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Alex K. Shalek
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Journal Articles

B-cell–directed CAR T-cell therapy activates CD8 + cytotoxic CAR neg bystander T cells in patients and nonhuman primates

James Kaminski, Ryan A. Fleming, Francesca Alvarez-Calderon, Marlana B. Winschel, Connor McGuckin, Emily E. Ho, Fay Eng, Xianliang Rui, Paula Keskula, Lorenzo Cagnin, Joanne Charles, Jillian Zavistaski, Steven P. Margossian, Malika A. Kapadia, James B. Rottman, Jennifer Lane, Susanne H. C. Baumeister, Victor Tkachev, Alex K. Shalek, Leslie S. Kean, Ulrike Gerdemann
Journal: Blood
Blood (2024) 144 (1): 46–60.
https://doi.org/10.1182/blood.2023022717
Published: 2024
Includes: Supplemental data
Journal Articles

Cell Mass and Stiffness As Integrative Biomarkers of Cell State in Mantle Cell Lymphoma

Lydie Debaize, Ye Zhang, Adam Langenbucher, Huiyun Liu, Michelle Ramseier, Nolawit Mulugeta, Nezha Senhaji, Robert A. Redd, Martin J. Aryee, Alex K. Shalek, David M. Weinstock, Scott R. Manalis, Mark A. Murakami
Journal: Blood
Blood (2022) 140 (Supplement 1): 3581–3582.
https://doi.org/10.1182/blood-2022-169700
Published: 2022
Journal Articles

CAR-T Cell Infusion Results in Activation of CD160+/NKG2D+/CCL5+ Non-CAR CD8+ Cytotoxic 'Bystander' T Cells in Both Non-Human Primates (NHP) and Patients Receiving B-Cell-Directed CAR-Ts

Ulrike Gerdemann, James Kaminski, Ryan A Fleming, Victor Tkachev, Francesca Alvarez Calderon, Connor McGuckin, Xianliang Rui, Jennifer Lane, Alex K. Shalek, Leslie Kean
Journal: Blood
Blood (2022) 140 (Supplement 1): 1167–1168.
https://doi.org/10.1182/blood-2022-169435
Published: 2022
Journal Articles

Mechanisms of Leukemia Stem Cell Plasticity Revealed By Single Cell Analysis

R. Grant Rowe, George Q. Daley, MD PhD, Trista E. North, PhD, William Marion, Yana Pikman, MD, Marian H. Harris, MD PhD, Vivian Morris, Edroaldo Lummertz da rocha, PhD, Alex K. Shalek, PhD, Travis Hughes, Prerana Sensharma, Dahai Wang, Patricia Sousa, Shannan Ho Sui, Sergey Naumenko, Renan Vinicius Da Silva
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-135998
Published: 2020
Journal Articles

Single-Cell RNA-Seq Reveals AML Cellular Hierarchies Relevant to Clinical Outcomes and Immunity

Peter Van Galen, PhD, Volker Hovestadt, PhD, Marc Wadsworth II, Travis Hughes, Gabriel Kenneth Griffin, MD, Julia A. Verga, Jason Stephansky, Timothy J. Pastika, Jennifer Lombardi Story, Geraldine S. Pinkus, MD, Olga Pozdnyakova, MD PhD, Ilene Galinsky, Richard M. Stone, MD, Timothy A. Graubert, MD, Alex K. Shalek, PhD, Jon C. Aster, MD PhD, Andrew A. Lane, MD PhD, Bradley E. Bernstein, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 542.
https://doi.org/10.1182/blood-2018-99-113502
Published: 2018
Journal Articles

Linking Biophysical and Transcriptional Profiles of In Vivo -Treated Human Leukemias on a Single-Cell Level Uniquely Resolves Subpopulations of Response

Mark A. Murakami, MDMA,MMSc, Mark M Stevens, PhD, Robert J Kimmerling, PhD, Alejandro J Gupta, BS, Huiyun Liu, Sanjay M. Prakadan, AB, Alex K. Shalek, PhD, Scott R. Manalis, PhD, David M. Weinstock, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3987.
https://doi.org/10.1182/blood.V130.Suppl_1.3987.3987
Published: 2017
Journal Articles

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL

Lili Wang, Alex K. Shalek, Mike Lawrence, Ruihua Ding, Jellert T. Gaublomme, Nathalie Pochet, Petar Stojanov, Carrie Sougnez, Sachet A. Shukla, Kristen E. Stevenson, Wandi Zhang, Jessica Wong, Quinlan L. Sievers, Bryan T. MacDonald, Alexander R. Vartanov, Natalie R. Goldstein, Donna Neuberg, Xi He, Eric Lander, Nir Hacohen, Aviv Regev, Gad Getz, Jennifer R. Brown, Hongkun Park, Catherine J. Wu
Journal: Blood
Blood (2014) 124 (7): 1089–1098.
https://doi.org/10.1182/blood-2014-01-552067
Published: 2014
Includes: Supplemental data
Journal Articles

Somatic Mutation As a Mechanism of Wnt/β-Catenin Pathway Activation in CLL

Lili Wang, M.D., Ph.D., Alex K Shalek, Ph.D., Jellert Gaublomme, Michael Lawrence, Ph.D., Kristen E. Stevenson, MS, Donna S. Neuberg, ScD, Nir Hacohen, PhD, Gad Getz, Ph.D., Jennifer R. Brown, MD, PhD, Hongkun Park, Ph.D., Catherine J. Wu, MD
Journal: Blood
Blood (2012) 120 (21): 559.
https://doi.org/10.1182/blood.V120.21.559.559
Published: 2012
Journal Articles

Sensitivity to Wnt Pathway Inhibition in CLL Is Associated with Specific Gene Expression Signatures

Lili Wang, Alex K Shalek, Jellert Gaublomme, Nir Yosef, Jennifer R Brown, MD, PhD, Donna Neuberg, ScD, Nir Hacohen, Hongkun Park, Catherine J Wu, MD
Journal: Blood
Blood (2011) 118 (21): 801.
https://doi.org/10.1182/blood.V118.21.801.801
Published: 2011