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Shannon L. Maude
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Journal Articles

Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents

Clinical Trials & Observations
Caroline Diorio, Laura Hernandez-Miyares, Diego A. Espinoza, Brenda L. Banwell, Amit Bar-Or, Amanda M. DiNofia, Allison Barz Leahy, Zachary Martinez, Regina M. Myers, Sarah E. Hopkins, Susan R. Rheingold, David T. Teachey, Angela N. Viaene, Lisa M. Wray, Shannon L. Maude, Stephan A. Grupp, Jennifer L. McGuire
Journal: Blood
Blood (2024) 144 (13): 1387–1398.
https://doi.org/10.1182/blood.2024023933
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes and Toxicities after Allogeneic Hematopoietic Cell Transplant for Remission Consolidation or Relapse Therapy after CD19 Chimeric Antigen Receptor T Cell Therapy in Children and Young Adults with Acute Lymphoblastic Leukemia

Regina M. Myers, Sarah Mumanachit, Shannon L. Maude, Amanda M. Dinofia, Jason L. Freedman, Nancy Bunin, Lisa Wray, Allison Barz Leahy, Timothy S Olson, Stephan Grupp, Alix E. Seif, Caitlin W. Elgarten
Journal: Blood
Blood (2023) 142 (Supplement 1): 3767.
https://doi.org/10.1182/blood-2023-188047
Published: 2023
Journal Articles

Phase 1/2 Dose-Escalation/Dose-Expansion Study of Anti-CD7 Allogeneic CAR-T Cells (WU-CART-007) in Relapsed or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma (T-ALL/LBL)

Armin Ghobadi, Ibrahim Aldoss, Shannon L. Maude, Deepa Bhojwani, Alan S. Wayne, Ashish Bajel, Rawan Faramand, Ryan J Mattison, Bhagirathbhai Dholaria, Michael P. Rettig, Ken Jacobs, Ouiam Bakkacha, John Muth, Angela Pannunzio, Brett Ramsey, Eileen McNulty, Matt L. Cooper, Jan Davidson-Moncada, John F. DiPersio
Journal: Blood
Blood (2023) 142 (Supplement 1): 770.
https://doi.org/10.1182/blood-2023-178723
Published: 2023
Journal Articles

Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Haley Newman, Yimei Li, Hongyan Liu, Regina M. Myers, Vicky Tam, Amanda DiNofia, Lisa Wray, Susan R. Rheingold, Colleen Callahan, Claire White, Diane Baniewicz, Lena E. Winestone, Stephan Kadauke, Caroline Diorio, Carl H. June, Kelly D. Getz, Richard Aplenc, David T. Teachey, Shannon L. Maude, Stephan A. Grupp, Kira Bona, Allison Barz Leahy
Journal: Blood
Blood (2023) 141 (6): 609–619.
https://doi.org/10.1182/blood.2022017866
Published: 2023
Includes: Supplemental data
Journal Articles

Obesity Associates with Inferior Outcomes and Toxicity in Pediatric and Young Adult Patient with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Treated with Commercially Manufactured Tisagenlecleucel

Anthony J Ross, Christina Baggott, Snehit Prabhu, Holly Pacenta, Christine Philips, Jenna Rossoff, Heather E Stefanski, Julie Talano, Amy Moskop, Susanne H.C. Baumeister, Michael R Verneris, Gary Douglas Myers, Nicole Karras, Muna Qayed, Michelle L. Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Rachel Wilcox, Vanessa A Fabrizio, Vasant Chinnabhandar, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, Sandra K Althouse, Shannon L. Maude, Curtis J Henry, Liora M. Schultz, Jodi L. Skiles
Journal: Blood
Blood (2022) 140 (Supplement 1): 10419–10421.
https://doi.org/10.1182/blood-2022-163336
Published: 2022
Journal Articles

CD22-Targeted CAR-Modified T-Cells Safely Induce Remissions in Children and Young Adults with Relapsed, CD19-Negative B-ALL after Treatment with CD19-Targeted CAR T-Cells

Regina M. Myers, Amanda M. DiNofia, Yimei Li, Caroline Diorio, Richard Aplenc, Diane Baniewicz, Jennifer L Brogdon, Colleen Callahan, Boris Engels, Joseph A. Fraietta, Vanessa Gonzalez, Emma Iannone, Allison Barz Leahy, Hongyan Liu, Susan E. McClory, Susan R. Rheingold, Laura Shinehouse, Gerald Wertheim, Lisa Wray, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp
Journal: Blood
Blood (2022) 140 (Supplement 1): 2376–2377.
https://doi.org/10.1182/blood-2022-168139
Published: 2022
Journal Articles

Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Allison Barz Leahy, Kaitlin J. Devine, Yimei Li, Hongyan Liu, Regina Myers, Amanda DiNofia, Lisa Wray, Susan R. Rheingold, Colleen Callahan, Diane Baniewicz, Maria Patino, Haley Newman, Stephen P. Hunger, Stephan A. Grupp, David M. Barrett, Shannon L. Maude
Journal: Blood
Blood (2022) 139 (14): 2173–2185.
https://doi.org/10.1182/blood.2021012727
Published: 2022
Includes: Supplemental data
Journal Articles

A Phase 1/2 Dose-Escalation and Dose-Expansion Study of the Safety and Efficacy of Anti-CD7 Allogeneic CAR-T Cells (WU-CART-007) in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/ Lymphoblastic Lymphoma (LBL)

Armin Ghobadi, Ibrahim Aldoss, Frederick L. Locke, Ryan J. Mattison, Deepa Bhojwani, Shannon L. Maude, Preeta Dasgupta, Karen Gheesling Mullis, Ayman Kabakibi, Alexander S. Hamil, Tom Leedom, Kenneth Chrobak, Eileen McNulty, Jan K Davidson-Moncada, Matthew L Cooper, John F. DiPersio
Journal: Blood
Blood (2021) 138 (Supplement 1): 4829.
https://doi.org/10.1182/blood-2021-146841
Published: 2021
Journal Articles

Outcomes after Reinfusion of CD19-Specific Chimeric Antigen Receptor (CAR)-Modified T Cells in Children and Young Adults with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Regina M. Myers, Kaitlin Devine, Yimei Li, Sophie Lawrence, Allison Barz Leahy, Hongyan Liu, Lauren Vernau, Colleen Callahan, Diane Baniewicz, Stephan Kadauke, Regina McGuire, Margaret A Cameron, Amanda M. DiNofia, Susan R. Rheingold, Richard Aplenc, Carl H June, Stephan A. Grupp, Lisa Wray, Shannon L. Maude
Journal: Blood
Blood (2021) 138 (Supplement 1): 474.
https://doi.org/10.1182/blood-2021-147299
Published: 2021
Journal Articles

Comprehensive Secretome Profiling Elucidates Novel Disease Biology and Identifies Pre-Infusion Candidate Biomarkers to Predict the Development of Severe Cytokine Release Syndrome in Pediatric Patients Receiving CART19

Caroline Diorio, Rawan Shraim, Regina M. Myers, Chakkapong Burudpakdee, Allison Barz Leahy, Richard Aplenc, Michele P. Lambert, Hamid Bassiri, Edward M Behrens, Vanessa E. Gonzalez, Fang Chen, Bruce L Levine, Shannon L. Maude, Amanda M. DiNofia, Alix E. Seif, J. Joseph Melenhorst, Simon F Lacey, Carl H June, David Barrett, Stephan A. Grupp, David T. Teachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 167.
https://doi.org/10.1182/blood-2021-149477
Published: 2021
Journal Articles

Complete Versus Incomplete Hematologic Recovery after CAR T Cell Therapy: Implications for Relapse Free Survival and Overall Survival in Pediatric and Young Adult Patients with Relapsed/Refractory B-ALL

Benjamin J Lerman, Yimei Li, Hongyan Liu, Regina M. Myers, Kaitlin Devine, Colleen Callahan, Diane Baniewicz, Stephan Kadauke, Amanda M. DiNofia, Susan R. Rheingold, Lisa Wray, Richard Aplenc, Stephan A. Grupp, Shannon L. Maude, Allison Barz Leahy
Journal: Blood
Blood (2021) 138 (Supplement 1): 1747.
https://doi.org/10.1182/blood-2021-151114
Published: 2021
Journal Articles

CAR T cell viability release testing and clinical outcomes: is there a lower limit?

Elise A. Chong, Bruce L. Levine, Stephan A. Grupp, Megan M. Davis, Don L. Siegel, Shannon L. Maude, Whitney L. Gladney, Noelle V. Frey, David L. Porter, Wei-Ting Hwang, Emeline R. Chong, Carl H. June, Stephen J. Schuster
Journal: Blood
Blood (2019) 134 (21): 1873–1875.
https://doi.org/10.1182/blood.2019002258
Published: 2019
Journal Articles

Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors

Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L Garfall, MD, Michael C. Milone, Lifeng Tian, PhD, Vanessa E. Gonzalez, Saar Gill, MD MRCP, FRCPath, Noelle V. Frey, MD, David M. Barrett, Marco Ruella, MD, Simon F Lacey, PhD, Jakub Svoboda, MD, Elise A. Chong, MD, Joseph A Fraietta, PhD, Megan Davis, PhD, Sunita D Nasta, MD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Shannon L. Maude, MD PhD, Stephen J. Schuster, MD, Edward A. Stadtmauer, MD FACP, Stephan Grupp, MD PhD, David L. Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 622.
https://doi.org/10.1182/blood-2019-122513
Published: 2019
Journal Articles

Cytogenetic Characteristics and Outcomes of Patients Receiving CTL019 CAR T Cell Therapy

Allison Barz Leahy, MD, Kaitlin J. Stanley, MD, Regina M. Myers, MD, Amanda M. DiNofia, MD, Lisa Wray, MD, Susan R. Rheingold, MD, Colleen Callahan, CRNP, Diane Baniewicz, CRNP, Amy E. Barry, PPCNP-BC, Maria M. Patino, BS, Stephen P. Hunger, MD, Stephan Grupp, MD PhD, David M. Barrett, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1464.
https://doi.org/10.1182/blood-2019-130060
Published: 2019
Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

Trends in Inpatient and Intensive Care Resource Utilization after Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia from 2012-2019

Regina M. Myers, MD, Julie C Fitzgerald, MD, Amanda M. DiNofia, MD, Lisa Wray, MD, Allison Barz Leahy, MD, Yimei Li, PhD, Laura Smith, RN, MSN, CRNP, Evanette Burrows, MPH, Mark Ramos, BS, Laura S Motley, BSc, BSN, RN, Raabia N Khan, MPH, Kelly D Getz, Richard Aplenc, MD PhD, Stephan Grupp, MD PhD, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 61.
https://doi.org/10.1182/blood-2019-126724
Published: 2019
Journal Articles

High Vs. Low-Intensity Bridging Chemotherapy in Children with Acute Lymphoblastic Leukemia Awaiting Chimeric Antigen Receptor T-Cell Therapy: A Population-Based Study from Ontario, Canada

Sumit Gupta, MD, Sarah Alexander, MD, Sue Zupanec, RN, Uma Athale, MDMBBS,MSc, Mylene Bassal, MD, Ethan Edwards, Paul J. Gibson, MD, Donna Johnston, MDFRCPC, Stacey Marjerrison, MD, Alexander Zorzi, MD, Johann K. Hitzler, MD, Ahmed Naqvi, MD, Angela Punnett, MD, James A. Whitlock, MD, Stephan A. Grupp, MD PhD, Shannon L. Maude, MD PhD, Joerg Krueger, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1410.
https://doi.org/10.1182/blood-2018-99-115593
Published: 2018
Journal Articles

Checkpoint Inhibitors Augment CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Relapsed B-Cell Acute Lymphoblastic Leukemia

Amanda M. Li, MD, George E Hucks, Amanda M. Dinofia, MD, Alix E. Seif, MD, David T Teachey, MD, Diane Baniewicz, Colleen Callahan, Christina Fasano, Beth McBride, Vanessa Gonzalez, Farzana Nazimuddin, MS, David L. Porter, MD, Simon F Lacey, PhD BS, Carl H June, MD, Stephan A. Grupp, MD PhD, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 556.
https://doi.org/10.1182/blood-2018-99-112572
Published: 2018
Journal Articles

CD19-Directed CAR T-Cell (CTL019) Product Viability and Clinical Outcomes in Non-Hodgkin Lymphomas and B-Cell Acute Lymphoblastic Leukemia

Elise A. Chong, MD, Bruce L Levine, PhD, Stephan A. Grupp, MD PhD, Megan Davis, PhD, Don L. Siegel, MD PhD, Shannon L. Maude, MD PhD, Whitney Lynn Gladney, PhD, Noelle V. Frey, MD, David L. Porter, MD, Carl H June, MD, Stephen J. Schuster, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 197.
https://doi.org/10.1182/blood-2018-197
Published: 2018
Journal Articles

Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia

Stephan A. Grupp, MD PhD, Shannon L. Maude, MD PhD, Susana Rives, MD PhD, Andre Baruchel, MD, Michael W. Boyer, MD, Henrique Bittencourt, MD PhD, Peter Bader, MD PhD, Jochen Büchner, MDPhD, Theodore W. Laetsch, MD, Heather Stefanski, MDPhD, Gary Douglas Myers, MD, Muna Qayed, MD MSc, Michael A. Pulsipher, MD, Barbara De Moerloose, MD PhD, Gregory A. Yanik, MD, Kara L. Davis, DO, Paul L. Martin, MD PhD, Eneida R. Nemecek, MD, Christina Peters, MD, Joerg Krueger, MD, Adriana Balduzzi, MD, Nicolas Boissel, MD PhD, Francoise Marie Mechinaud, MD FRACP, Mimi Leung, Lamis K. Eldjerou, MD, Lan Yi, PhD, Karen Thudium Mueller, PharmD,MSc, Eric Bleickardt, MD, Hidefumi Hiramatsu, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 895.
https://doi.org/10.1182/blood-2018-99-112599
Published: 2018