,Xiaofan Zhu,Wenbin An,Zhongxun Shi,Wenyi Shen,Peihong Zhang,Gang Huang,Raajit K. Rampal,Zhijian Xiao,Bing Li

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Brief Report December 17 2025

The glycosaminoglycan oncofetal chondroitin sulfate represents a novel target for antibody drug-conjugate therapy for AML

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Research Article December 17 2025

Selective depletion of B-cell subsets underlies increased risk of infection in MM patients treated with anti-BCMA vs -GPRC5D bsAbs

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Research Article December 17 2025

A Decade of Ibrutinib for CLL with and without TP53 Aberration: Final Report on an Investigator-Sponsored Phase 2 Study

Andy Itsara,Victoria M. Rogness,Laura Samples,Constance M. Yuan,Hao-Wei Wang,Inhye E. Ahn,Mohammed Z.H. Farooqui,Xin Tian,Clare Sun,Emily Tomasulo,Susan Soto,Jeanine Superata,Larisa Bezkorovaynaya,Thomas E. Hughes,Pia K. Nierman,Adrian Wiestner

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Research Article December 17 2025

PD-1-based combinations before autologous transplant are associated with improved outcomes in classical Hodgkin lymphoma

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Research Article December 15 2025

Pharmacological Inhibition of miR-126 Enhances Venetoclax Activity in Acute Myeloid Leukemia

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Review Article December 15 2025

2025 Update on MRD in Acute Myeloid Leukemia: A Consensus Document from the ELN-DAVID MRD Working Party

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Research Article December 15 2025

Asciminib Demonstrates Superior Efficacy and Safety in Newly Diagnosed Chronic Myeloid Leukemia in the ASC4FIRST Trial

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Research Article December 15 2025

Microenvironmental cell interactions are essential for sustaining functionality of myelofibrosis malignant stem cells

Min Lu,Md. Babu Mia,Lijuan Xia,Gohar Mosoyan,Momina Hayat,Christoph Schaniel,Ronald Hoffman

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Research Article December 15 2025

Transient SP140 inhibition unlocks hematopoietic stem cell fate from human pluripotent stem cells

Xingjie Liu,Zhiwei Zhang,Xinyu Cui,Rui Guo,Xiaoyan Ding,Liyang Ma,Pentao Liu,Yong Yu

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Review Article December 15 2025

Methylation-based lineage tracing in cancer

Jiaoyi Chen,Benson Z Wu,Federico Gaiti

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Research Article December 12 2025

Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial

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Research Article December 10 2025

CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis

Joseph M. Rocco,Joseph H. Oved,Rikita J Patel,A Zara Herskovits,Namitha Nair,Bita Shakoory,Thomas Robertson,Rachel Dileo,Max W Jacobs,Christa Zerbe,Rachael Gordon,Michael Joseph Ombrello,Amanda K Ombrello,Nirali N Shah,Dimana Dimitrova,Jennifer A Kanakry,Andrew D. Zelenetz,Alison J Moskowitz,Robert N Stuver,Zachary D Epstein-Peterson,Paola Ghione,Elena Mead,Zainab Shahid,Sergio A. Giralt,Sandeep S Raj,Jae H Park,Ivan Maillard,Mark B. Geyer,Wenbin Xiao,Ahmet Dogan,Megan S Lim,Jeffrey I. Zwicker,Jodi V. Mones,Rehka Parameswaran,Lauren G Banaszak,Shamir Geller,Bianca D. Santomasso,Roni Shouval,Kevin J. Curran,Ottavia M Delmonte,Luigi D Notarangelo,Jeffrey I Cohen,Steven M. Holland,Gilles A. Salles,Steven M Horwitz,Santosha A Vardhana,Miguel-Angel Perales,Daniella Schwartz,Irini Sereti,William T. Johnson

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Research Article December 8 2025

Early time to relapse as a survival prognosticator in mature T-cell/NK-cell lymphomas: results from the PETAL Consortium

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Review Article December 8 2025

Evolution of Multiple Myeloma from a Genomic Perspective

Francesco Maura,Mehmet K. Samur,Nikhil C. Munshi

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Research Article December 8 2025

Azacitidine to treat measurable residual disease in patients with MDS/AML: final long-term results of the RELAZA2 trial

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Research Article December 8 2025

Increased Prevalence of Clonal Hematopoiesis in Children with Sickle Cell Disease

Jessica Ulloa,Kristin Wuichet,Sara R Rashkin,Yash Pershad,Connor Shore,Caitlyn Vlasschaert,Mark J. Rodeghier,Yu Yao,Victor R Gordeuk,Binal N Shah,Clifford M. Takemoto,Santosh L Saraf,Michael R DeBaun,Mitchell J. Weiss,Alexander G. Bick

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Research Article December 8 2025

Immune thrombocytopenia in patients treated with immune checkpoint inhibitors

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Research Article December 6 2025

Efficacy and Safety of Marstacimab Prophylaxis in Hemophilia A/B With Inhibitors: Results from the Phase 3 BASIS Trial

Davide Matino,Suchitra Acharya,Carrie Turich Taylor,Pengling Sun,Delphine Agathon,Sangeeta Raje,Travis Gould,Andrew Palladino,Johnny Mahlangu

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Research Article December 4 2025

Belantamab mafodotin, lenalidomide and dexamethasone (BelaRd) in newly diagnosed intermediate-fit and frail myeloma

Evangelos Terpos,Maria Gavriatopoulou,Ioannis Ntanasis-Stathopoulos,Panos Malandrakis,Despina Fotiou,Nikolaos Kanellias,Magdalini Migkou, Dr,Foteini Theodorakakou,Vasiliki Spiliopoulou,Irene Solia,Evangelos Eleutherakis-Papaiakovou,Giorgos Psarros,Efstathios Kastritis,Meletios A Dimopoulos

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Research Article December 4 2025

Lipid nanotubes unmask neutrophils for complement attack

Xiaobo Liu,Yuanyuan Wang,Alexander Thomas Bauer,Alex Marki,Christian F. Krebs,Karsten Häffner,Bente Siebels,Hartmut Schlüter,Frank Hildebrand,Rebecca Halbgebauer,Markus S Huber-Lang,Klaus Ley,Matthias F Schneider,Stefan Werner Schneider,Christian Gorzelanny

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Review Article December 2 2025

How I Treat Advanced Phases of CML

Michael J. Mauro

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Research Article December 1 2025

NLRP3 inflammasome blockade treats intestinal inflammation associated with chronic granulomatous disease.

Emma Darbinian,Kodjovi D. Mlaga,Matheus Aranguren,Aléhandra Desjardins,Evelyne Martineau,Chantal Massé,Jennifer W Leiding,Johanne Poudrier,Emilia Liana Falcone

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Review Article November 25 2025

Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives

Erik Müller,Bastian Kruse,Jan P Böttcher

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Review Article November 25 2025

Hemophagocytic Lymphohistiocytosis in Adults

Joanne Ino Hsu,Sarah Nikiforow,Nancy Berliner

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Letter November 25 2025

Somatic genetic rescue in ZCCHC8-associated telomere biology disorders

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Research Article November 25 2025

Long-term Follow-up of Gastrointestinal CAR T-cell Lymphoma: Homing, Clonal Expansion, and Response to Cyclosporine

Hitomi Hosoya,Armando N Bastidas Torres,Sebastian Fernandez-Pol,John Mark Gubatan,Safa Najidh,George E Duran,Fei Dong,Zachary Ehlinger,Claire Lohman,Charles Wright, III,Bita Sahaf,Crystal L. Mackall,David B Miklos,Surbhi Sidana,David M Kurtz,Michael S Khodadoust,Lehka Mikkilineni

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Research Article November 24 2025

IFN-γ increases δ-globin gene expression through activation of the JAK/STAT pathway in erythroid cells

Jianqiong Zhu,Kyung Chin,Jizhong Zou,Wulin Aerbajinai,Wan-Chi Lin,Hongzhen Li,Griffin P Rodgers

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Letter November 24 2025

Prior transplantation and idecabtagene vicleucel in multiple myeloma: a secondary analysis of CIBMTR data

Rahul Banerjee,Christy Khouderchah,Othman Salim Akhtar,Emily C. Liang,Jordan Gauthier,Madhav V. Dhodapkar,Andrew J. Portuguese

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Research Article November 24 2025

Multisite Validation of a Venous Thrombosis Risk Model in Critically Ill Children Through the CHAT Consortium

Julie Jaffray,Brian R Branchford,Maua Mosha Alleyne,Ernest Amankwah,E. Vincent S. Faustino,Neil A Zakai,Anthony A. Sochet,Amy Stillings,Emily Krava,Guy Young,Neil A Goldenberg

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Research Article November 24 2025

Platelet defects in patients and mice with Ehlers-Danlos syndrome

Mariia Kumskova,Gagan D Flora,Manasa K. Nayak,Ivan Budnik,Aditi Jain,Rakesh B. Patel,Abhishek B Jha,Madankumar Ghatge,Neelam Chauhan,James V. Michael,Steven E. McKenzie,Anjali Sharathkumar,Janice M Staber,Steven R Lentz,Anil Chauhan

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Research Article November 21 2025

Gene expression profiling reveals two overarching types of ALCL with distinct targetable biology: an LLMPP study

Andrew L. Feldman,Surendra Dasari,Lisa M. Rimsza,David W. Scott,Naoki Oishi,Guangzhen Hu,Pedro Farinha,Catalina Amador,Elías Campo,Wing C. Chan,James R. Cook,Jan Delabie,Kai Fu,Timothy C Greiner,Laura K Hilton,Giorgio GA Inghirami,Javeed Iqbal,Elaine S Jaffe,Ryan Morin,Sarah L. Ondrejka,German Ott,Stefania Pittaluga,Philipp W Raess,Andreas Rosenwald,Kerry J. Savage,Graham W. Slack,Susan L. Slager,Joo Y Song,George Wright,Hao-Wei Wang,Yu Zeng,Tadashi Yoshino,Xiaojun Wu,Ryan A Wilcox,xueju wang,Min Shi,Akira Satou,Anamarija M Perry,Roberto Nicolas Miranda,L.Jeffrey Jeffrey Medeiros,Matthew J Maurer,Eric Mou,Young Hyeh Ko,Kennosuke Karube,Brad S Kahl,Liuyan Jiang,David L Jaye,Alejandro Gru,Laurence L de Leval,Weina Chen,Jennifer R. Chapman,James R Cerhan,Carlos Barrionuevo,Stephen M. Ansell,Ahmed Aljudi

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Research Article November 19 2025

Outcome of children with B-cell acute lymphoblastic leukemia with hypodiploidy or BCR::ABL1 fusion undergoing allogeneic HSCT

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Research Article November 14 2025

Integrin αvβ8-mediated TGF-β1 activation regulates sustained response in immune thrombocytopenia after TPO-RA withdrawal

Heng Mei,Min Xu,Jinhui jin Shu,Lu Tang,Qinying Xie,Lili Luo,Qiuzhe Wei,Huiwen Jiang,Zhangyin Ming,Yu Hu

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Research Article November 14 2025

CPX-351 versus daunorubicin, cytarabine plus gemtuzumab ozogamicin in older adults with non-adverse risk AML: NCRI AML18

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Research Article November 14 2025

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation

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Research Article November 14 2025

Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex

Abhirup Bagchi,Sindhu Billakanti,Vanessa Shehu,Kathryn M. Farrell,Sarah A. Cotteta,Bailey N. Godfrey,Micaela Alpert,Jacob Flores Zeranski,Krista A. Budinich,Zhuangzhuang Geng,Osheiza Abdulmalik,Belinda M. Giardine,Cheryl A. Keller,Ross C. Hardison,Junwei Shi,Eugene Khandros

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Letter November 10 2025

Utility of Peripheral Blood Testing for Detection and Surveillance of Clonal Hematopoiesis in Predisposed Individuals (CH-IPI)

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Research Article November 10 2025

Impact of TP53 mutations and their variant allele frequency in adults with newly diagnosed acute lymphoblastic leukemia

Roberta S. Azevedo,Elias Jabbour,Hagop M Kantarjian,Sravanthi Lavu,Sanam Loghavi,Nitin Jain,Koji Sasaki,Rebecca Garris,Koichi Takahashi,Farhad Ravandi,Nicholas J. Short

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Research Article November 6 2025