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Journal Articles

Measurable Residual Disease by Mass Spectrometry and Next-Generation Flow to Assess Treatment Response in Myeloma

Noemi Puig, Cristina Agullo Roca, Teresa Contreras Sanfeliciano, M Teresa Cedena, Joaquín Martínez-López, Albert Oriol, María-Jesús Blanchard, Rafael Ríos-Tamayo, Belén Iñigo Rodríguez, Anna Sureda, Sunil Lakhwani, Javier de la Rubia Comos, Veronica Gonzalez-Calle, Valentín Cabañas, Luis Palomera, José María M Moraleda, Joan Bargay, Sergio Castro, Laura Rosiñol, Joan Bladé, Jesús F. San-Miguel, Juan-Jose Lahuerta, Bruno Paiva, Maria-Victoria Mateos
Journal: Blood
Blood blood.2024024995.
https://doi.org/10.1182/blood.2024024995
Published: 2024
Includes: Supplemental data
Journal Articles

Predictors of unsustained measurable residual disease negativity in transplant-eligible patients with multiple myeloma

Clinical Trials & Observations Brief Report
Camila Guerrero, Noemi Puig, María-Teresa Cedena, María-José Calasanz, Norma C. Gutierrez, Manuela Fernandez, Albert Oriol, Rafael Ríos-Tamayo, Miguel-Teodoro Hernandez, Rafael Martínez-Martínez, Joan Bargay, Felipe de Arriba, Luis Palomera, Ana Pilar Gonzalez-Rodriguez, Marta-Sonia Gonzalez Perez, Alberto Orfao, María-Victoria Mateos, Joaquin Martinez-Lopez, Laura Rosiñol, Joan Bladé, Juan-Jose Lahuerta, Jesus F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2024) 143 (7): 597–603.
https://doi.org/10.1182/blood.2023022083
Published: 2024
Includes: Supplemental data
Journal Articles

Preclinical and Translational Biomarker Analyses to Inform Clinical Development of Mezigdomide (CC-92480) in Combination with Dexamethasone and Daratumumab in Multiple Myeloma

Tracy T. Chow, Michael Amatangelo, Peilin Ma, Chad C. Bjorklund, Krista Wollerman, Tiziana Civardi, Phillip Koo, Yue Zhu, Paulo Maciag, Jessica Katz, Aparna Raval, Albert Oriol, Robert Z. Orlowski, Darrell White, Paul G. Richardson, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3318.
https://doi.org/10.1182/blood-2023-178881
Published: 2023
Journal Articles

Results from the Completed Dose Escalation Portion of the Phase 1 Study of HPN217, a Half-Life Extended Tri-Specific T Cell Activating Construct (TriTAC®) Targeting B Cell Maturation Antigen (BCMA) for Relapsed/Refractory Multiple Myeloma (MM)

Sumit Madan, Caitlin L. Costello, Brea Lipe, Andrew J. Cowan, Eva Medvedova, Jens Hillengass, P. Leif Bergsagel, Xavier Leleu, Cyrille Touzeau, Daniel Morillo, Albert Oriol, Raya Mawad, Henning Schade, Salomon Manier, Yifah Yaron, Banmeet Anand, Al-Ola Abdallah
Journal: Blood
Blood (2023) 142 (Supplement 1): 1012.
https://doi.org/10.1182/blood-2023-182345
Published: 2023
Journal Articles

Carfilzomib, Daratumumab, and Dexamethasone (KdD) Vs Carfilzomib and Dexamethasone (Kd) for Relapsed/Refractory Multiple Myeloma (RRMM) in the Phase 3 Candor Study: Subgroup Analysis According to Renal Functioning

Meletios Athanasios Dimopoulos, Ola Landgren, David S. Siegel, Sebastian Grosicki, Albert Oriol, Rani Najdi, Chuang Li, Khalid Mezzi, Natalie Shu, Hang Quach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2021.
https://doi.org/10.1182/blood-2023-190726
Published: 2023
Journal Articles

Longitudinal Screening of Mutant Hematopoietic Progenitor Cells (HPC) in Multiple Myeloma (MM) and Its Association with Secondary Primary Malignancies (SPM)

Cristina Perez, Maria Jose Larrayoz, Iria Vazquez, Irache Erdozain, Noemi Puig, María T Cedena, Catarina Maia, Amagoia Mañu, Natalia Gordillo, Oihane Churruca, Diego Alignani, Sarai Sarvide, Albert Oriol Rocafiguera, Laura Rosiñol, Rafael Ríos, Marta Sonia Gonzalez Perez, Ana Pilar Gonzalez-Rodriguez, Felipe De Arriba, Jose Maria Moraleda, Jesus Martin Sanchez, Luis Palomera, Valentin Cabanas Perianes, Maria Jose Calasanz, Joaquin Martinez-Lopez, Maria Victoria Mateos, Joan Bladé, Juan Jose Lahuerta Palacios, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 533.
https://doi.org/10.1182/blood-2023-185737
Published: 2023
Journal Articles

Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma

Clinical Trials & Observations
Laura Rosiñol, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Miguel Teodoro Hernández, Valentín Cabañas, Estrella Carrillo-Cruz, Anna Sureda, Joaquín Martínez-López, Isabel Krsnik, Maria Esther González, Luis Felipe Casado, Josep María Martí, Cristina Encinas, Felipe de Arriba, Luis Palomera, Antonia Sampol, Yolanda González-Montes, Elena Cabezudo, Bruno Paiva, Noemí Puig, María Teresa Cedena, Javier de la Cruz, María-Victoria Mateos, Jesús San Miguel, Juan José Lahuerta, Joan Bladé
Journal: Blood
Blood (2023) 142 (18): 1518–1528.
https://doi.org/10.1182/blood.2022019531
Published: 2023
Journal Articles

Alnuctamab (ALNUC; BMS-986349; CC-93269), a 2+1 B-Cell Maturation Antigen (BCMA) × CD3 T-Cell Engager (TCE), Administered Subcutaneously (SC) in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from a Phase 1 First-in-Human Clinical Study

Noffar Bar, Maria Victoria Mateos, Paz Ribas, Markus Hansson, Laura Paris, Craig C. Hofmeister, Paula Rodriguez Otero, Maria Aranzazu Bermúdez, Thomas Martin, Armando Santoro, Andrew J. Yee, Maria Creignou, Cristina Encinas Rodriguez, Claudio Cerchione, Javier De La Rubia, Albert Oriol, Heidi Waibel, Britta Besemer, Ethan Thompson, Brian Kiesel, Jinjie Chen, Alexander Chung, Isaac W. Boss, Allison Gaudy, Shaoyi Li, Kevin Hsu, Colin Godwin, Michael R. Burgess, Jesús San-Miguel, Luciano Costa
Journal: Blood
Blood (2023) 142 (Supplement 1): 2011.
https://doi.org/10.1182/blood-2023-180013
Published: 2023
Journal Articles

Mezigdomide (MEZI) Plus Dexamethasone (DEX) and Daratumumab (DARA) or Elotuzumab (ELO) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Results from the CC-92480-MM-002 Trial

Paul G. Richardson, Irwindeep Sandhu, Craig C. Hofmeister, Robert Z. Orlowski, Darrell White, Angelo Belotti, Charlotte Toftmann Hansen, Noopur S. Raje, Tracy T. Chow, Zehua Zhou, Tiziana Civardi, Phillip Koo, Yue Zhu, Jessica Katz, Albert Oriol
Journal: Blood
Blood (2023) 142 (Supplement 1): 1013.
https://doi.org/10.1182/blood-2023-174443
Published: 2023
Journal Articles

The Impact of Isatuximab Regimens on Hypogammaglobulinemia Occurrence, Recovery, and Associated Infections in Patients with Relapsed/Refractory Multiple Myeloma

Cesar Rodriguez, Aurore Perrot, Paul G. Richardson, Thierry Facon, Ivan Spicka, Albert Oriol, Kenshi Suzuki, Edvan Crusoe, Ajai Chari, Nicole Armstrong, Christina Tekle, Marie-Laure Risse, Thomas Martin, Philippe Moreau
Journal: Blood
Blood (2023) 142 (Supplement 1): 1980.
https://doi.org/10.1182/blood-2023-179925
Published: 2023
Journal Articles

Symptoms, Functioning, and Health-Related Quality of Life in Patients with Relapsed/Refractory Multiple Myeloma Treated with Talquetamab: Updated Patient-Reported Outcomes from the Phase 1/2 MonumenTAL-1 Study

Carolina Schinke, Cyrille Touzeau, Albert Oriol, María-Victoria Mateos, Don A. Stevens, Leo Rasche, Xiang Qin, Kelly Kato, Timothy Ming, Eva G Katz, Katharine S Gries, Michela Campagna, Tara J Masterson, Brandi W Hilder, Jaszianne Tolbert, Thomas Renaud, Christoph Heuck, Philippe Moreau, Jesús San-Miguel, Paula Rodríguez Otero, Ajai Chari
Journal: Blood
Blood (2023) 142 (Supplement 1): 6711.
https://doi.org/10.1182/blood-2023-189151
Published: 2023
Journal Articles

GEM2017FIT Trial: Induction Therapy with Bortezomib-Melphalan and Prednisone (VMP) Followed By Lenalidomide and Dexamethasone (Rd) Versus Carfilzomib, Lenalidomide and Dexamethasone (KRd) Plus/Minus Daratumumab (D), 18 Cycles, Followed By Consolidation and Maintenance Therapy with Lenalidomide and Daratumumab: Phase III, Multicenter, Randomized Trial for Elderly Fit Newly Diagnosed Multiple Myeloma (NDMM) Patients Aged between 65 and 80 Years

Maria-Victoria Mateos, Bruno Paiva, Maria Teresa Cedena Romero, Noemi Puig, Anna Maria Sureda Balari, Albert Oriol, Enrique M Ocio, Laura Rosiñol, Yolanda González-Montes, Juan Jose Bargay, Esther Gonzalez Garcia, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado Montero, Valentin Cabanas Perianes, Jaime Pérez De Oteyza, Mercedes Gironella, Joaquin Martinez-Lopez, Ana-Isabel -Teruel, Pilar Delgado, Elena Prieto, Juan Jose Lahuerta Palacios, Joan Bladé, Jesus San Miguel
Journal: Blood
Blood (2023) 142 (Supplement 1): 209.
https://doi.org/10.1182/blood-2023-179866
Published: 2023
Journal Articles

Sustained Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Discriminates Patients with Sustained Negative Minimal Residual Disease

Sunil Lakhwani, Laura Rosiñol, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquin Martinez Lopez, Bruno Paiva, Maria Teresa Cedena Romero, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Maria Sureda Balari, Isabel Krsnik, Esther Gonzalez Garcia, Luis Felipe Casado Montero, Josep Maria Marti Tutusaus, Cristina Encinas Rodriguez, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Cristina Motlló, Javier De la Cruz, Rafael Alonso Fernández, Maria-Victoria Mateos, Joan Blade Creixenti, Juan Jose Lahuerta Palacios, Jesus San Miguel, Miguel Teodoro Hernández Garcia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1958.
https://doi.org/10.1182/blood-2023-179452
Published: 2023
Journal Articles

Minimally Invasive Assessment of Measurable Residual Disease (MRD) in Multiple Myeloma (MM)

Carmen Gonzalez, Marta Lasa, Laura Notarfranchi, Cristina Agullo, Natalia Buenache Cuenda, Anastasiia Zherniakova, Sergio Castro, José Juan Pérez, Veronica Gonzalez-Calle, Maria Teresa Cedena Romero, Santiago Barrio, Alejandro Martín-Muñoz, Leire Burgos, Diego Alignani, Maria Jose Calasanz, Paula Rodriguez Otero, Laura Rosiñol, Felipe De Arriba, Enrique M Ocio, Albert Oriol Rocafiguera, Luis Palomera, Yolanda González-Montes, Anna Maria Sureda Balari, Miguel Teodoro Hernandez Garcia, Maria Esther Clavero Sanchez, Angela Ibanez Garcia, Clara Gomez, Alberto Orfao, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Joan Bladé, Jesus San-Miguel, Joaquin Martinez-Lopez, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 339.
https://doi.org/10.1182/blood-2023-186916
Published: 2023
Journal Articles

Biological and Clinical Significance of Undetectable Circulating Tumor Cells (CTCs) in Patients (Pts) with Multiple Myeloma (MM)

Juan-José Garcés, Rosalinda Termini, Esperanza Martín-Sánchez, Marta Lasa, Jose J Perez, Norma C. Gutierrez, Manuela Fernández, Maria Jose Calasanz, Laura Rosiñol, Miguel Teodoro Hernández Garcia, Albert Oriol, Anna Maria Sureda Balari, Albert Perez Montaña, Enrique M Ocio, Maria Casanova Espinosa, Felipe Prosper, Joaquin Martinez-Lopez, Jorge Labrador, Esther Gonzalez Garcia, Rafael Ríos, Fernando Escalante, Joan Bargay, Elena Cabezudo, Valentín Cabañas, Niels Weinhold, Aldo Roccaro, Herve Avet-Loiseau, Alberto Orfao, Joan Blade Creixenti, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Jesus San-Miguel, María T Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 646.
https://doi.org/10.1182/blood-2023-186411
Published: 2023
Journal Articles

Isolated and Dynamic Peripheral Blood Residual Disease Status Characterized By Mass Spectrometry Predicts Outcome in Patients with High Risk Smoldering Multiple Myeloma Treated in the GEM-CESAR Trial

Noemi Puig, Cristina Agullo, Teresa Contreras, Bruno Paiva, Maria Teresa Cedena Romero, José Juan Pérez, Irene Aires, Joaquin Martinez-Lopez, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Marta Sonia Gonzalez Perez, Norma C. Gutierrez, Albert Oriol Rocafiguera, Rafael Ríos, Laura Rosiñol, Miguel Angel Alvarez Rivas, Maria Jose Calasanz, Bargay Joan, Ramon Garcia-Sanz, Ana Pilar Gonzalez, Adrián Alegre, Fernando Escalante, Rafael Martínez, Javier De La Rubia, Ana Isabel Teruel, Felipe De Arriba, Luis Palomera, Sergio Castro, Miguel Teodoro Hernández Garcia, Javier López, Aránzazu García Mateo, Enrique M Ocio, Joan Bladé, Juan Jose Lahuerta Palacios, Jesús San Miguel, Maria Victoria Mateos
Journal: Blood
Blood (2023) 142 (Supplement 1): 645.
https://doi.org/10.1182/blood-2023-182964
Published: 2023
Journal Articles

Results of the Phase III Randomized Iskia Trial: Isatuximab-Carfilzomib-Lenalidomide-Dexamethasone Vs Carfilzomib-Lenalidomide-Dexamethasone As Pre-Transplant Induction and Post-Transplant Consolidation in Newly Diagnosed Multiple Myeloma Patients

Francesca Gay, Wilfried Roeloffzen, Meletios A. Dimopoulos, Laura Rosiñol, Marjolein van der Klift, Roberto Mina, Albert Oriol Rocafiguera, Eirini Katodritou, Ka Lung Wu, Paula Rodriguez Otero, Roman Hajek, Elisabetta Antonioli, Mark van Duin, Mattia D'Agostino, Joaquin Martinez-Lopez, Elena M. van Leeuwen-Segarceanu, Paola Tacchetti, Niels W.C.J. van de Donk, Katja Weisel, Luděk Pour, Jakub Radocha, Angelo Belotti, Fredrik Schjesvold, Joan Bladé, Hermann Einsele, Pieter Sonneveld, Mario Boccadoro, Annemiek Broijl
Journal: Blood
Blood (2023) 142 (Supplement 1): 4.
https://doi.org/10.1182/blood-2023-177546
Published: 2023
Journal Articles

Kinetics and Biology of Circulating Tumor Cells (CTCs) and Measurable Residual Disease (MRD): Two Dynamic High-Risk Clones in Multiple Myeloma (MM)

Camila Guerrero, Rosalinda Termini, Juan-José Garcés, Maria Jose Calasanz, Rafael Ríos, Elena Cabezudo, Laura Rosiñol, Bargay Joan, Albert Pérez-Montaña, Albert Oriol Rocafiguera, Valentin Cabanas Perianes, Maria-Josefa Najera, Esther Gonzalez Garcia, Enrique M Ocio, Anna Maria Sureda Balari, Felipe De Arriba, Miguel Teodoro Hernández Garcia, Antonio Garcia, Joaquin Martinez-Lopez, María-Jesús Blanchard, Marta Sonia Gonzalez Perez, Rebeca Iglesias, Alberto Orfao, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Joan Bladé, Jesus San-Miguel, María T Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 871.
https://doi.org/10.1182/blood-2023-185661
Published: 2023
Journal Articles

Efficacy and Safety of Less Frequent/Lower Intensity Dosing of Talquetamab in Patients with Relapsed/Refractory Multiple Myeloma: Results from the Phase 1/2 MonumenTAL-1 Study

Ajai Chari, Albert Oriol, Amrita Krishnan, Maria Del Carmen Martinez Chamorro, Luciano Costa, Maria Victoria Mateos, Monique C Minnema, Michela Campagna, Tara J Masterson, Brandi W Hilder, Jaszianne Tolbert, Thomas Renaud, M. Damiette Smit, Swarna Ramanjulu, Paula Rodríguez Otero
Journal: Blood
Blood (2023) 142 (Supplement 1): 1010.
https://doi.org/10.1182/blood-2023-181228
Published: 2023
Journal Articles

Clinical Outcomes of Subsequent Therapies in Patients with Relapsed/Refractory Multiple Myeloma Following Talquetamab Treatment: Analyses from the Phase 1/2 MonumenTAL-1 Study

Larysa Sanchez, Carolina Schinke, Amrita Krishnan, Jésus G Berdeja, Niels WCJ van de Donk, María Victoria Mateos, Ajai Chari, Samir Parekh, Tarek H. Mouhieddine, Sundar Jagannath, Nizar J Bahlis, Cyrille Touzeau, Albert Oriol, Jesus San-Miguel, Paula Rodriguez Otero, Monique C Minnema, Michela Campagna, Tara J Masterson, Brandi W Hilder, Jaszianne Tolbert, Thomas Renaud, Kathleen Gray, Damiette Smit, Christoph Heuck, Leo Rasche
Journal: Blood
Blood (2023) 142 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2023-182330
Published: 2023