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Journal Articles

Chronic graft-versus-host disease: unresolved complication or ancient history?

Joseph A. Pidala, Ted A. Gooley, Leo Luznik, Bruce R. Blazar

Blood (2024) 144 (13): 1363–1373.

https://doi.org/10.1182/blood.2023022735

Published: 2024

Includes: Supplemental data

Journal Articles

CD8 + T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia

Francesco Mazziotta, Luca Biavati, Joseph Rimando, Sergio Rutella, Nicholas Borcherding, Sonali Parbhoo, Rupkatha Mukhopadhyay, Sayan Chowdhury, Hanna A. Knaus, Peter Valent, Hubert Hackl, Ivan M. Borrello, Bruce R. Blazar, Katerina Hatzi, Ivana Gojo, Leo Luznik

Blood (2024) 144 (11): 1168–1182.

https://doi.org/10.1182/blood.2023021680

Published: 2024

Includes: Supplemental data

Journal Articles

JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 cells: Final Phase II Trial Results

Blood blood.2024024789.

https://doi.org/10.1182/blood.2024024789

Published: 2024

Includes: Supplemental data

Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood (2024) 143 (21): 2201–2216.

https://doi.org/10.1182/blood.2023023549

Published: 2024

Includes: Supplemental data

Journal Articles

ACC1 Inhibition Enhances Treg Gvhd Treatment Efficacy through Regulation of Mitochondrial Fusion and Elongation

Cameron McDonald-Hyman, Ethan G Aguilar, Stephanie Y Rhee, Fathima A Mohamed, Ewaldus Compeer, Timothy Sparwassar, Michael Dustin, Bruce R Blazar

Blood (2023) 142 (Supplement 1): 4819.

https://doi.org/10.1182/blood-2023-187306

Published: 2023

Journal Articles

Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction

Fathima A Mohamed, Stephanie Y Rhee, Joanna Ly, Ethan G Aguilar, Haley Melin, Peter T Sage, Tanner Schumacher, Govindarajan Thangavelu, Michael C Zaiken, Juan Liu, Venkatram Mereddy, Jason W Locasale, Bruce R Blazar

Blood (2023) 142 (Supplement 1): 459.

https://doi.org/10.1182/blood-2023-185200

Published: 2023

Journal Articles

JAK2/mTOR Inhibition Fails to Prevent Acute Gvhd Despite Reduced Th1/Th17 Cells: Final Phase II Trial Results

Joseph Pidala, Shernan G. Holtan, Kelly Walton, Jongphil Kim, Hany Elmariah, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia Perez, Rawan Faramand, Marco Davila, Claudio Anasetti, Daniel Weisdorf, Bruce R Blazar, Jeffrey S Miller, Veronika Bachanova, Najla H El Jurdi, Brian C Betts

Blood (2023) 142 (Supplement 1): 2177.

https://doi.org/10.1182/blood-2023-173376

Published: 2023

Journal Articles

A Mouse Model of CD19 CAR - T Cell Therapy Reveals Mechanism of Cytopenia

Bartosz Grzywacz, Ashenafi Tilahun, Irena Wilson, Kevin Welk, Bruce R Blazar, Christopher A Pennell

Blood (2023) 142 (Supplement 1): 3460.

https://doi.org/10.1182/blood-2023-190175

Published: 2023

Journal Articles

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Holly Wobma, Jiayi Dong, Francesca Alvarez Calderon, Xianliang Rui, Katherine Michaelis, Bruce R Blazar, Victor Tkachev, Ulrike Gerdemann, Leslie Kean

Blood (2023) 142 (Supplement 1): 3447.

https://doi.org/10.1182/blood-2023-180218

Published: 2023

Journal Articles

IL-33 Induces Paneth Cell Production of EGF and Soluble ST2, Regulating Epithelial Regeneration after Intestinal Injury

Marco Calafiore, YA-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Chang, Suze Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan Serody, Susumu Nakae, Heth Turnquist, Johan van Es, Hans Clevers, Caroline A. Lindemans, Bruce R Blazar, Alan M. Hanash

Blood (2023) 142 (Supplement 1): 346.

https://doi.org/10.1182/blood-2023-191189

Published: 2023

Journal Articles

Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Henrike Salié, Dimitrios Athanassopoulos, Lukas Braun, Dominik Schmidt, Viktor Fetsch, Rebeka N. Javorniczky, Jenny N.H.G Ho, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian Capitini, Terry J. Fry, Thomas Blank, Bruce R Blazar, Eva-Maria Wagner Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, K. Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp Tobias Meyer, Joachim Brumberg, Andreas Mackensen, Michael von Bergwelt-Baildon, Roland Coras, Nathalie L. Albert, Laura M. Bartos, Matthias Brendel, Adrien Holzgreve, Melanie Boerries, Crystal L. Mackall, Justus Duyster, Natalie Koehler, Felix Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser

Blood (2023) 142 (Supplement 1): 100.

https://doi.org/10.1182/blood-2023-184867

Published: 2023

Journal Articles

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Blood (2023) 142 (8): 700–710.

https://doi.org/10.1182/blood.2023020035

Published: 2023

Includes: Supplemental data

Journal Articles

Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo

Blood (2023) 141 (11): 1337–1352.

https://doi.org/10.1182/blood.2022018440

Published: 2023

Includes: Supplemental data

Journal Articles

Modulating Donor T Cell Graft-Versus-Host and Graft-Versus-Tumor Reactivity By Stat6

Hope Fury, Xiaoqun Guan, Tyler Atagozli, David E. Elliot, Bruce R. Blazar, M. Nedim Ince

Blood (2022) 140 (Supplement 1): 10261–10262.

https://doi.org/10.1182/blood-2022-169405

Published: 2022

Journal Articles

ACC1 Inhibition Enhances Treg Gvhd Treatment Efficacy through Reciprocal Fatty-Acid Synthesis and Oxidative Phosphorylation Regulation

Cameron McDonald-Hyman, Ethan Aquilar, Stephanie Rhee, Fathima Mohamed, Ewaldus Compeer, Michael Dustin, Keli Lee Hippen, Bruce R. Blazar

Blood (2022) 140 (Supplement 1): 4459–4460.

https://doi.org/10.1182/blood-2022-160475

Published: 2022

Journal Articles

Different Subsets of Exhausted and Senescent-like T Cells Correlate with Response and Survival in Patients with Acute Myeloid Leukemia (AML) Undergoing Chemotherapy

Francesco Mazziotta, Luca Biavati, Sonali Parbhoo, Sayan Chowdhury, Joseph Rimando, Ivan M. Borrello, Katerina Hatzi, Bruce R. Blazar, Ivana Gojo, Leo Luznik

Blood (2022) 140 (Supplement 1): 9132–9133.

https://doi.org/10.1182/blood-2022-167107

Published: 2022

Journal Articles

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

Xianliang Rui, Francesca Alvarez Calderon, Ulrike Gerdemann, Connor McGuckin, Lorenzo Cagnin, Bruce R. Blazar, Victor Tkachev, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 871–872.

https://doi.org/10.1182/blood-2022-165745

Published: 2022

Journal Articles

Early Breakthrough T Cell Proliferation Despite CNI/MTX Prophylaxis Is a Harbinger of Acute Gvhd (AGVHD) and Is Controlled By Abatacept: Mechanism of Success of the ABA2 Agvhd Prevention Trial

Alexandre Albanese, Alal Eran, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Paula Keskula, Lorenzo Cagnin, Amelia Langston, Muna Qayed, John T. Horan, Bruce R. Blazar, Benjamin Watkins, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 274–275.

https://doi.org/10.1182/blood-2022-170693

Published: 2022

Journal Articles

Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd

Alexandre Albanese, Edward Chen, Jillian Zavistaski, Kayla Betz, Yvonne Suessmuth, Lorenzo Cagnin, Paula Keskula, Kyle Kimler, James Kaminski, Bruce R. Blazar, Benjamin Watkins, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 270–271.

https://doi.org/10.1182/blood-2022-170214

Published: 2022

Journal Articles

Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

Blood (2022) 140 (10): 1167–1181.

https://doi.org/10.1182/blood.2022016082

Published: 2022

Includes: Supplemental data

NARROW

Chronic graft-versus-host disease: unresolved complication or ancient history?

CD8 + T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia

JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 cells: Final Phase II Trial Results

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

ACC1 Inhibition Enhances Treg Gvhd Treatment Efficacy through Regulation of Mitochondrial Fusion and Elongation

Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction

JAK2/mTOR Inhibition Fails to Prevent Acute Gvhd Despite Reduced Th1/Th17 Cells: Final Phase II Trial Results

A Mouse Model of CD19 CAR - T Cell Therapy Reveals Mechanism of Cytopenia

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

IL-33 Induces Paneth Cell Production of EGF and Soluble ST2, Regulating Epithelial Regeneration after Intestinal Injury

Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo

Modulating Donor T Cell Graft-Versus-Host and Graft-Versus-Tumor Reactivity By Stat6

ACC1 Inhibition Enhances Treg Gvhd Treatment Efficacy through Reciprocal Fatty-Acid Synthesis and Oxidative Phosphorylation Regulation

Different Subsets of Exhausted and Senescent-like T Cells Correlate with Response and Survival in Patients with Acute Myeloid Leukemia (AML) Undergoing Chemotherapy

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

Early Breakthrough T Cell Proliferation Despite CNI/MTX Prophylaxis Is a Harbinger of Acute Gvhd (AGVHD) and Is Controlled By Abatacept: Mechanism of Success of the ABA2 Agvhd Prevention Trial

Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd

Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

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American Society of Hematology

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American Society of Hematology

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