1-20 of 50
Christoph Driessen
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Regulation of BCMA By the Ubiquitin Proteasome System Enables Optimization of BCMA-Targeting Therapies in Multiple Myeloma

Leonie Rieger, Kilian Irlinger, Franziska Fuechsl, Nicolas Barbian, Marlene Tietje, Melanie Faber, Tobias Schulze, Piero Giansanti, Lenka Besse, Christoph Driessen, Angela Krackhardt, Bernhard Kuster, Florian Bassermann
Journal: Blood
Blood (2023) 142 (Supplement 1): 3310.
https://doi.org/10.1182/blood-2023-187349
Published: 2023
Journal Articles

A National Platform and Scoring System Allocates CAR-T Treatment Slots for Multiple Myeloma to Patients with High Likelihood of Complete Remission

Christoph Driessen, Katharina Baur, Dominik Heim, Sabine Gerull, Christoph Renner, Anne Cairoli, Thomas Pabst, Joerg Halter, Michael Gregor, Nicole Graf, Nino Fejzibegovic, Nathan Wolfensberger, Federico Simonetta, Martin Fehr, Esteban Ciliberti, Rouven Müller, Barbara Jeker
Journal: Blood
Blood (2023) 142 (Supplement 1): 4701.
https://doi.org/10.1182/blood-2023-182628
Published: 2023
Journal Articles

Targeting IGF1R/Insr Pathway with Approved ALK-Inhibitors Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma

Max Alberto Mendez-Lopez, Andrej Besse, Tiberiu Totu, Marianne Kraus, Anthonius P.A. Janssen, Marija Buljan, Mario Van Der Stelt, Lenka Besse, Christoph Driessen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4663.
https://doi.org/10.1182/blood-2023-177912
Published: 2023
Journal Articles

Impact of ABCB1 Promoter Methylation on PI-Resistance in Multiple Myeloma

Seungbin Han, Larissa Haertle, Lenka Besse, Chien-Yun Lee, Xiang Zhou, Umair Munawar, Andrej Besse, Miriam Kull, Max Bittrich, Max Johannes Steinhardt, Julia Mersi, Eva Teufel, Silvia Nerreter, Cornelia Vogt, Sophia Danhof, Jan Krönke, Niels Weinhold, Marc S Raab, Thomas Haaf, Christoph Driessen, Hermann Einsele, Leo Rasche, Bernhard Küster, Martin Kortuem
Journal: Blood
Blood (2022) 140 (Supplement 1): 12462–12463.
https://doi.org/10.1182/blood-2022-168694
Published: 2022
Journal Articles

MajesTEC-4 (EMN30): A Phase 3 Trial of Teclistamab + Lenalidomide Versus Lenalidomide Alone As Maintenance Therapy Following Autologous Stem Cell Transplantation in Patients with Newly Diagnosed Multiple Myeloma

Elena Zamagni, Mario Boccadoro, Andrew Spencer, Michel Delforge, Donna E. Reece, Agoston Gyula Szabo, Hermann Einsele, Evangelos Terpos, Fredrik Schjesvold, Jelena Bila, Christoph Driessen, Meral Beksac, Gordon Cook, Cesar Rodriguez, Lixia Pei, Yingqi Shi, Caline Sakabedoyan, Jagaoda Jasielec, Himal Amin, Rachel Kobos, Pieter Sonneveld, Niels WCJ Van De Donk
Journal: Blood
Blood (2022) 140 (Supplement 1): 7289–7291.
https://doi.org/10.1182/blood-2022-159756
Published: 2022
Journal Articles

Bortezomib Resistant Multiple Myeloma Shows a Specific Dependency on Ecpas in Vitro and In Vivo

Lenka Besse, Andrej Besse, Sara C. Stolze, Amin Sobh, Marianne Kraus, Hirofumi Nakagami, Christoph Driessen
Journal: Blood
Blood (2022) 140 (Supplement 1): 4183–4184.
https://doi.org/10.1182/blood-2022-167648
Published: 2022
Journal Articles

The Molecular Landscape and Essential Pathways Involved in Bone Marrow-Mediated Carfilzomib Resistance of Multiple Myeloma

Jonas Schwestermann, Andrej Besse, Serena Fazio, Cesar Nombela-Arrieta, Lenka Besse, Christoph Driessen
Journal: Blood
Blood (2022) 140 (Supplement 1): 4228–4229.
https://doi.org/10.1182/blood-2022-169024
Published: 2022
Journal Articles

Blocking the Don't Eat Me Signal (CD47-SIRPα Axis) to Improve Antibody-Based Immunotherapy of Multiple Myeloma

Katja Klausz, Carina Lynn Gehlert, Ammelie Svea Boje, Marta Lustig, Steffen Krohn, Syeda Maliha Ahmed, Christian Kellner, Thomas Valerius, Lenka Besse, Andrej Besse, Christoph Driessen, Martin Gramatzki, Matthias Peipp
Journal: Blood
Blood (2021) 138 (Supplement 1): 2684.
https://doi.org/10.1182/blood-2021-152208
Published: 2021
Journal Articles

High-Dose Carfilzomib Recaptures Response in Relapsed/Refractory Multiple Myeloma Resistant to Low-Dose Carfilzomib By Co-Inhibiting β2 Subunit of Proteasome Complex: The First in Human Evidence

Xiang Zhou, Andrej Besse, Jessica Peter, Max Mendez Lopez, Larissa Haertle, Umair Munawar, Seungbin Han, Elmer Maurits, Herman S. Overkleeft, Hermann Einsele, Christoph Driessen, Martin Kortuem, Lenka Besse, Leo Rasche
Journal: Blood
Blood (2021) 138 (Supplement 1): 818.
https://doi.org/10.1182/blood-2021-147170
Published: 2021
Journal Articles

Essential Drug Targets and Pathways in PI-Resistant MM Cells

Andrej Besse, Lenka Besse, Lorina Büchler, Sara C. Stolze, Amin Sobh, Marianne Kraus, Hirofumi Nakagami, Christoph Driessen
Journal: Blood
Blood (2021) 138 (Supplement 1): 1577.
https://doi.org/10.1182/blood-2021-150117
Published: 2021
Journal Articles

The Molecular Landscape and Essential Pathways Involved in Bone Marrow-Mediated Carfilzomib Resistance of Multiple Myeloma

Jonas Schwestermann, Andrej Besse, Lenka Besse, Christoph Driessen
Journal: Blood
Blood (2021) 138 (Supplement 1): 1571.
https://doi.org/10.1182/blood-2021-148395
Published: 2021
Journal Articles

Upfront Autologous Hematopoietic Stem-Cell Transplantation Improves Overall Survival in Comparison with Bortezomib-Based Intensification Therapy in Newly Diagnosed Multiple Myeloma: Long-Term Follow-up Analysis of the Randomized Phase 3 EMN02/HO95 Study

Michele Cavo, Francesca Gay, MD, Meral Beksac, MD, Meletios A Dimopoulos, Lucia Pantani, MD PhD, Maria Teresa Petrucci, Luca Dozza, MSc, Bronno Van Der Holt, PhD, Sonja Zweegman, MDPhD, Elena Zamagni, Giuseppe A. Palumbo, MD PhD, Francesca Patriarca, Monica Galli, Vladimir Maisnar, MD PhD MBA, Markus Hansson, MD, Angelo Belotti, Ludek Pour, MD, Paula F Ypma, MD PhD, Mariella Grasso, Sandra Croockewit, MD, Massimo Offidani, Renato Zambello, Anna Marina Liberati, MD, Niels Frost Andersen, MD PhD, Annemiek Broyl, MD PhD, Rossella Troia, PharmD, Pellegrino Musto, Heinz Ludwig, MD, Anna Maria Morelli, MD, Roman Hajek, MD, Christoph Driessen, MD, Anders Waage, MD PhD, Peter Gimsing, DO, PhD, Ulf-Henrik Mellqvist, MD PhD, Thilo Zander, MD, Mario Boccadoro, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137575
Published: 2020
Journal Articles

All-Trans-Retinoic Acid Prevents Carfilzomib-Induced Cardiotoxicity By Decreasing Activation of the Renin-Angiotensin System

Max A Mendez, Andrej Besse, Bogdan I. Florea, Christian Zuppinger, Herman S. Overkleeft, Lenka Besse, Christoph Driessen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19–20.
https://doi.org/10.1182/blood-2020-139277
Published: 2020
Journal Articles

Consolidation Treatment with VRD Followed By Maintenance Therapy Versus Maintenance Alone in Newly Diagnosed, Transplant-Eligible Patients with Multiple Myeloma (MM): A Randomized Phase 3 Trial of the European Myeloma Network (EMN02/HO95)

Pieter Sonneveld, MD PhD, Meral Beksac, MD, Bronno Van Der Holt, PhD, Meletios A Dimopoulos, Angelo Michele Carella, MD, Heinz Ludwig, MD, Sonja Zweegman, MD PhD, Thilo Zander, MD, Ruth Wester, MD, Roman Hajek, MD, Lucia Pantani, MD PhD, Luca Dozza, MSc, Francesca Gay, MD, Anna Maria Cafro, Luca De Rosa, Francesca Fioritoni, MD, Ulf-Henrik Mellqvist, MD PhD, Rossella Troia, PharmD, Niels Frost Andersen, MD PhD, Ka Lung Wu, MD PhD, Christoph Driessen, MD, Susana Carvalho, MD, Alexandra J. Croockewit, MD PhD, Fredrik Schjesvold, MDPhD, Massimo Offidani, Michele Cavo, Mario Boccadoro
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–48.
https://doi.org/10.1182/blood-2020-139337
Published: 2020
Journal Articles

Effect of ABCB1 Multidrug Resistance Protein on Efficacy of Anti-Myeloma Drugs in Carfilzomib-Resistant Myeloma Model

Konstantin Byrgazov, PhD, Marianne Kraus, Andrej Besse, Ana Slipicevic, Fredrik Lehmann, Christoph Driessen, MD, Lenka Besse
Journal: Blood
Blood (2020) 136 (Supplement 1): 36–37.
https://doi.org/10.1182/blood-2020-136725
Published: 2020
Journal Articles

Nelfinavir Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma By Modulating Membrane Lipid Bilayer Composition and Fluidity

Andrej Besse, Lenka Besse, Sara C. Stolze, Amin Sobh, PhD, Esther A. Zaal, Alwin J van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I. Florea, Jan Borén, Marcus Ståhlman, Alex Loguinov, Bart Everts, Celia R. Berkers, Marc Pilon, Hesso Farhan, Chris D. Vulpe, Herman S. Overkleeft, Christoph Driessen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-136253
Published: 2020
Journal Articles

Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology

Ian Ferguson, BA, Yu-Hsiu T. Lin, BA, Sami Tuomivaara, PhD, Jeffrey L. Wolf, MD, Thomas G. Martin, III, MD, Sandy W. Wong, MD, Nina D. Shah, MD, Christoph Driessen, MD, Brian G. Van Ness, PhD, Arun P. Wiita, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1803.
https://doi.org/10.1182/blood-2019-131681
Published: 2019
Journal Articles

Carfilzomib Induces Cardiotoxicity Via ß5/ß2-Specific Proteasome Subunit Inhibition Pattern

Max A Mendez-Lopez, MD, Andrej Besse, PhD, Bogdan Florea, PhD, Christian Zuppinger, PhD, Herman Overkleeft, PhD, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3110.
https://doi.org/10.1182/blood-2019-127987
Published: 2019
Journal Articles

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Andrej Besse, M.Sc, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD, Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Neha G Gupta, M.Sc., Abha Kushwaha, M.Sc., Pallavi Kumari, M.Sc., Karthik Sundara Raju, M.Sc., Ganesh Naga, B.Tech, Sayani Basu, M.Tech, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3193.
https://doi.org/10.1182/blood-2018-99-116939
Published: 2018
Journal Articles

Differential Effect of Upfront Intensification Treatment in Genetically Defined Myeloma Risk Groups - a Combined Analysis of ISS, Del17p and SKY92 Scores in the EMN-02/HOVON-95 MM Trial

Davine Hofste op Bruinink, MD MSc, Mark van Duin, PhD, Meral Beksac, MD, Christoph Driessen, MD, Heinz Ludwig, MD, Michael Vermeulen, BSc, Rowan Kuiper, MSc, Martin H van Vliet, PhD, Bronno van der Holt, PhD, Roman Hajek, MD PhD, Hans Erik Johnsen, MD Professor, Meletios A Dimopoulos, MD, Antonio Palumbo, MD, Michele Cavo, MD, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3186.
https://doi.org/10.1182/blood-2018-99-119873
Published: 2018