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Journal Articles

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

Blood (2024) 144 (1): 46–60.

https://doi.org/10.1182/blood.2023022717

Published: 2024

Includes: Supplemental data

Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood (2024) 143 (21): 2201–2216.

https://doi.org/10.1182/blood.2023023549

Published: 2024

Includes: Supplemental data

Journal Articles

In Vivo Delivery of RNA By Lipid Nanoparticles (LNP) to Hematopoietic Stem Cells and T Cells in Humanized Mice and Non-Human Primates

Blood (2023) 142 (Supplement 1): 4818.

https://doi.org/10.1182/blood-2023-187271

Published: 2023

Journal Articles

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Holly Wobma, Jiayi Dong, Francesca Alvarez Calderon, Xianliang Rui, Katherine Michaelis, Bruce R Blazar, Victor Tkachev, Ulrike Gerdemann, Leslie Kean

Blood (2023) 142 (Supplement 1): 3447.

https://doi.org/10.1182/blood-2023-180218

Published: 2023

Journal Articles

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Francesca Alvarez Calderon, Ryan A Fleming, Lev Gorfinkel, Katherine Michaelis, Xianliang Rui, James Kaminski, Dana Bonin, Anick Mallette, Katherine Brodeur, Heber Domingues, Jennifer Lane, Victor Tkachev, Leslie Kean, Ulrike Gerdemann

Blood (2023) 142 (Supplement 1): 2087.

https://doi.org/10.1182/blood-2023-187499

Published: 2023

Journal Articles

Targeting CNS Lymphoma with Intravenous Axicabtagene Ciloleucel: Evidence for Transcriptional Evolution Towards a Prominent Interferon Signature in CAR-T Cells Trafficking to the Tumor Site

Ulrike Gerdemann, James Kaminski, Alexandre Albanese, Paula Keskula, Lorenzo Cagnin, Kayla Betz, Jillian Zavistaski, Ryan A Fleming, Caroline Falvey, Riemke Bouvier, Julia Jones, Soumya Poddar, Mike Mattie, Ugonma Chukwueke, Alexandra Torres, Caron A. Jacobson, Lakshmi Nayak, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 408–409.

https://doi.org/10.1182/blood-2022-166645

Published: 2022

Journal Articles

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

Ulrike Gerdemann, James Kaminski, Ryan A Fleming, Victor Tkachev, Francesca Alvarez Calderon, Connor McGuckin, Xianliang Rui, Jennifer Lane, Alex K. Shalek, Leslie Kean

Blood (2022) 140 (Supplement 1): 1167–1168.

https://doi.org/10.1182/blood-2022-169435

Published: 2022

Journal Articles

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

Xianliang Rui, Francesca Alvarez Calderon, Ulrike Gerdemann, Connor McGuckin, Lorenzo Cagnin, Bruce R. Blazar, Victor Tkachev, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 871–872.

https://doi.org/10.1182/blood-2022-165745

Published: 2022

Journal Articles

A Pilot Study of Axicabtagene Ciloleucel (axi-cel) for the Treatment of Relapsed/Refractory Primary and Secondary Central Nervous System Lymphoma (CNSL)

Blood (2022) 140 (Supplement 1): 1060–1061.

https://doi.org/10.1182/blood-2022-165256

Published: 2022

Journal Articles

Targeted Deletion of Activated T Cells with a Single Dose of Anti-CD137-Antibody Drug Conjugate Protects Against Acute Gvhd (AGVHD) and Promotes Tolerogenic T Cell Reconstitution after Haplo-Identical Hematopoietic Stem Cell Transplantation (HSCT)

Ulrike Gerdemann, Jennifer Lane, Kyle Kimler, Leanne Lanieri, Lisa Olson, Leslie S. Kean, Victor Tkachev

Blood (2022) 140 (Supplement 1): 1568–1569.

https://doi.org/10.1182/blood-2022-166462

Published: 2022

Journal Articles

Uncovering CD4 + T-cell exhaustion in B-ALL

Ulrike Gerdemann, Francesca Alvarez-Calderon

Blood (2022) 140 (4): 294–296.

https://doi.org/10.1182/blood.2022016597

Published: 2022

Journal Articles

Immunotherapy for Lymphoma Using T Cells Targeting Multiple Tumor Associated Antigens

Ann Leen, PhD, Ifigeneia Tzannou, MD, Munu Bilgi, Hao Liu, PhD, Juan F Vera, MD, Ulrike Gerdemann, MD, Rammurti T Kamble, MD, Carlos A. Ramos, MD, Bambi Grilley, RPh, Adrian P. Gee, PhD, Catherine M. Bollard, MD, Malcolm K. Brenner, MD PhD, Helen E. Heslop, MD, Cliona M. Rooney, PhD, George Carrum, MD

Blood (2015) 126 (23): 186.

https://doi.org/10.1182/blood.V126.23.186.186

Published: 2015

Journal Articles

Adoptively-Transferred EBV-Specific T Cells to Prevent or Treat EBV-Related Lymphoproliferative Disease in Allogeneic HSCT Recipients - a Single Center Experience Spanning 22 Years

Ifigeneia Tzannou, MD, Bilal Omer, MD, Anastasia Papadopoulou, PhD, Ulrike Gerdemann, MD, Colton Smith, PhD, Adrian P. Gee, PhD, Bambi J Grilley, Malcolm K. Brenner, MB, PhD FRCP, FRCPath, Catherine M. Bollard, MD, Ann M. Leen, PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD

Blood (2015) 126 (23): 1926.

https://doi.org/10.1182/blood.V126.23.1926.1926

Published: 2015

Journal Articles

Safety and Clinical Efficacy Of Rapidly-Generated Virus-Specific T Cells With Activity Against Adv, EBV, CMV, HHV6 and BK Virus Administered After Allogeneic Hematopoietic Stem Cell Transplant

Anastasia Papadopoulou, Usha L Katari, Ulrike Gerdemann, Caridad Martinez, MD, Kathryn Leung, George Carrum, Adrian P. Gee, PhD, Juan F Vera, Robert A. Krance, MD, Malcolm K. Brenner, Cliona M Rooney, PhD, Helen E. Heslop, MD, Ann Leen, PhD

Blood (2013) 122 (21): 148.

https://doi.org/10.1182/blood.V122.21.148.148

Published: 2013

Journal Articles

Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation

Ulrike Gerdemann, Laura Keukens, Jacqueline M. Keirnan, Usha L. Katari, Chinh T. Q. Nguyen, Anne P. de Pagter, Carlos A. Ramos, Alana Kennedy-Nasser, Stephen M. Gottschalk, Helen E. Heslop, Malcolm K. Brenner, Cliona M. Rooney, Ann M. Leen

Blood (2013) 121 (1): 207–218.

https://doi.org/10.1182/blood-2012-05-430413

Published: 2013

Includes: Supplemental data

Journal Articles

Safety and Clinical Efficacy of Rapidly-Generated Trivirus-Directed T Cells After Allogeneic Hematopoietic Stem Cell Transplant

Ulrike Gerdemann, MD, Usha L Katari, Jacqueline Keirnan, John A. Craddock, M.D., Janet Salinas, Hao Liu, PhD, Caridad Martinez, MD, Alana Kennedy-Nasser, MD, Kathryn Leung, MD, Stephen Gottschalk, MD, Adrian P. Gee, PhD, Robert A. Krance, MD, Malcolm K. Brenner, MD, PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Ann M. Leen, PhD

Blood (2012) 120 (21): 223.

https://doi.org/10.1182/blood.V120.21.223.223

Published: 2012

Journal Articles

Human Papillomavirus Type 16 (HPV16) E6/E7-Specific Cytotoxic T Lymphocytes (CTLs) for Immunotherapy of HPV-Associated Malignancies

Carlos A. Ramos, MD, Neeharika Narala, MSc, Ann M. Leen, PhD, Ulrike Gerdemann, MD, Matthew L. Anderson, MD, PhD, Erich M. Sturgis, MD, MPH, Barbara Savoldo, MD, PhD, Helen E. Heslop, MD, Malcolm K. Brenner, MD, PhD, Cliona M. Rooney, PhD

Blood (2011) 118 (21): 1913.

https://doi.org/10.1182/blood.V118.21.1913.1913

Published: 2011

Journal Articles

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

Fabian Zohren, MD, Maria R Imperato, Anurathapan Usanarat, MD, David M Spencer, PhD, Helen E. Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Ann M. Leen, PhD, Juan F Vera, MD, Ulrike Gerdemann, MD

Blood (2011) 118 (21): 644.

https://doi.org/10.1182/blood.V118.21.644.644

Published: 2011

Journal Articles

The Lymphoblastic Leukemia Gene 1 (Lyl1) Regulates Lymphoid Specification and Maintenance of Early T Lineage Progenitors

Fabian Zohren, MD, George Souroullas, PhD, Min Luo, Ph.D., Ulrike Gerdemann, MD, Nicola K Wilson, Berthold Göttgens, DPhil, Georgi L. Lukov, MD, PhD, Margaret Goodell, Ph.D.

Blood (2011) 118 (21): 548.

https://doi.org/10.1182/blood.V118.21.548.548

Published: 2011

Journal Articles

Improving T Cell Therapy for Relapsed EBV-Negative Hodgkin's Lymphoma by Targeting Upregulated MAGE-A4

Conrad Russell Y. Cruz, MD, Ulrike Gerdemann, MD, Ann M. Leen, PhD, Jessica A. Shafer, MD, Stephanie Ku, BS, Benjamin Tzou, BS, Terzah M. Horton, MD, PhD, Amanda Copeland, MSN, Anas Younes, MD, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Catherine M. Bollard, MD

Blood (2011) 118 (21): 1658.

https://doi.org/10.1182/blood.V118.21.1658.1658

Published: 2011

NARROW

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

In Vivo Delivery of RNA By Lipid Nanoparticles (LNP) to Hematopoietic Stem Cells and T Cells in Humanized Mice and Non-Human Primates

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Targeting CNS Lymphoma with Intravenous Axicabtagene Ciloleucel: Evidence for Transcriptional Evolution Towards a Prominent Interferon Signature in CAR-T Cells Trafficking to the Tumor Site

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

A Pilot Study of Axicabtagene Ciloleucel (axi-cel) for the Treatment of Relapsed/Refractory Primary and Secondary Central Nervous System Lymphoma (CNSL)

Targeted Deletion of Activated T Cells with a Single Dose of Anti-CD137-Antibody Drug Conjugate Protects Against Acute Gvhd (AGVHD) and Promotes Tolerogenic T Cell Reconstitution after Haplo-Identical Hematopoietic Stem Cell Transplantation (HSCT)

Uncovering CD4 + T-cell exhaustion in B-ALL

Immunotherapy for Lymphoma Using T Cells Targeting Multiple Tumor Associated Antigens

Adoptively-Transferred EBV-Specific T Cells to Prevent or Treat EBV-Related Lymphoproliferative Disease in Allogeneic HSCT Recipients - a Single Center Experience Spanning 22 Years

Safety and Clinical Efficacy Of Rapidly-Generated Virus-Specific T Cells With Activity Against Adv, EBV, CMV, HHV6 and BK Virus Administered After Allogeneic Hematopoietic Stem Cell Transplant

Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation

Safety and Clinical Efficacy of Rapidly-Generated Trivirus-Directed T Cells After Allogeneic Hematopoietic Stem Cell Transplant

Human Papillomavirus Type 16 (HPV16) E6/E7-Specific Cytotoxic T Lymphocytes (CTLs) for Immunotherapy of HPV-Associated Malignancies

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

The Lymphoblastic Leukemia Gene 1 (Lyl1) Regulates Lymphoid Specification and Maintenance of Early T Lineage Progenitors

Improving T Cell Therapy for Relapsed EBV-Negative Hodgkin's Lymphoma by Targeting Upregulated MAGE-A4

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American Society of Hematology

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