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Journal Articles

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR :: ABL1 -positive ALL

Clinical Trials & Observations Brief Report
Lorenz Bastian, Thomas Beder, Malwine J. Barz, Sonja Bendig, Lorenz Bartsch, Wencke Walter, Nadine Wolgast, Björn Brändl, Christian Rohrandt, Björn-Thore Hansen, Alina M. Hartmann, Katharina Iben, Dennis Das Gupta, Miriam Denker, Johannes Zimmermann, Michael Wittig, Guranda Chitadze, Martin Neumann, Folker Schneller, Walter Fiedler, Björn Steffen, Matthias Stelljes, Christoph Faul, Stefan Schwartz, Franz-Josef Müller, Gunnar Cario, Lana Harder, Claudia Haferlach, Heike Pfeifer, Nicola Gökbuget, Monika Brüggemann, Claudia D. Baldus
Journal: Blood
Blood (2024) 143 (14): 1391–1398.
https://doi.org/10.1182/blood.2023021752
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular Subtypes in BCR::ABL1 -Positive ALL Are Defined By Cellular Origins and Cooperating Genomic Events

Lorenz Bastian, Thomas Beder, Malwine Barz, Sonja Bendig, Lorenz Bartsch, Wencke Walter, Nadine Wolgast, Björn Brändl, Christian Rohrandt, Björn-Thore Hansen, Alina M. Hartmann, Katharina Iben, Miriam Bultmann, Johannes Zimmermann, Michael Wittig, Guranda Chitadze, Martin Neumann, Folker Schneller, Walter Fiedler, Björn Steffen, Matthias Stelljes, Christoph Faul, Stefan Schwartz, Franz-Josef Müller, Gunnar Cario, Lana Harder, Claudia Haferlach, Heike Pfeifer, Nicola Goekbuget, Monika Brüggemann, Claudia D Baldus
Journal: Blood
Blood (2023) 142 (Supplement 1): 843.
https://doi.org/10.1182/blood-2023-187315
Published: 2023
Journal Articles

Dose Reduced Chemotherapy in Sequence with Blinatumomab for Newly Diagnosed Older Patients with Ph/BCR::ABL Negative B-Precursor Adult Lymphoblastic Leukemia (ALL): Preliminary Results of the GMALL Bold Trial

Nicola Goekbuget, Stefan Schwartz, Christoph Faul, Max S. Topp, Marion Subklewe, Andrea Renzelmann, Andrea Stoltefuss, Bernd Hertenstein, Anne Wilke, Simon Raffel, Nadja Jäkel, Vladan Vucinic, Dirk Markus Niemann, Lena Reiser, Hubert Serve, Monika Brüggemann, Andreas Viardot
Journal: Blood
Blood (2023) 142 (Supplement 1): 964.
https://doi.org/10.1182/blood-2023-180472
Published: 2023
Journal Articles

CNS Irradiation in Adult De Novo B-Precursor ALL / Lbl: Results of the Randomized GMALL T rial 08/2013 Indicate Potential Antileukemic Efficacy

Nicola Goekbuget, Björn Steffen, Kathrin Nachtkamp, Boris Böll, Veit L. Buecklein, Christoph Faul, Jens Panse, Christoph Röllig, Folker Schneller, Bernd Spriewald, Matthias Stelljes, Max S. Topp, Andreas Viardot, Vladan Vucinic, Knut Wendelin, Monika Brüggemann, Monika Szczepanowski, Stefan Schwartz, Thomas Burmeister, Axel Benner, Nicholas Schreck, Lena Reiser, Hubert Serve, Walter Fiedler
Journal: Blood
Blood (2023) 142 (Supplement 1): 828.
https://doi.org/10.1182/blood-2023-179442
Published: 2023
Journal Articles

Outcome of 841 Older Patients (>55 yrs) with Newly Diagnosed Ph/BCR-ABL Negative ALL Prospectively Treated According to Pediatric-Based, Age-Adapted GMALL Protocols

Nicola Goekbuget, Andreas Viardot, Björn Steffen, Joachim Hahn, Bernd Spriewald, Sonja Martin, Simon Raffel, Lino L. Teichmann, Arne Trummer, Winfried Alsdorf, Anke Morgner, Stefan Schwartz, Matthias Stelljes, Vladan Vucinic, Nael Alakel, Andrea Stoltefuß, Claudia D. Baldus, Monika Brüggemann, Hubert Serve, Dieter Hoelzer
Journal: Blood
Blood (2022) 140 (Supplement 1): 121–123.
https://doi.org/10.1182/blood-2022-158934
Published: 2022
Journal Articles

Safety and Pharmacokinetics of Subcutaneous Blinatumomab (SC blinatumomab) for the Treatment of Adults with Relapsed or Refractory B Cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL); Results from a Phase 1b Study

Pilar Martínez Sánchez, Gerhard Zugmaier, Paul Gordon, Elias Jabbour, José J. Rifón Roca, Stefan Schwartz, Erika Borlenghi, Francoise Huguet, Jesús María Hernández-Rivas, Federico Lussana, Céline Berthon, Priti Kadu, Hansen Wong, Ana Markovic, Yuliya Katlinskaya, Alessandro Rambaldi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6122–6124.
https://doi.org/10.1182/blood-2022-157117
Published: 2022
Journal Articles

Results of the Risk-Adapted, MRD-Stratified GMALL Trial 08/2013 in 281 T-ALL / T-Lbl Patients: Excellent Outcome of Standard Risk Thymic T-ALL

Nicola Goekbuget, Walter Fiedler, Nael Alakel, Max S. Topp, Maher Hanoun, Björn Steffen, Ralph Wäsch, Andreas Viardot, Kathrin Nachtkamp, Matthias Stelljes, Hendrik Poeck, Vladan Vucinic, Boris Böll, Joachim Beck, Lars Fransecky, Knut Wendelin, Folker Schneller, Christoph Faul, Veit L Buecklein, Lena Reiser, Monika Brüggemann, Hubert Serve, Stefan Schwartz
Journal: Blood
Blood (2022) 140 (Supplement 1): 115–117.
https://doi.org/10.1182/blood-2022-158381
Published: 2022
Journal Articles

Expression of CD20 Affects Early MRD Response to Rituximab in Adult B Cell Precursor Lymphoblastic Leukemia of the GMALL 08/2013 Trial

Monika Szczepanowski, Johanna Richter, Miriam Kelm, Heiko Trautmann, Britta Kehden, Matthias Ritgen, Christoph Faul, Kathrin Nachtkamp, Björn Steffen, Andreas Viardot, Johannes Gärtner, Johannes Duell, Claudia D. Baldus, Stefan Schwartz, Nicola Goekbuget, Monika Brüggemann
Journal: Blood
Blood (2021) 138 (Supplement 1): 2301.
https://doi.org/10.1182/blood-2021-150375
Published: 2021
Journal Articles

Safety and Efficacy of Subcutaneous (SC) Blinatumomab for the Treatment of Adults with Relapsed or Refractory B Cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL)

Pilar Martínez Sánchez, Paul Gordon, Stefan Schwartz, Giuseppe Rossi, Francoise Huguet, Jesus Maria Hernández-Rivas, Priti Kadu, Hansen L. Wong, Ana Markovic, Yuliya Katlinskaya, Bharat Panwar, Gerhard Zugmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 2303.
https://doi.org/10.1182/blood-2021-150018
Published: 2021
Journal Articles

First Results of the Risk-Adapted, MRD-Stratified GMALL Trial 08/2013 in 705 Adults with Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma (ALL/LBL)

Nicola Goekbuget, Matthias Stelljes, Andreas Viardot, Kathrin Nachtkamp, Björn Steffen, Folker Schneller, Nael Alakel, Max Topp, Boris Böll, Christoph Faul, Karsten Spiekermann, Knut Wendelin, Maher Hanoun, Ralph Wäsch, Joachim Beck, Sonja Martin, Vladan Vucinic, Claudia D. Baldus, Monika Brüggemann, Thomas Burmeister, Heike Pfeifer, Stefan Schwartz, Lena Baumann, Diana Tichy, Hubert Serve, Walter Fiedler
Journal: Blood
Blood (2021) 138 (Supplement 1): 362.
https://doi.org/10.1182/blood-2021-146306
Published: 2021
Journal Articles

Dose Reduced Chemotherapy in Sequence with Blinatumomab for Newly Diagnosed Older Patients with B-Precursor Adult Lymphoblastic Leukemia (ALL): Results of the Ongoing GMALL Bold Trial

Nicola Goekbuget, Andrea Stoltefuß, Max Topp, Stefan Schwartz, Andrea Renzelmann, Christoph Faul, Bernd Hertenstein, Vladan Vucinic, Maria Wachsmuth, Anne C Wilke, Lena Baumann, Diana Tichy, Monika Brüggemann, Andreas Viardot
Journal: Blood
Blood (2021) 138 (Supplement 1): 3399.
https://doi.org/10.1182/blood-2021-146214
Published: 2021
Journal Articles

Molecular Subgroups of T Cell Acute Lymphoblastic Leukemia in Adults Treated According to GMALL Protocols

Martin Neumann, Lorenz Bastian, Sonja Hänzelmann, Alina Hartmann, Heiko Trautmann, PhD, Jutta Ortiz Tanchez, Cornelia Schlee, Michael P Schroeder, PhD, Lars R. Fransecky, MD, Sebastian Vosberg, Walter Fiedler, MD, Nael Alakel, MD, Mustafa Kondakci, MD, Michael Starck, MD, Stefan Schwartz, MD PhD, Carsten Müller-Tidow, MD, Folker Schneller, Albert Reichle, Thomas Burmeister, Philipp A. Greif, MD PD, Monika Brüggemann, MD, Nicola Goekbuget, MD, Claudia D Baldus, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-141921
Published: 2020
Journal Articles

Interim Results of a Multicenter, Single-Arm Study to Assess Blinatumomab in Adult Patients (pts) with Minimal Residual Disease (MRD) of B-Precursor (BCP) Acute Lymphoblastic Leukemia (GMALL-MOLACT1-BLINA)

Nicola Goekbuget, MD, Wiba Keke Wermann, Stefan Schwartz, MD PhD, Andreas Hüttmann, MD, Christoph Faul, MD, Simon Raffel, MD, Andreas Viardot, Professor Dr, Walter Fiedler, MD, Nael Alakel, MD, Matthias Stelljes, MD, Marion Subklewe, MD, Ralph Wäsch, Sonja Martin, MD, Wolfram Jung, MD, Vladan Vucinic, MD, Mustafa Kondakci, MD, Lars R. Fransecky, MD, Daniela Heidenreich, MD, Knut Wendelin, MD, Julian Hermann, Hubert Serve, MD PhD, Ralf C Bargou, MD PhD, Max S. Topp, MD, Monika Brüggemann, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-137350
Published: 2020
Journal Articles

Molecular Subtypes with Distinct Clinical Phenotypes and Actionable Targets in Adult B Cell Precursor ALL Treatment According to GMALL Protocols

Lorenz Bastian, Sonja Hänzelmann, Martin Neumann, Alina Hartmann, Thomas Burmeister, Stefan Schwartz, Walter Fiedler, MD, Mustafa Kondakci, MD, Andreas Viardot, Professor Dr, Folker Schneller, Christoph Faul, MD, Max S. Topp, MD, Sören Franzenburg, Andre Franke, Heiko Trautmann, PhD, Nicola Goekbuget, MD, Monika Brüggemann, MD, Claudia D Baldus, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-143032
Published: 2020
Journal Articles

Homocygous PAX5 Sequence Mutations Define a Novel Subtype of B Cell Precursor Acute Lymphoblastic Leukemia

Lorenz Bastian, Michael P Schroeder, PhD, Cornelia Eckert, PhD, Cornelia Schlee, Jutta Ortiz Tanchez, Sebastian Kämpf, Dimitrios L. Wagner, Veronika Schulze, Konstandina Isaakidis, Alva Rani James, Thomas Burmeister, Stefan Schwartz, MD, Sebastian Vosberg, Stefan Krebs, PhD, Helmut Blum, PhD, Jochen Hecht, PhD, Philipp A. Greif, MD, Michael A. Rieger, PhD, Monika Brüggemann, MD, Nicola Goekbuget, MD, Carsten Müller-Tidow, Hubert Serve, Martin Neumann, Claudia D. Baldus, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2713.
https://doi.org/10.1182/blood.V130.Suppl_1.2713.2713
Published: 2017
Journal Articles

Multi-Omics of Adult T Cell Acute Lymphoblastic Leukemia

Martin Neumann, Michael P Schroeder, PhD, Lorenz Bastian, Jutta Ortiz Tanchez, Cornelia Schlee, Konstandina Isaakidis, Alva Rani James, Lars R. Fransecky, Sebastian Vosberg, Stefan Krebs, PhD, Helmut Blum, PhD, Stefan Schwartz, MD, Thomas Burmeister, Dieter Hoelzer, MD PhD, Philipp A. Greif, MD, Monika Brüggemann, Nicola Goekbuget, MD, Claudia D. Baldus, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2725.
https://doi.org/10.1182/blood.V130.Suppl_1.2725.2725
Published: 2017
Journal Articles

Multi-Genomics of Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Three Distinct Genetic Clusters Characterized By Different Alterations

Michael P Schroeder, PhD, Martin Neumann, MD, Cornelia Eckert, PhD, Lorenz Bastian, MD, Alva Rani James, Nicola Gökbuget, MD, Cornelia Schlee, Jutta Ortiz Tanchez, Konstandina Isaakidis, Stefan Schwartz, MD, Thomas Burmeister, MD, Dieter Hoelzer, MD, Heike Pfeiffer, MD, Michael A Rieger, PhD, Stefanie Göllner, PhD, Thomas Oellerich, MD, Diego Yepes, PhD, Renate Kirschner-Schwabe, PhD, Monika Brüggemann, MD PhD, Carsten Müller-Tidow, Hubert Serve, MD, Claudia D. Baldus, MD
Journal: Blood
Blood (2016) 128 (22): 453.
https://doi.org/10.1182/blood.V128.22.453.453
Published: 2016
Journal Articles

Genomic Profiling Reveals Gain of Mutations in Histone Methylation Regulators in Relapsed Adult B Cell Precursor ALL

Lorenz Bastian, Martin Neumann, MD, Nicola Gökbuget, MD, Cornelia Schlee, Jutta Ortiz Tanchez, Sebastian Vosberg, Alva Rani James, Michael P Schroeder, Stefan Schwartz, MD, Dieter Hoelzer, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Jochen Hecht, Monika Brüggemann, Philipp A. Greif, Claudia D. Baldus, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2625.
https://doi.org/10.1182/blood.V126.23.2625.2625
Published: 2015
Journal Articles

Non-Functional ("haploinsufficient"), but Not Dominant Negative Clonal IKZF1 Deletions Confer an Adverse Prognosis in Adult BCR-ABL -Negative Acute Lymphoblastic Leukemia

Benjamin Kobitzsch, Nicola Gökbuget, MD, Stefan Schwartz, MD, Richard Reinhardt, PhD, Monika Brueggemann, Andreas Viardot, MD, Ralph Wäsch, MD PhD, Michael Starck, MD, Eckhard Thiel, MD, Dieter Hoelzer, MD, Thomas Burmeister, MD
Journal: Blood
Blood (2015) 126 (23): 2617.
https://doi.org/10.1182/blood.V126.23.2617.2617
Published: 2015
Journal Articles

Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial

Clinical Trials & Observations
Dieter Hoelzer, Jan Walewski, Hartmut Döhner, Andreas Viardot, Wolfgang Hiddemann, Karsten Spiekermann, Hubert Serve, Ulrich Dührsen, Andreas Hüttmann, Eckhard Thiel, Jolanta Dengler, Michael Kneba, Markus Schaich, Ingo G. H. Schmidt-Wolf, Joachim Beck, Bernd Hertenstein, Albrecht Reichle, Katarzyna Domanska-Czyz, Rainer Fietkau, Heinz-August Horst, Harald Rieder, Stefan Schwartz, Thomas Burmeister, Nicola Gökbuget
Journal: Blood
Blood (2014) 124 (26): 3870–3879.
https://doi.org/10.1182/blood-2014-03-563627
Published: 2014
Includes: Supplemental data