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Gabriela Plesa
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Journal Articles

Single-day non-activated IL-18-armed CAR T cells with enhanced persistence and durable efficacy

Free
Joseph Durgin, Shin Seo, Shadab Kazmi, Bakir Valentic, Chloe Leff, Xioling Jin, Feng Shen, Nandana Mukherjee, Ashwin Sannecy, Gabriela Plesa, Khatuna Gabunia, John Scholler, Saar Gill, Roddy O'Connor, Carl June, Saba Ghassemi
Journal: Blood
Blood (2025) 146 (Supplement 1): 4187.
https://doi.org/10.1182/blood-2025-4187
Published: 2025
Journal Articles

IL18-armored CAR T cells in patients with CLL/SLL and Richter's transformation after prior BTK inhibitor and venetoclax failure

Free
Jakub Svoboda, Stephen Schuster, David Porter, Michael Cook, Sunita Dwivedy Nasta, Daniel Landsburg, Stefan Barta, Marco Ruella, Elise Chong, Jordan Carter, Colin Thomas, Emily Tomasulo, Noelle Frey, Matthew Connor, Joanne Shea, Amanda Cervini, Jean McConville, Charles Tongue, Megan Four, Amy Marshall, Wei-Ting Hwang, Rachel Leskowitz, Vanessa Gonzalez, Shannon Christensen, Gabriela Plesa, Don Siegel, Julie Jadlowsky, Joseph Fraietta, Bruce Levine, Elizabeth Hexner, Carl June
Journal: Blood
Blood (2025) 146 (Supplement 1): 2394.
https://doi.org/10.1182/blood-2025-2394
Published: 2025
Journal Articles

CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric b ALL

Free
Amanda DiNofia, Regina Myers, Yimei Li, Hongyan Liu, Richard Aplenc, Diane Baniewicz, Allison Barz Leahy, Lucy Cain, Colleen Callahan, Caroline Diorio, Joseph Fraietta, Elizabeth Hexner, Caitlin Hopkins, Stephen Hunger, Vanessa Gonzalez, Julie Jadlowsky, Mariam Kerolos, Raabia Khan, Susan McClory, Shannon Maude, Gabriela Plesa, Susan Rheingold, Mackenzie Stewart, Sarah Tasian, Melissa Varghese, Lisa Wray, Stephan Grupp
Journal: Blood
Blood (2025) 146 (Supplement 1): 648.
https://doi.org/10.1182/blood-2025-648
Published: 2025
Journal Articles

Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia

Free
Lucy Cain, Yimei Li, Hongyan Liu, Shannon Christensen, Regina Myers, Allison Barz Leahy, Caroline Diorio, Nancy Shapiro, Elizabeth McBride, Colleen Callahan, Diane Baniewicz, Amanda DiNofia, Susan Rheingold, Lisa Wray, Stephen Hunger, Richard Aplenc, Susan McClory, Mackenzie Stewart, Gerald Wertheim, Andrew Fesnak, Gabriela Plesa, Don Siegel, Joseph Fraietta, Vanessa Gonzalez, Caitlin Hopkins, Amy Marshall, Amanda Kotch, Bruce Levine, Anne Chew, Elizabeth Hexner, Carl June, Stephan Grupp, Shannon Maude
Journal: Blood
Blood (2025) 146 (Supplement 1): 646.
https://doi.org/10.1182/blood-2025-646
Published: 2025
Journal Articles

CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia

Free
Lucy Cain, Yimei Li, Anand Bhagwat, Diane Baniewicz, Allison Barz Leahy, Colleen Callahan, Shannon Christensen, Angela Cosey, Amanda DiNofia, Caroline Diorio, Joseph Fraietta, Vanessa Gonzalez, Elizabeth Hexner, Stephen Hunger, Amy Marshall, Shannon Maude, Susan McClory, Regina Myers, Gabriela Plesa, Susan Rheingold, Aakruti Sharma, Mackenzie Stewart, Lisa Wray, Earline Young-Robinson, Stephan Grupp, Saar Gill, Sarah Tasian, Richard Aplenc
Journal: Blood
Blood (2025) 146 (Supplement 1): 1643.
https://doi.org/10.1182/blood-2025-1643
Published: 2025
Journal Articles

IL18-armored CAR T cells in relapsed/refractory B cell acute lymphoblastic leukemia

Free
Matthew Connor, Wei-Ting Hwang, Saar Gill, Alexander Perl, Ximena Jordan Bruno, Nasheed Hossain, Catherine Lai, Alison Loren, Selina Luger, Andrew Matthews, Shannon McCurdy, Pashna Munshi, Keith Pratz, Amanda Cervini, Jean McConville, Joanne Shea, Charles Tongue, Heather Difilippo, Jacob Kesselman, Amy Marshall, Megan Four, Shannon Christensen, Vanessa Gonzalez, Julie Jadlowsky, Gabriela Plesa, Don Siegel, Rachel Leskowitz, Joseph Fraietta, Bruce Levine, David Porter, Elizabeth Hexner, Carl June, Jakub Svoboda, Noelle Frey
Journal: Blood
Blood (2025) 146 (Supplement 1): 812.
https://doi.org/10.1182/blood-2025-812
Published: 2025
Journal Articles

In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Free
Caitlin R. Hopkins, Amanda M. DiNofia, Shannon L. Maude, Gregory M. Chen, Kwame Attah M. Boateng-Antwi, Jessica Perazzelli, Andres F. Mendez Corea, Alexander Shestov, Mercy Gohil, Yimei Li, Wei-Ting Hwang, Bakir Valentić, Shannon Christensen, Julie Jadlowsky, Regina M. Myers, Caroline Diorio, Megan M. Davis, Theresa Colligon, Gabriela Plesa, Don L. Siegel, Bruce Levine, Carl H. June, Roddy S. O'Connor, Stephan A. Grupp, Joseph A. Fraietta
Journal: Blood
Blood (2024) 144 (Supplement 1): 3473.
https://doi.org/10.1182/blood-2024-210324
Published: 2024
Journal Articles

Interleukin-18 Secreting Autologous Anti-CD19 CAR T-Cells (huCART19-IL18) in Patients with Non-Hodgkin Lymphomas Relapsed or Refractory to Prior CAR T-Cell Therapy

Free
Jakub Svoboda, James N. Gerson, Daniel J. Landsburg, Elise A. Chong, Stefan K. Barta, Sunita Dwivedy Nasta, Marco Ruella, Elizabeth O. Hexner, Amy Marshall, Rachel Leskowitz, Megan Four, Joanne Shea, Tina Matlawski, Amanda Cervini, Megan M. Davis, Mercy Gohil, John Scholler, Donald Hasenmayer, Juliana Rojas Amortegui, Andrea Brennan, Gabriela Plesa, Wei-Ting Hwang, David L. Porter, Joseph Fraietta, Stephen J. Schuster, Carl H. June
Journal: Blood
Blood (2022) 140 (Supplement 1): 4612–4614.
https://doi.org/10.1182/blood-2022-162393
Published: 2022
Journal Articles

First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma

Free
Edward A. Stadtmauer, MD FACP, Adam D. Cohen, MD, Kristy Weber, MD, Simon F Lacey, PhD, Vanessa E. Gonzalez, J. Joseph Melenhorst, PhD, Joseph A Fraietta, PhD, Gabriela Plesa, MD, Joanne Shea, Tina Matlawski, RN, Amanda Cervini, RN, Patricia Mangan, CRNP, Avery Gaymon, Stephanie Desjardins, Eric Lancaster, MD, January Salas-Mckee, Megan M. Suhoski, PhD, Andrew Fesnak, MD, Matthew O'Rourke, Anne Lamontagne, Don L. Siegel, MD PhD, Regina M Young, PhD, Anne Chew, PhD, Christopher L Nobles, PhD, Frederic D. Bushman, PhD, Howard Y. Chang, MD PhD, Ansuman T. Satpathy, MD PhD, Yangbing Zhao, PhD MD, Wei-Ting Hwang, PhD, Elizabeth O. Hexner, MDMS, Carl H June, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 49.
https://doi.org/10.1182/blood-2019-122374
Published: 2019
Journal Articles

PD-1 Inhibitor Combinations As Salvage Therapy for Relapsed/Refractory Multiple Myeloma (MM) Patients Progressing after Bcma-Directed CAR T Cells

Free
Luca Bernabei, Alfred L. Garfall, MD, J. Joseph Melenhorst, PhD, Simon F Lacey, PhD BS, Edward A. Stadtmauer, MD FACP, Dan T. Vogl, MD, Vanessa Gonzalez, Gabriela Plesa, MD, Regina M Young, PhD, Adam Waxman, MD, Bruce L Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD, Adam D. Cohen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1973.
https://doi.org/10.1182/blood-2018-99-119514
Published: 2018
Journal Articles

Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Refractory Multiple Myeloma (MM)

Free
Adam D. Cohen, MD, J. Joseph Melenhorst, PhD, Alfred L. Garfall, MD, Simon F Lacey, PhD BS, Megan Davis, PhD, Dan T. Vogl, MD, Lifeng Tian, PhD, Vanessa Gonzalez, Iulian Pruteanu, PhD, Anne Marie Nelson, Gabriela Plesa, MD, Adam Waxman, MD, Regina M Young, PhD, Bruce L Levine, PhD, Carl H June, MD, Edward A. Stadtmauer, MD FACP, Michael C. Milone, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1974.
https://doi.org/10.1182/blood-2018-99-119665
Published: 2018
Journal Articles

Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (MM)

Free
Adam D. Cohen, MD, Alfred L. Garfall, MD, Edward A. Stadtmauer, MD FACP, Simon F Lacey, PhD BS, Eric Lancaster, Dan T. Vogl, MD, Brendan M Weiss, MD, David E Ambrose, BS, Anne Marie Nelson, Fang Chen, PhD, Gabriela Plesa, MD, Irina Kulikovskaya, Vanessa Gonzalez, Minnal Gupta, Regina M Young, PhD, Karen Dengel, BSN, RN, Laura O'keefe, Samantha Le, Celeste Richardson, PhD, Randi E. Isaacs, MD, J. Joseph Melenhorst, PhD, Bruce L Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 505.
https://doi.org/10.1182/blood.V130.Suppl_1.505.505
Published: 2017
Journal Articles

B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) for Multiple Myeloma (MM): Initial Safety and Efficacy from a Phase I Study

Free
Adam D. Cohen, MD, Alfred L. Garfall, MD, Edward A Stadtmauer, MD, Simon Francis Lacey, PhD BS, Eric Lancaster, MD PhD, Dan T. Vogl, MD, Karen Dengel, BSN, RN, David E Ambrose, BS, Fang Chen, PhD, Gabriela Plesa, PhD, Irina Kulikovskaya, PhD, Vanessa E Gonzalez, M.B.A, Minnal Gupta, MSc, Regina M Young, PhD, Tenesia Carey, Regina Ferthio, Brendan M. Weiss, MD, Celeste Richardson, PhD, Randi E. Isaacs, MD, J. Joseph Melenhorst, PhD, Bruce L. Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1147.
https://doi.org/10.1182/blood.V128.22.1147.1147
Published: 2016
Journal Articles

Posterior Reversible Encephalopathy Syndrome (PRES) after Infusion of Anti-Bcma CAR T Cells (CART-BCMA) for Multiple Myeloma: Successful Treatment with Cyclophosphamide

Free
Alfred L. Garfall, MD, Eric Lancaster, MD PhD, Edward A Stadtmauer, MD, Simon F. Lacey, PhD, Karen Dengel, BSN, RN, David E Ambrose, BS, Fang Chen, PhD, Minnal Gupta, MSc, Irina Kulikovskaya, PhD, Dan T. Vogl, MD, Gabriela Plesa, PhD, Brendan M Weiss, MD, Regina Ferthio, Celeste Richardson, PhD, Jan Joseph Melenhorst, PhD, Bruce L Levine, PhD, Carl H June, MD, Michael Milone, MD PhD, Adam D. Cohen, MD
Journal: Blood
Blood (2016) 128 (22): 5702.
https://doi.org/10.1182/blood.V128.22.5702.5702
Published: 2016
Journal Articles

TCR affinity and specificity requirements for human regulatory T-cell function

Free
Gabriela Plesa, Lingjie Zheng, Andrew Medvec, Caleph B. Wilson, Camila Robles-Oteiza, Nathaniel Liddy, Alan D. Bennett, Jessie Gavarret, Annelise Vuidepot, Yangbing Zhao, Bruce R. Blazar, Bent K. Jakobsen, James L. Riley
Journal: Blood
Blood (2012) 119 (15): 3420–3430.
https://doi.org/10.1182/blood-2011-09-377051
Published: 2012
Includes: Supplemental data