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Journal Articles

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

Blood (2024) 144 (1): 46–60.

https://doi.org/10.1182/blood.2023022717

Published: 2024

Includes: Supplemental data

Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood (2024) 143 (21): 2201–2216.

https://doi.org/10.1182/blood.2023023549

Published: 2024

Includes: Supplemental data

Journal Articles

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Holly Wobma, Jiayi Dong, Francesca Alvarez Calderon, Xianliang Rui, Katherine Michaelis, Bruce R Blazar, Victor Tkachev, Ulrike Gerdemann, Leslie Kean

Blood (2023) 142 (Supplement 1): 3447.

https://doi.org/10.1182/blood-2023-180218

Published: 2023

Journal Articles

Highly Multiplexed Immunohistochemistry Can Predict Steroid Refractory Gastrointestinal (GI) Acute Gvhd at the Time of Endoscopy

Sara Rosenbaum, Nathalie Fiaschi, Wei Keat Lim, Sumreen Jalal, Kaitlyn Gayvert, Paula Keskula, Alexandre Albanese, Victor Tkachev, Jeffrey Goldsmith, Georgios D Kalliolias, Matthew Sleeman, Leslie Kean

Blood (2023) 142 (Supplement 1): 478.

https://doi.org/10.1182/blood-2023-189766

Published: 2023

Journal Articles

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Francesca Alvarez Calderon, Ryan A Fleming, Lev Gorfinkel, Katherine Michaelis, Xianliang Rui, James Kaminski, Dana Bonin, Anick Mallette, Katherine Brodeur, Heber Domingues, Jennifer Lane, Victor Tkachev, Leslie Kean, Ulrike Gerdemann

Blood (2023) 142 (Supplement 1): 2087.

https://doi.org/10.1182/blood-2023-187499

Published: 2023

Journal Articles

Engineering T cells to suppress acute GVHD and leukemia relapse after allogeneic hematopoietic stem cell transplantation

Feiyan Mo, Norihiro Watanabe, Kayleigh I. Omdahl, Phillip M. Burkhardt, Xiaoyun Ding, Eiko Hayase, Angela Panoskaltsis-Mortari, Robert R. Jenq, Helen E. Heslop, Leslie S. Kean, Malcolm K. Brenner, Victor Tkachev, Maksim Mamonkin

Blood (2023) 141 (10): 1194–1208.

https://doi.org/10.1182/blood.2022016052

Published: 2023

Includes: Supplemental data

Journal Articles

Targeted Deletion of Activated T Cells with a Single Dose of Anti-CD137-Antibody Drug Conjugate Protects Against Acute Gvhd (AGVHD) and Promotes Tolerogenic T Cell Reconstitution after Haplo-Identical Hematopoietic Stem Cell Transplantation (HSCT)

Ulrike Gerdemann, Jennifer Lane, Kyle Kimler, Leanne Lanieri, Lisa Olson, Leslie S. Kean, Victor Tkachev

Blood (2022) 140 (Supplement 1): 1568–1569.

https://doi.org/10.1182/blood-2022-166462

Published: 2022

Journal Articles

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

Xianliang Rui, Francesca Alvarez Calderon, Ulrike Gerdemann, Connor McGuckin, Lorenzo Cagnin, Bruce R. Blazar, Victor Tkachev, Leslie S. Kean

Blood (2022) 140 (Supplement 1): 871–872.

https://doi.org/10.1182/blood-2022-165745

Published: 2022

Journal Articles

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

Ulrike Gerdemann, James Kaminski, Ryan A Fleming, Victor Tkachev, Francesca Alvarez Calderon, Connor McGuckin, Xianliang Rui, Jennifer Lane, Alex K. Shalek, Leslie Kean

Blood (2022) 140 (Supplement 1): 1167–1168.

https://doi.org/10.1182/blood-2022-169435

Published: 2022

Journal Articles

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

Ben Watkins, MD, James Kaminski, Muna Qayed, MDMSc, Kayla Betz, BS, Yvonne Suessmuth, PhD, Brandi Bratrude, Alison Yu, PhD, Victor Tkachev, PhD, Kathryn Pellegrini, Steven Bosinger, PhD, Bruce R. Blazar, MD, John T. Horan, MDMPH, Amelia Langston, MD, Leslie Kean, MD PhD

Blood (2020) 136 (Supplement 1): 38–39.

https://doi.org/10.1182/blood-2020-139488

Published: 2020

Journal Articles

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Scott N Furlan, MD, Christina Lopez, PhD, Victor Tkachev, PhD, Kayla Betz, Daniel J Hunt, James Hibbard, PhD, Bruce R. Blazar, MD, Cole Trapnell, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2049.

https://doi.org/10.1182/blood-2018-99-120254

Published: 2018

Journal Articles

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Victor Tkachev, PhD, Frank Kuhnert, PhD, Scott N Furlan, MD, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Judith M Carlson, BS, Agne Taraseviciute, MD PhD, Angela Panoskaltsis-Mortari, PhD, Virginia Hoglund, Kayla Betz, Alison Yu, PhD, Bruce R. Blazar, MD, Steve Carpenter, MD PhD, Olivier Harari, MD PhD, Gavin Thurston, PhD, Ivan Maillard, MD PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 2027.

https://doi.org/10.1182/blood-2018-99-110030

Published: 2018

Journal Articles

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N Furlan, MD, E. Lake Potter, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Agne Taraseviciute, MD PhD, Judith M Carlson, BS, Kayla Betz, Alison Yu, PhD, Michelle Hoffman, MS, Audrey Baldessari, DVM, Sarah Herrin, Joe Olvera, Chad Littlewood, Christopher English, Bruce R. Blazar, MD, Mario Roederer, PhD, Leslie Kean, MD PhD

Blood (2018) 132 (Supplement 1): 805.

https://doi.org/10.1182/blood-2018-99-113652

Published: 2018

Journal Articles

Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

Blood (2017) 130 (Supplement 1): 694.

https://doi.org/10.1182/blood.V130.Suppl_1.694.694

Published: 2017

Journal Articles

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Betty Zheng, MD, Daniel Hunt, Angela Panoskaltsis-Mortari, PhD, Kayla Betz, Melanie Brown, Katie Zeleski, Alison Yu, PhD, Bruce R. Blazar, MD, Duncan Casson, Ian Kirby, Phil Bland-Ward, Leslie Kean, MD PhD

Blood (2016) 128 (22): 3341.

https://doi.org/10.1182/blood.V128.22.3341.3341

Published: 2016

Journal Articles

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Scott N. Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J. Hunt, John B. Schell, Katie Zeleski, Alison Yu, Cynthia R. Giver, Edmund K. Waller, Jeffrey S. Miller, Bruce R. Blazar, Leslie S. Kean

Blood (2016) 128 (21): 2568–2579.

https://doi.org/10.1182/blood-2016-07-726547

Published: 2016

Includes: Supplemental data

Journal Articles

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

Scott N. Furlan, MD, Victor Tkachev, PhD, Ben Watkins, MD, Kayla Betz, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 1878.

https://doi.org/10.1182/blood.V126.23.1878.1878

Published: 2015

Journal Articles

T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease

Victor Tkachev, PhD, Scott N. Furlan, MD, Ben Watkins, MD, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie Kean, MD PhD

Blood (2015) 126 (23): 3079.

https://doi.org/10.1182/blood.V126.23.3079.3079

Published: 2015

Journal Articles

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Blood (2015) 125 (20): 3183–3192.

https://doi.org/10.1182/blood-2014-10-606830

Published: 2015

Includes: Supplemental data

Journal Articles

Regulation of Immune Responses during Acute GvHD Via the IL-33/ST2 Axis

Blood (2014) 124 (21): 844.

https://doi.org/10.1182/blood.V124.21.844.844

Published: 2014

NARROW

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Cyclosporine and Voclosporin Resistant Immune Effector Cells to Improve Outcomes after Stem Cell Transplantation

Highly Multiplexed Immunohistochemistry Can Predict Steroid Refractory Gastrointestinal (GI) Acute Gvhd at the Time of Endoscopy

Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model

Engineering T cells to suppress acute GVHD and leukemia relapse after allogeneic hematopoietic stem cell transplantation

Targeted Deletion of Activated T Cells with a Single Dose of Anti-CD137-Antibody Drug Conjugate Protects Against Acute Gvhd (AGVHD) and Promotes Tolerogenic T Cell Reconstitution after Haplo-Identical Hematopoietic Stem Cell Transplantation (HSCT)

A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

Predicting Immune Pathology after Hematopoietic Stem Cell Transplant with Transcriptomics: Naïve CD4 T Cell Expansion at Day 100 Predicts Patients with De Novo Chronic Gvhd

IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Uncovering the Molecular Signature of Pathogenic Tissue-Infiltrating T Cells during Acute Graft-Versus-Host Disease

Modeling and Understanding the Biology of Transplant-Mediated HIV Cure in a Non-Human Primate Model

Striking Clinical, Molecular and Immunological Outcomes in Non-Human Primate Hematopoietic Stem Cell Transplantation Using a Novel OX40L Blockade Agent, KY1005, Combined with Rapamycin

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Th17/Th22 Cells Mediate Breakthrough Graft-Versus-Host-Disease

T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Regulation of Immune Responses during Acute GvHD Via the IL-33/ST2 Axis

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American Society of Hematology

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American Society of Hematology

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