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Journal Articles

Predictors of unsustained measurable residual disease negativity in patients with multiple myeloma

Clinical Trials & Observations Brief Report
Mattia D’Agostino, Giuseppe Bertuglia, Delia Rota-Scalabrini, Angelo Belotti, Sonia Morè, Paolo Corradini, Stefania Oliva, Antonio Ledda, Mariella Grasso, Vincenzo Pavone, Sonia Ronconi, Iolanda Donatella Vincelli, Stelvio Ballanti, Cristina Velluti, Claudia Cellini, Alessandro Gozzetti, Angelo D. Palmas, Barbara Gamberi, Katia Mancuso, Laura Paris, Renato Zambello, Maria Teresa Petrucci, Benedetto Bruno, Pellegrino Musto, Francesca Gay
Journal: Blood
Blood (2024) 143 (7): 592–596.
https://doi.org/10.1182/blood.2023022080
Published: 2024
Includes: Supplemental data
Journal Articles

Iberdomide Maintenance after Autologous Stem-Cell Transplantation in Newly Diagnosed MM: First Results of the Phase 2 EMN26 Study

Niels W.C.J. van de Donk, Cyrille Touzeau, Evangelos Terpos, Aurore Perrot, Roberto Mina, Maaike de Ruijter, Elisabetta Antonioli, Eirini Katodritou, Norbert Pescosta, Paulus A.F. Geerts, Cécile Sonntag, Ruth Wester, Angelo Belotti, Silvia Mangiacavalli, Massimo Offidani, Mattia D'Agostino, Mark van Duin, Michele Cavo, Sara Aquino, Alessandra Lombardo, Mark-David Levin, Cyrille Hulin, Mario Boccadoro, Pieter Sonneveld, Francesca Gay
Journal: Blood
Blood (2023) 142 (Supplement 1): 208.
https://doi.org/10.1182/blood-2023-177564
Published: 2023
Journal Articles

Genomic and Immune Determinants of Resistance to Anti-CD38 MoAb Based Therapy in Relapsed Multiple Myeloma

Bachisio Ziccheddu, Claudia Giannotta, Mattia D'Agostino, Giuseppe Bertuglia, Elona Saraci, Stefania Oliva, Benjamin Diamond, Niccolò Bolli, Paolo Corradini, David Coffey, Ola Landgren, Benedetto Bruno, Mario Boccadoro, Massimo Massaia, Francesco Maura, Alessandra Larocca
Journal: Blood
Blood (2023) 142 (Supplement 1): 1966.
https://doi.org/10.1182/blood-2023-182301
Published: 2023
Journal Articles

Results of the Phase III Randomized Iskia Trial: Isatuximab-Carfilzomib-Lenalidomide-Dexamethasone Vs Carfilzomib-Lenalidomide-Dexamethasone As Pre-Transplant Induction and Post-Transplant Consolidation in Newly Diagnosed Multiple Myeloma Patients

Francesca Gay, Wilfried Roeloffzen, Meletios A. Dimopoulos, Laura Rosiñol, Marjolein van der Klift, Roberto Mina, Albert Oriol Rocafiguera, Eirini Katodritou, Ka Lung Wu, Paula Rodriguez Otero, Roman Hajek, Elisabetta Antonioli, Mark van Duin, Mattia D'Agostino, Joaquin Martinez-Lopez, Elena M. van Leeuwen-Segarceanu, Paola Tacchetti, Niels W.C.J. van de Donk, Katja Weisel, Luděk Pour, Jakub Radocha, Angelo Belotti, Fredrik Schjesvold, Joan Bladé, Hermann Einsele, Pieter Sonneveld, Mario Boccadoro, Annemiek Broijl
Journal: Blood
Blood (2023) 142 (Supplement 1): 4.
https://doi.org/10.1182/blood-2023-177546
Published: 2023
Journal Articles

Carfilzomib-Lenalidomide-Dexamethasone (KRd) Vs. Lenalidomide-Dexamethasone (Rd) in Newly Diagnosed Fit or Intermediate-Fit Multiple Myeloma Patients Not Eligible for Autologous Stem-Cell Transplantation (Phase III EMN20 Trial): Analysis of Sustained Undetectable Minimal Residual Disease (MRD)

Sara Bringhen, Elisabetta Antonioli, Barbara Gamberi, Benedetto Bruno, Daniele Derudas, Patrizia Tosi, Francesca Fazio, Rita Mazza, Sonia Ronconi, Paolo Corradini, Flavia Lotti, Claudia Cellini, Antonietta Pia Falcone, Piero Galieni, Roberto Ria, Angelo Belotti, Donato Mannina, Anna Maria Cafro, Clotilde Cangialosi, Iolanda Donatella Vincelli, Alessandra Lombardo, Alessandra Larocca, Mario Boccadoro, Mattia D'Agostino
Journal: Blood
Blood (2023) 142 (Supplement 1): 205.
https://doi.org/10.1182/blood-2023-177673
Published: 2023
Journal Articles

Impact of Daratumumab on Hematopoietic Stem Cell Mobilization with G-CSF and on-Demand Plerixafor in Newly-Diagnosed Multiple Myeloma Patients

Roberto Mina, Bruno Garibaldi, Giuseppe Bertuglia, Andrea Casson, Barbara Sarina, Francesca Gay, Silvio Mercadante, Jacopo Mariotti, Mattia D'Agostino, Daniela Taurino, Stefania Oliva, Alessandra Larocca, Daniele Mannina, Chiara De Philippis, Giulia Benevolo, Tiziana Francisci, Marco Lorenzi, Benedetto Bruno, Armando Santoro, Sara Bringhen, Stefania Bramanti
Journal: Blood
Blood (2023) 142 (Supplement 1): 6633.
https://doi.org/10.1182/blood-2023-180082
Published: 2023
Journal Articles

Bortezomib-Melphalan-Prednisone (VMP) Vs. Lenalidomide-Dexamethasone (Rd) in Transplant-Ineligible Real-Life Multiple Myeloma Patients: Updated Results of the Randomized Phase IV Real MM Trial

Sara Bringhen, Mattia D'Agostino, Nicola Giuliani, Irene Attucci, Renato Zambello, Sonia Ronconi, Iolanda Donatella Vincelli, Alessandro Allegra, Giovanna Leonardi, Giuseppe Rossi, Francesco Cattel, Andrea Capra, Piero Galieni, Alessandra Lombardo, Francesca Bonello, Patrizia Tosi, Maide Maria Cavalli, Elisa Sciorsi, Donato Mannina, Roberto Ria, Francesca Patriarca, Michele Cavo, Silvia Mangiacavalli, Giulia Benevolo, Andrea Evangelista, Mario Boccadoro, Benedetto Bruno, Alessandra Larocca
Journal: Blood
Blood (2022) 140 (Supplement 1): 1814–1816.
https://doi.org/10.1182/blood-2022-162178
Published: 2022
Journal Articles

Dedalo: Phase II Study of Daratumumab Plus Pomalidomide and Dexamethasone (DPd) in Patients with Relapsed/Refractory Multiple Myeloma and 17p Deletion

Vittorio Montefusco, Anna Maria Cafro, Gloria Margiotta Casaluci, Francesca Patriarca, Roberto Mina, Mattia D'Agostino, Andrea Capra, Claudia Priola, Anna Benedetta Dalla Palma, Rita Rizzi, Angelo Genua, Maria Teresa Petrucci, Laura Paris, Angelo Belotti, Michele Cavo, Concetta Conticello, Carmelo Carlo-Stella, Mario Boccadoro
Journal: Blood
Blood (2022) 140 (Supplement 1): 10193–10195.
https://doi.org/10.1182/blood-2022-156691
Published: 2022
Journal Articles

Combining Plasma Cell Leukemia-like Status with the Second Revision of the International Staging System Improves Risk Classification

Davine Hofste op Bruinink, Rowan Kuiper, Mark van Duin, Tom Cupedo, Vincent H.J. van der Velden, Remco Hoogenboezem, Bronno van der Holt, Berna Beverloo, Erik T. Valent, Michael Vermeulen, Mattia D'Agostino, Francesca Gay, Annemiek Broijl, Herve Avet-Loiseau, Nikhil C Munshi, Pellegrino Musto, Philippe Moreau, Sonja Zweegman, Niels W.C.J. van de Donk, Pieter Sonneveld
Journal: Blood
Blood (2022) 140 (Supplement 1): 1566–1567.
https://doi.org/10.1182/blood-2022-170249
Published: 2022
Journal Articles

Single-Cell Transcriptomic Analysis Reveals Reduction of Cytotoxic NK Cells in a Subset of Newly Diagnosed Multiple Myeloma Patients Impacting Outcome after Daratumumab Therapy

Sabrin Tahri, Madelon M.E. de Jong, Cathelijne Fokkema, Natalie Papazian, Zoltan Kellermayer, Michael Vermeulen, Mark van Duin, Pieter van de Woestijne, Kazem Nasserinejad, Elona Saraci, Mattia D'Agostino, Francesca Gay, Vincent H.J. van der Velden, Niels WCJ Van De Donk, Annemiek Broijl, Pieter Sonneveld, Sonja Zweegman, Tom Cupedo
Journal: Blood
Blood (2022) 140 (Supplement 1): 9982–9984.
https://doi.org/10.1182/blood-2022-164812
Published: 2022
Journal Articles

Dose/schedule-adjusted Rd-R vs continuous Rd for elderly, intermediate-fit patients with newly diagnosed multiple myeloma

Clinical Trials & Observations
Alessandra Larocca, Francesca Bonello, Gianluca Gaidano, Mattia D’Agostino, Massimo Offidani, Nicola Cascavilla, Andrea Capra, Giulia Benevolo, Patrizia Tosi, Monica Galli, Roberto Marasca, Nicola Giuliani, Annalisa Bernardini, Elisabetta Antonioli, Delia Rota-Scalabrini, Claudia Cellini, Alessandra Pompa, Federico Monaco, Francesca Patriarca, Tommaso Caravita di Toritto, Paolo Corradini, Paola Tacchetti, Mario Boccadoro, Sara Bringhen
Journal: Blood
Blood (2021) 137 (22): 3027–3036.
https://doi.org/10.1182/blood.2020009507
Published: 2021
Includes: Supplemental data
Journal Articles

Impact of Imaging FDG-PET/CT Minimal Residual Disease Assessment on Outcomes and Matching with Bone Marrow Techniques in Newly Diagnosed Transplant Eligible Multiple Myeloma (MM) Patients: Results of the Phase II Randomized Forte Trial

Elena Zamagni, Cristina Nanni, MD, Francesca Gay, MD, Luca Dozza, MSc, Delia Rota Scalabrini, Mattia D'Agostino, MD, Rossella Ribolla, MD, Monica Galli, Manuela Racca, MD, Renato Zambello, Elena Rivolti, MD, Domenico Albano, MD, Annibale Versari, MD, Mariella Grasso, Rossella Troia, PharmD, Antonio Spadano, Francesca Patriarca, Marina Ruggeri, Marco Rensi, MD, Anna Pascarella, Pietro Zucchetta, MD, Paola Tacchetti, Stefano Fanti, MD PhD, Mario Boccadoro, Michele Cavo, Pellegrino Musto, Stefania Oliva
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-137412
Published: 2020
Journal Articles

Impact of Minimal Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC) and Next-Generation Sequencing (NGS) on Outcome: Results of Newly Diagnosed Transplant-Eligible Multiple Myeloma (MM) Patients Enrolled in the Forte Trial

Stefania Oliva, Elisa Genuardi, Maria Teresa Petrucci, Mattia D'Agostino, MD, Daniel Auclair, Antonio Spadano, Allison P. Jacob, Michele Cea, Luca De Rosa, Alessandro Gozzetti, Marina Ruggeri, Andrea Capra, Milena Gilestro, Norbert Pescosta, Angelo D. Palmas, Agostina Siniscalchi, Ilan R. Kirsch, Paolo Corradini, Pellegrino Musto, Mario Boccadoro, Elena Zamagni, Francesca Gay, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-137351
Published: 2020
Journal Articles

Revealing Transcriptome Deregulation upon Genomic Complexity in Multiple Myeloma

Matteo Claudio Da Via', MD, Bachisio Ziccheddu, Matteo Dugo, Marta Lionetti, PhD, Katia Todoerti, PhD, Mattia D'Agostino, MD, Antonino Neri, MD, Luca Baldini, MD PhD, Paolo Corradini, Francesco Maura, MD, Niccolo Bolli, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-136211
Published: 2020
Journal Articles

Poor Prognosis of Multiple Myeloma Predicted By High Levels of Circulating Plasma Cells Is Independent from Other High-Risk Features but Is Modulated By the Achievement of Minimal Residual Disease Negativity

Luca Bertamini, MD, Mariella Grasso, Mattia D'Agostino, MD, Anna Pascarella, Patrizia Tosi, Federico Monaco, Francesco Pisani, Paola Bertazzoni, Milena Gilestro, Andrea Capra, Piero Galieni, Ombretta Annibali, Vincenzo Pavone, Stefano Molica, MD, Sonia Ronconi, Paola Tacchetti, Pellegrino Musto, Francesca Gay, MD, Mario Boccadoro, Stefania Oliva
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-137075
Published: 2020
Journal Articles

Survival Analysis of Newly Diagnosed Transplant-Eligible Multiple Myeloma Patients in the Randomized Forte Trial

Francesca Gay, MD, Pellegrino Musto, Delia Rota Scalabrini, Monica Galli, Angelo Belotti, Elena Zamagni, Luca Bertamini, MD, Renato Zambello, Micol Quaresima, Giovanni De Sabbata, Giuseppe Pietrantuono, Mattia D'Agostino, MD, Daniela Oddolo, Andrea Capra, Anna Marina Liberati, Salvatore Palmieri, Franco Narni, Massimo Offidani, Michele Cavo, Mario Boccadoro
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–37.
https://doi.org/10.1182/blood-2020-136907
Published: 2020
Journal Articles

A New Risk Stratification Model (R2-ISS) in Newly Diagnosed Multiple Myeloma: Analysis of Mature Data from 7077 Patients Collected By European Myeloma Network within Harmony Big Data Platform

Mattia D'Agostino, MD, Juan-José Lahuerta, MD PhD, Ruth Wester, MD, Anders Waage, MD PhD, Uta Bertsch, Elena Zamagni, Maria-Victoria Mateos, MD PhD, Alessandra Larocca, Daniele Dall'Olio, Niels W. C. J. van de Donk, David Cairns, MSc, PhD, Serena Rocchi, Hans Salwender, MD, Joan Blade Creixenti, Bronno van der Holt, PhD, Castellani Gastone, Giovannino Ciccone, Andrea Capra, Jan Dürig, MD, Sara Bringhen, MD, Sonja Zweegman, MDPhD, Michele Cavo, Hartmut Goldschmidt, MD, Gordon Cook, MB ChB, PhD, Jesus Maria Hernández-Rivas, MD PhD, Jesus F. San-Miguel, MD PhD, Mario Boccadoro, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–37.
https://doi.org/10.1182/blood-2020-137021
Published: 2020
Journal Articles

Impact of Gain and Amplification of 1q in Newly Diagnosed Multiple Myeloma Patients Receiving Carfilzomib-Based Treatment in the Forte Trial

Mattia D'Agostino, MD, Marina Ruggeri, Sara Aquino, Nicola Giuliani, Maddalena Arigoni, Massimo Gentile, Martina Olivero, Iolanda Donatella Vincelli, Andrea Capra, Chiara Mussatto, Antonio Ledda, Paola Tacchetti, Caterina Musolino, Claudia Cellini, Francesca Patriarca, Stelvio Ballanti, Raffaele Calogero, Pellegrino Musto, Mario Boccadoro, Francesca Gay, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–40.
https://doi.org/10.1182/blood-2020-137060
Published: 2020
Journal Articles

Risk of Early Severe Infections in Newly Diagnosed Multiple Myeloma Patients Treated with Novel Agents: A Pooled Analysis

Francesca Bonello, Mattia D'Agostino, MD, Massimo Offidani, Maria Teresa Petrucci, Anna Marina Liberati, Francesca Patriarca, Andrea Capra, Giulia Benevolo, Gianluca Gaidano, Gregorio Barilà, Monica Galli, Elena Ponticelli, Nicola Cascavilla, Emanuele Angelucci, Stelvio Ballanti, Giuseppe Pietrantuono, Stefano Pulini, Daniele Derudas, Paolo de Fabritiis, Paolo Corradini, Concetta Conticello, Michele Cavo, Pieter Sonneveld, MD PhD, Mario Boccadoro, Sara Bringhen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-136302
Published: 2020
Journal Articles

Validation and Improvement Opportunities of the Revised International Staging System for Multiple Myeloma: An Analysis on Mature Data from European Clinical Trials within the Harmony Big Data Platform

Mattia D'Agostino, MD, Anders Waage, MD PhD, Juan-José Lahuerta, MD PhD, Uta Bertsch, Elena Zamagni, MD, Lars Bullinger, Alessandra Larocca, Maria-Victoria Mateos, Niels W. C. J. Van De Donk, Hans Jürgen Salwender, MD, Joan Bladé, MD, Bronno van der Holt, PhD, Paola Tacchetti, Giovannino Ciccone, Sonja Zweegman, Hartmut Goldschmidt, Michele Cavo, Jesús San-Miguel, Pieter Sonneveld, Mario Boccadoro, Jesús María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1773.
https://doi.org/10.1182/blood-2019-124321
Published: 2019