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Journal Articles

Feasibility and efficacy of daratumumab-vcd in transplant-ineligible elderly patients with newly diagnosed multiple myeloma: First results from the multicenter GMMG-dada study

Blood (2025) 146 (Supplement 1): 4050.

https://doi.org/10.1182/blood-2025-4050

Published: 2025

Journal Articles

Adipose tissue-associated lipid serum signatures modulate efficacy and toxicity of CAR-T cell therapy in lymphoid malignancies

David Cordas Dos Santos, Hannah Thurisch, Jingke Tu, Daniel Heilpern-Mallory, Amar Hadzic, Martin Kirmaier, Werner Schmitz, Martin Vaeth, Sabine Oganesian, Adriano Carboniero, Ludovica Vona, Viktoria Blumenberg, Veit Buecklein, Michael Von Bergwelt, Kai Rejeski, Marion Subklewe, Sebastian Theurich

Blood (2025) 146 (Supplement 1): 5887.

https://doi.org/10.1182/blood-2025-5887

Published: 2025

Journal Articles

Pre-treatment vaccine seroprotection is markedly lower in BCMA-CAR vs CD19-CAR recipients with limited post-therapy modulation

Giulia Magno, Elif Apak, Savanna Süß, Giulia Rappa, Patricia M. Späth, Sophia Stock, Alessandra Holzem, Wajma Shahbaz, Tobias Tix, Bernhard Ismann, Judith S. Hecker, Florian Bassermann, Sebastian Theurich, Michael Von Bergwelt, Kai Rejeski, Oliver T. Keppler, Marion Subklewe, Veit Buecklein

Blood (2025) 146 (Supplement 1): 6355.

https://doi.org/10.1182/blood-2025-6355

Published: 2025

Journal Articles

Beyond ECOG: Assessment of physical function enhances risk stratification prior to CAR-T cell therapy

Alessandra Holzem, Michael Ingrisch, Anna Magee, Veronika Kezzo, Tobias Tix, Sophia Stock, Giulia Magno, Wajma Shahbaz, Michaela Braxenthaler, Michael Von Bergwelt, Wolfgang Kunz, Veit Buecklein, Sebastian Theurich, Marion Subklewe, Kai Rejeski

Blood (2025) 146 (Supplement 1): 6331.

https://doi.org/10.1182/blood-2025-6331

Published: 2025

Journal Articles

Multi-faceted influence of immunomodulatory metabolites on CAR-T cell therapy

Dhyani Shah, Markus Perl, Matthias Fante, Severin Guetter, Simon Holzinger, Luisa-Marie Becker, Misbah Tariq, Philipp Meanauer, Simon Delahais, Gloria Lutzny-Geier, Julian Scherer, Sascha Goettert, Konstantin Herfeld, Paul Heinrich, Klaus-Georg Kreitmeier, Wolfgang Herr, Janina Doerr, Dennis Harrer, Leo Hansmann, Marcel Trefny, Matthias Edinger, Daniel Wolff, Daniela Weber, Elisabeth Meedt, André Gessner, Ernst Holler, Tobias Wertheimer, Klaus Neuhaus, Tingting Zheng, Kai Ziegler-Martin, David M. Cordas Dos Santos, Sebastian Theurich, Melanie Schirmer, Jonas Schluter, Michael Schmitt, Karin Kleigrewe, Markus Feuerer, Christoph Heuser-Loy, Jeremy Baldwin, Michael Hudecek, Luca Gattinoni, Marion Subklewe, Viktoria Blumenberg, Maria-Luisa Schubert, Christoph Stein-Thoeringer, Maik Luu, Sebastian Kobold, Erik Thiele Orberg, Hendrik Poeck

Blood (2025) 146 (Supplement 1): 2343.

https://doi.org/10.1182/blood-2025-2343

Published: 2025

Journal Articles

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

Blood blood.2024027616.

https://doi.org/10.1182/blood.2024027616

Published: 2025

Includes: Supplemental data

Journal Articles

L-Asparaginase Treatment Induces Reversible Immunoregulatory and Immunosuppressive Effects in Non-Malignant B Cells in a Model of T-Cell Dependent B Cell Activation

Amar Hadzic, Maria Garcia-Marquez, David M. Cordas dos Santos, Martin E. Kirmaier, Pol Bannasch, Nina Haindl, Sabine Oganesian, Maximilian A Funk, Anneli Tischmacher, Katharina Frey, Ludovica Vona, Adriano Carboniero, Jingke Tu, Michael Von Bergwelt, Sebastian Theurich

Blood (2024) 144 (Supplement 1): 3918.

https://doi.org/10.1182/blood-2024-203127

Published: 2024

Journal Articles

Symptomatic Progression Free Survival (SPFS): A New Endpoint for Multiple Myeloma (MM) Combining Patient-Reported Outcomes (PROs) and Progression-Free Survival (PFS)

Martin K. Kortüm, Sebastian Theurich, James Farrell, Joseph C. Cappelleri, Olivia Ashman, Shanti Neff-Baro, Aline Gauthier, Khalil Jewiti-Rigondza, Christof Scheid

Blood (2024) 144 (Supplement 1): 3322.

https://doi.org/10.1182/blood-2024-204074

Published: 2024

Journal Articles

Pre-Apheresis Prediction of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Blood (2024) 144 (Supplement 1): 895.

https://doi.org/10.1182/blood-2024-208376

Published: 2024

Journal Articles

Distinct Temporal Dynamic Serum Metabolite Profiles Characterize Treatment Response and Early Toxicity after B-Cell Lymphoma Directed CAR-T-Cell Therapy

David M. Cordas dos Santos, Amar Hadzic, Martin E. Kirmaier, Werner Schmitz, Viktoria Blumenberg, Kai Rejeski, Veit L. Buecklein, Michael von Bergwelt-Baildon, Marion Subklewe, Sebastian Theurich

Blood (2023) 142 (Supplement 1): 2078.

https://doi.org/10.1182/blood-2023-186178

Published: 2023

Journal Articles

ZBTB7A Loss Promotes Synthesis of Lipids and Ketone Bodies in Myeloid Leukemia

Vanessa C. Arfelli, Werner Schmitz, Martin E. Kirmaier, Enric Redondo Monte, Paul Kerbs, Monica Cusan, Sebastian Theurich, Christian Wichmann, Philipp A. Greif

Blood (2023) 142 (Supplement 1): 1390.

https://doi.org/10.1182/blood-2023-185682

Published: 2023

Journal Articles

The CAR-Hematotox Score As a Prognostic Model of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Kai Rejeski, Doris K. Hansen, Radhika Bansal, Pierre Sesques, Sikander Ailawadhi, Jennifer M. Logue, Ciara L. Freeman, Melissa Alsina, Sebastian Theurich, Frederick L. Locke, Emmanuel Bachy, Michael D. Jain, Yi Lin, Marion Subklewe

Blood (2022) 140 (Supplement 1): 7506–7508.

https://doi.org/10.1182/blood-2022-165266

Published: 2022

Journal Articles

Body Composition and Immunonutritional Status Impact Survival Outcomes after CD19 CAR T-Cell Therapy

Kai Rejeski, David M. Cordas dos Santos, Paul Trinkner, Sophie Guenther, Lian Liu, Michael Winkelmann, Veit L Buecklein, Viktoria Blumenberg, Christian Schmidt, Philipp Karschnia, Wolfgang G. Kunz, Michael von Bergwelt, Sebastian Theurich, Marion Subklewe

Blood (2022) 140 (Supplement 1): 10405–10406.

https://doi.org/10.1182/blood-2022-159493

Published: 2022

Journal Articles

Density of the Spleen in Low-Dose CT Scans Is Associated with High-Risk Disease Features and Shorter Survival in Newly Diagnosed Multiple Myeloma Patients

David M. Cordas dos Santos, Paul Trinkner, Sophie Guenther, Michael Winkelmann, Wolfgang G. Kunz, Kai Rejeski, Marion Subklewe, Michael von Bergwelt, Sebastian Theurich

Blood (2022) 140 (Supplement 1): 4332–4333.

https://doi.org/10.1182/blood-2022-163091

Published: 2022

Journal Articles

Alterations of Human Bone Marrow Niche in Clonal Hematopoiesis and AML

Yana Dragieva, Maja Rothenberg-Thurley, Bianka Ksienzyk, Amar Hadzic, Alexander Paulus, Benjamin Tast, Maryam Kazerani, Marion Subklewe, Stephanie Schneider, Karsten Spiekermann, Sebastian Theurich, Klaus H. Metzeler, Maria Solovey, Frank Ziemann

Blood (2022) 140 (Supplement 1): 11430–11431.

https://doi.org/10.1182/blood-2022-167168

Published: 2022

Journal Articles

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Blood (2022) 140 (10): 1104–1118.

https://doi.org/10.1182/blood.2022015956

Published: 2022

Includes: Supplemental data

Journal Articles

CD33 BiTE ® Construct Mediated Immunological Synapse Formation and Downstream Signaling in T Cells Is Dependent on Expression of Costimulatory Molecules on Target Cells

Anetta Marcinek, Bettina Brauchle, Gerulf Hänel, Sonja M Lacher, Nora Zieger, Roman Kischel, Michael von Bergwelt, Karsten Spiekermann, Sebastian Theurich, John R James, Veit L Buecklein, Marion Subklewe

Blood (2021) 138 (Supplement 1): 2237.

https://doi.org/10.1182/blood-2021-146488

Published: 2021

Journal Articles

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Blood (2021) 138 (Supplement 1): 513.

https://doi.org/10.1182/blood-2021-150178

Published: 2021

Journal Articles

Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Nora Zieger, Alyssa Nicholls, Jan Wulf, Gerulf Hänel, Maryam Kazerani Pasikhani, Veit Buecklein, MD, Bettina Brauchle, Anetta Marcinek, Daniel Nixdorf, Lisa Rohrbacher, Michaela Scheurer, Roman Kischel, MD, Karsten Spiekermann, MD, Oliver Weigert, MD, Sebastian Theurich, MD, Michael von Bergwelt, MD PhD, Marion Subklewe, MD

Blood (2020) 136 (Supplement 1): 44–45.

https://doi.org/10.1182/blood-2020-137421

Published: 2020

Journal Articles

Loss of ZBTB7A Enhances Glycolysis and Beta Oxidation in Myeloid Leukemia

Enric Redondo Monte, MSc, BSc, Anja Wilding, MSc, Georg Leubolt, MSc, Paul Kerbs, MSc, Johannes Bagnoli, Wolfgang Hiddemann, MD PhD, Wolfgang Enard, PhD, Sebastian Theurich, MD, Philipp A. Greif, MD PD

Blood (2019) 134 (Supplement_1): 1453.

https://doi.org/10.1182/blood-2019-128378

Published: 2019

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Feasibility and efficacy of daratumumab-vcd in transplant-ineligible elderly patients with newly diagnosed multiple myeloma: First results from the multicenter GMMG-dada study

Adipose tissue-associated lipid serum signatures modulate efficacy and toxicity of CAR-T cell therapy in lymphoid malignancies

Pre-treatment vaccine seroprotection is markedly lower in BCMA-CAR vs CD19-CAR recipients with limited post-therapy modulation

Beyond ECOG: Assessment of physical function enhances risk stratification prior to CAR-T cell therapy

Multi-faceted influence of immunomodulatory metabolites on CAR-T cell therapy

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

L-Asparaginase Treatment Induces Reversible Immunoregulatory and Immunosuppressive Effects in Non-Malignant B Cells in a Model of T-Cell Dependent B Cell Activation

Symptomatic Progression Free Survival (SPFS): A New Endpoint for Multiple Myeloma (MM) Combining Patient-Reported Outcomes (PROs) and Progression-Free Survival (PFS)

Pre-Apheresis Prediction of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Distinct Temporal Dynamic Serum Metabolite Profiles Characterize Treatment Response and Early Toxicity after B-Cell Lymphoma Directed CAR-T-Cell Therapy

ZBTB7A Loss Promotes Synthesis of Lipids and Ketone Bodies in Myeloid Leukemia

The CAR-Hematotox Score As a Prognostic Model of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Body Composition and Immunonutritional Status Impact Survival Outcomes after CD19 CAR T-Cell Therapy

Density of the Spleen in Low-Dose CT Scans Is Associated with High-Risk Disease Features and Shorter Survival in Newly Diagnosed Multiple Myeloma Patients

Alterations of Human Bone Marrow Niche in Clonal Hematopoiesis and AML

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

CD33 BiTE ® Construct Mediated Immunological Synapse Formation and Downstream Signaling in T Cells Is Dependent on Expression of Costimulatory Molecules on Target Cells

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Loss of ZBTB7A Enhances Glycolysis and Beta Oxidation in Myeloid Leukemia

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