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Hendrik Poeck
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Journal Articles

The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut

Free
Alix Schwarz, Simon Holzinger, Peter Herhaus, Mareike Verbeek, Klaus Neuhaus, Karin Kleigrewe, Klaus-Peter Janssen, Matthias Edinger, Elisabeth Meedt, Daniel Wolff, Daniela Weber, Ernst Holler, Romana Gerner, Andreas Hiergeist, André Gessner, Peter Neumeister, Wolfgang Herr, Florian Bassermann, Walter Spindelboeck, Christoph Hoegnauer, Hendrik Poeck, Erik Thiele Orberg
Journal: Blood
Blood (2025) 146 (Supplement 1): 4236.
https://doi.org/10.1182/blood-2025-4236
Published: 2025
Journal Articles

Impact of IKZFplus status and ABL1 kinase domain mutations in patients with newly diagnosed Philadelphia-chromosome positive acute lymphoblastic leukemia receiving imatinib and chemotherapy followed by allogeneic SCT within GMALL07/03

Free
Heike Pfeifer, Maher Hanoun, Ahmet Elmaagacli, Simon Raffel, Boris Böll, Klaus Wethmar, Andreas Viardot, Björn Steffen, Sonja Martin, Veit Buecklein, Stefan Schwartz, Knut Wendelin, Hendrik Poeck, Doris Kraemer, Mathias Hänel, Lisa Heberling, Thomas Burmeister, Monika Brüggemann, Thomas Oellerich, Hubert Serve, Nicola Gökbuget, Fabian Lang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3373.
https://doi.org/10.1182/blood-2025-3373
Published: 2025
Journal Articles

Multi-faceted influence of immunomodulatory metabolites on CAR-T cell therapy

Free
Dhyani Shah, Markus Perl, Matthias Fante, Severin Guetter, Simon Holzinger, Luisa-Marie Becker, Misbah Tariq, Philipp Meanauer, Simon Delahais, Gloria Lutzny-Geier, Julian Scherer, Sascha Goettert, Konstantin Herfeld, Paul Heinrich, Klaus-Georg Kreitmeier, Wolfgang Herr, Janina Doerr, Dennis Harrer, Leo Hansmann, Marcel Trefny, Matthias Edinger, Daniel Wolff, Daniela Weber, Elisabeth Meedt, André Gessner, Ernst Holler, Tobias Wertheimer, Klaus Neuhaus, Tingting Zheng, Kai Ziegler-Martin, David M. Cordas Dos Santos, Sebastian Theurich, Melanie Schirmer, Jonas Schluter, Michael Schmitt, Karin Kleigrewe, Markus Feuerer, Christoph Heuser-Loy, Jeremy Baldwin, Michael Hudecek, Luca Gattinoni, Marion Subklewe, Viktoria Blumenberg, Maria-Luisa Schubert, Christoph Stein-Thoeringer, Maik Luu, Sebastian Kobold, Erik Thiele Orberg, Hendrik Poeck
Journal: Blood
Blood (2025) 146 (Supplement 1): 2343.
https://doi.org/10.1182/blood-2025-2343
Published: 2025
Journal Articles

Timed inhibition of the sting pathway improves tissue regeneration and prevents GVHD following allo-HSCT

Free
Sascha Göttert, Chiara Suriano, Omer Khalid, Paul Heinrich, Sakhila Ghimire, Eva Vonbrunn, Elisabeth Meedt, Petra Hoffmann, Matthias Edinger, Daniela Weber, Daniel Wolff, Michael Rehli, Maike Büttner-Herold, Wolfgang Herr, Ernst Holler, Christian Schmidl, Hendrik Poeck
Journal: Blood
Blood (2025) 146 (Supplement 1): 2317.
https://doi.org/10.1182/blood-2025-2317
Published: 2025
Journal Articles

Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation

Open Access
Ekin Ece Gurer Kluge, Elisabeth Meedt, Julia Feicht, Kedi Cao, Andreas Hiergeist, Andreas Mamilos, Daniela Hirsch, Matthias Hoepting, Dr. med, Anna-Sophia Kattner, Dr. med, Carina Matos, Sigrid Bülow, Erik Thiele Orberg, Philipp Beckhove, Arne Kandulski, Matthias Evert, Kai Hildner, Marina Kreutz, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Hendrik Poeck, André Gessner, Daniela Andrea Weber, Birte Kehr, Ernst Holler, Prof. Dr. med, Sakhila Ghimire
Journal: Blood
Blood blood.2025029402.
https://doi.org/10.1182/blood.2025029402
Published: 2025
Includes: Supplemental data
Journal Articles

Update on GMALL Trial 08/2013 Shows Durable Favorable Outcome of Newly Diagnosed Adult Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ALL) with Imatinib, Dose-Reduced Induction Followed By Stem Cell Transplantation

Free
Heike Pfeifer, Fabian Lang, Walter Fiedler, Matthias Stelljes, Folker Schneller, Björn Steffen, Boris Böll, Andreas Viardot, Christoph Faul, Lino L. Teichmann, Hendrik Poeck, Joerg Westermann, Kerstin Schäfer-Eckart, Thomas Heinicke, Thomas Burmeister, Stefan Schwartz, Monika Brueggemann, Hubert Serve, Nicola Goekbuget
Journal: Blood
Blood (2024) 144 (Supplement 1): 840.
https://doi.org/10.1182/blood-2024-201217
Published: 2024
Journal Articles

Recovery of the Intestinal Microbiome in Patients at Day +100 after Allogeneic Stem Cell Transplantation Is Defined By Microbial Metabolite Profiles and Linked to Long-Term Outcomes

Free
Alix Schwarz, Tina Eismann, Tingting Zheng, Sophia Goeldel, Mats Urban, Mohsen Pourjam, Klaus Neuhaus, Ilias Lagkouvardos, Daniel Wolff, Peter Herhaus, Mareike Verbeek, Ernst Holler, Wolfgang Herr, Karin Kleigrewe, Simon M Heidegger, Klaus-Peter Janssen, Florian Bassermann, Melanie Schirmer, Hendrik Poeck, Daniela Weber, Erik Thiele Orberg
Journal: Blood
Blood (2024) 144 (Supplement 1): 780.
https://doi.org/10.1182/blood-2024-199035
Published: 2024
Journal Articles

Immunomodulatory Microbial Metabolites Protect Against Graft-Vs-Host Disease and Enhance Anti-Leukemia Responses in Mice and Patients Receiving Stem Cell Transplantation

Free
Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Paul Heinrich, Daniel Wolff, Daniela Weber, Florian Bassermann, Petra Hoffmann, Matthias Edinger, Natalie Koehler, André Gessner, Wolfgang Herr, Simon M Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2024) 144 (Supplement 1): 264.
https://doi.org/10.1182/blood-2024-205921
Published: 2024
Journal Articles

Inflammation-Based Scores Predict Survival after CD3xCD20 Bispecific T Cell Engagers in R/R LBCL

Free
Giulia Magno, Kai Rejeski, Giulia Rappa, Sissi Kupf, Sophia Stock, Alessandra M. E. Holzem, Julia Katharina Scholz, Rebecca Wurm-Kuczera, Shimrit Harlev, Nadine Kutsch, Giuliano Filippini Velazquez, Stephanie Mayer, Maria Landwehr, Jamila Mammadova, Sandeep S. Raj, Roni Shouval, Fabian Mueller, Björn Chapuy, Ofrat Beyar-Katz, Udo Holtick, Christoph Schmidt, Hendrik Poeck, Gloria Iacoboni, Pere Barba, Ning Dong, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 1714.
https://doi.org/10.1182/blood-2024-211459
Published: 2024
Journal Articles

Loss of Microbiota-Derived Metabolites Is Associated with Mucosal-Barrier-Injury Bloodstream Infection in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Free
Sophia Göldel, Tingting Zheng, Tina Eismann, Melanie Tiefgraber, Mats Urban, Alix Schwarz, Klaus Neuhaus, Mohsen Pourjam, Ilias Lagkouvardos, Elisabeth Meedt, Karin Kleigrewe, Julia Frank, Michael Neuenhahn, Dirk H Busch, Peter Herhaus, Mareike Verbeek, Wolfgang Herr, Romana Gerner, Klaus-Peter Janssen, Simon M Heidegger, Florian Bassermann, Hendrik Poeck, Melanie Schirmer, Erik Thiele-Orberg
Journal: Blood
Blood (2024) 144 (Supplement 1): 4904.
https://doi.org/10.1182/blood-2024-193273
Published: 2024
Journal Articles

Tocilizumab Administration in CAR-T Cell Associated Cytokine Release Syndrome Induces Hypofibrinogenemia

Free
Markus Perl, Konstantin Herfeld, Dennis Harrer, Matthias Hoepting, Marina Schweiger, Ulrich Sterz, Leonard Knoedler, Leo Hansmann, Wolfgang Herr, Hendrik Poeck, Daniel Wolff, Matthias Edinger, Christina Hart, Matthias Fante
Journal: Blood
Blood (2023) 142 (Supplement 1): 5493.
https://doi.org/10.1182/blood-2023-186878
Published: 2023
Journal Articles

Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients

Free
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Alix Schwarz, Klaus-Peter Janssen, Peter Herhaus, Mareike Verbeek, Marcel R.M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2023) 142 (Supplement 1): 477.
https://doi.org/10.1182/blood-2023-172457
Published: 2023
Journal Articles

Identification of Bacterial and Viral Consortia for the Production of Intestinal Microbiota-Derived Metabolites Associated with Protection in Allogeneic Stem Cell Transplantation Patients

Free
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Karin Kleigrewe, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Christian Schulz, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk Busch, Wolfgang Herr, Florian Bassermann, Li Deng, Andre Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7619–7621.
https://doi.org/10.1182/blood-2022-157423
Published: 2022
Journal Articles

Effects of Bacterial Metabolites on CAR-T Cell Therapy

Free
Luisa Becker, Markus Perl, Leonard Knödler, Wolfgang Herr, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 12703.
https://doi.org/10.1182/blood-2022-169496
Published: 2022
Journal Articles

IFN-Gamma Is Crucial for the Counterbalance of T Cell-Mediated Injury to the Intestinal Stem Cell Compartment By Regulatory T Cells in Mice and Humans

Free
Sascha Göttert, Julius Clemens Fischer, Gabriel Eisenkolb, Erik Thiele Orberg, Sebastian Jarosch, Ernst Holler, Dirk Busch, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 10223–10224.
https://doi.org/10.1182/blood-2022-169303
Published: 2022
Journal Articles

Results of the Risk-Adapted, MRD-Stratified GMALL Trial 08/2013 in 281 T-ALL / T-Lbl Patients: Excellent Outcome of Standard Risk Thymic T-ALL

Free
Nicola Goekbuget, Walter Fiedler, Nael Alakel, Max S. Topp, Maher Hanoun, Björn Steffen, Ralph Wäsch, Andreas Viardot, Kathrin Nachtkamp, Matthias Stelljes, Hendrik Poeck, Vladan Vucinic, Boris Böll, Joachim Beck, Lars Fransecky, Knut Wendelin, Folker Schneller, Christoph Faul, Veit L Buecklein, Lena Reiser, Monika Brüggemann, Hubert Serve, Stefan Schwartz
Journal: Blood
Blood (2022) 140 (Supplement 1): 115–117.
https://doi.org/10.1182/blood-2022-158381
Published: 2022
Journal Articles

Immunomodulatory Microbial Metabolites Identified in Allo-SCT Patients Protect from GvHD By Sting Dependent Modulation of Intestinal Tissue Homeostasis

Free
Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Sakhila Ghimire, Paul Heinrich, Wolfgang Herr, Simon Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7336–7337.
https://doi.org/10.1182/blood-2022-169118
Published: 2022
Journal Articles

Overcoming CAR-T Cell Exhaustion and Improving Antitumoral Efficacy in Hematologic Neoplasms Utilizing CRISPR/Cas9 Technology

Free
Leonard Knoedler, Markus Perl, Luisa Becker, Hendrik Poeck, Christian Schmidl, Wolfgang Herr
Journal: Blood
Blood (2022) 140 (Supplement 1): 12701–12702.
https://doi.org/10.1182/blood-2022-167369
Published: 2022
Journal Articles

IFN-Gamma Producing Regulatory T Cells Counterbalance T Cell-Mediated Injury to the Intestinal Stem Cell Compartment in Mice and Humans

Free
Sascha Göttert, Julius Clemens Fischer, Gabriel Eisenkolb, Erik Thiele Orberg, Dirk Busch, Sebastian Jarosch, Ernst Holler, Thomas Engleitner, Lena Klostermeier, Caroline Walther, Laura Lansink Rotgerink, Sophie Nefzger, Marianne Reiser, Katja Steiger, Roland Rad, Stefanie E. Combs, Florian Bassermann, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 89.
https://doi.org/10.1182/blood-2021-152925
Published: 2021
Journal Articles

Microbial-Derived Metabolites Induce Epithelial Recovery Via the Sting Pathway in Mice and Men and Protect from Graft-Versus-Host Disease

Free
Erik Thiele Orberg, Sascha Göttert, Andreas Hiergeist, Elisabeth Meedt, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, Andre Gessner, Ernst Holler, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 87.
https://doi.org/10.1182/blood-2021-147794
Published: 2021