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David M. Weinstock
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Journal Articles

Asciminib plus dasatinib and prednisone for Philadelphia chromosome-positive acute leukemia

Clinical Trials & Observations
Marlise R. Luskin, Mark Alan Murakami, Julia H. Keating, Yael Flamand, Eric S Winer, Jacqueline S. Garcia, Maximilian Stahl, Richard M. Stone, Martha Wadleigh, Stella Louise Jaeckle, Ella Hagopian, David M. Weinstock, Jessica Liegel, Malgorzata McMasters, Eunice S Wang, Wendy Stock, Daniel J DeAngelo
Journal: Blood
Blood blood.2024025800.
https://doi.org/10.1182/blood.2024025800
Published: 2024
Includes: Supplemental data
Journal Articles

Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma

Alyssa Bouska, Weiwei Zhang, Sunandini Sharma, Harald Holte, Ab Rauf Shah, Waseem Gul Lone, Luca Vincenzo Cappelli, Danilo Fiore, Qiang Gong, Tayla Heavican-Foral, Jeffrey Cannatella, Catalina Amador, Aiza Arif, Lynette Smith, Soon Thye Lim, Choon Kiat Ong, Andrew L. Feldman, Ming-Qing Du, Laurence de Leval, Timothy C. Greiner, Kai Fu, Gunhild Trøen, Daniel Vodak, Sigve Nakken, Jan Delabie, David M. Weinstock, Stefano A. Pileri, Antonella Laginestra, Kyeongjin Kim, Utpal Pajvani, Julie M. Vose, Dennis D Weisenburger, Sandeep Dave, Giorgio Inghirami, Wing C. Chan, Javeed Iqbal
Journal: Blood
Blood (2023) 142 (Supplement 1): 2993.
https://doi.org/10.1182/blood-2023-186530
Published: 2023
Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

Cell Mass and Stiffness As Integrative Biomarkers of Cell State in Mantle Cell Lymphoma

Lydie Debaize, Ye Zhang, Adam Langenbucher, Huiyun Liu, Michelle Ramseier, Nolawit Mulugeta, Nezha Senhaji, Robert A. Redd, Martin J. Aryee, Alex K. Shalek, David M. Weinstock, Scott R. Manalis, Mark A. Murakami
Journal: Blood
Blood (2022) 140 (Supplement 1): 3581–3582.
https://doi.org/10.1182/blood-2022-169700
Published: 2022
Journal Articles

Cellular Plasticity As Mechanisms to Escape from NOTCH1-Inhibition in T-ALL

Valeriya Dimitrova, Noori Sotudeh, Birgit Knoechel, Jens G. Lohr, Anna Montanaro, Sayalee V. Potdar, Julia Frede, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Jon C. Aster, David M Weinstock, Anthony G. Letai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3461–3462.
https://doi.org/10.1182/blood-2022-170319
Published: 2022
Journal Articles

KLRG1 Depletion Is a Novel Therapeutic Strategy for Patients with Mature T and NK/T-Cell Lymphomas

Bimarzhan Assatova, Christopher Trevisani, Robert Willim, Jessica Duffy, Abner Louissaint, Jr., Won-Seog Kim, David J Feith, Thomas Loughran, Jr., Foster Powers, Elizabeth A Morgan, Lei Yang, Brandy Pinckney, Garrett Haskett, Matthew J Cotton, Andrew Crabbe, Jessica Beth Ziemba, Ian Brain, Tayla B. Heavican-Foral, Nora Scanlan, Gail Newton, Jaehyuk Choi, Jeffrey A Barnes, Patrick Connor Johnson, Eric D Jacobsen, Steven Greenberg, David M. Weinstock, Salvia Jain
Journal: Blood
Blood (2022) 140 (Supplement 1): 2253–2255.
https://doi.org/10.1182/blood-2022-162583
Published: 2022
Journal Articles

TP63 Fusions Drive Enhancer Rewiring, Lymphomagenesis, and Dependence on EZH2

Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Tayla B. Heavican-Foral, Huiyun Liu, Geoffrey M. Nelson, Lu Yang, Renee Chen, Marcus Kenneth Jones, Ran Xu, Ajit Johnson Nirmal, Salvia Jain, Catharine Leahy, Kristen Lynn Jones, Kristen E. Stevenson, Wenchao Wu, Abner Louissaint, Jr., Lydie Debaize, Wing C. Chan, Shannan Ho Sui, Samuel Ng, Andrew L. Feldman, Matthew Meyerson, Karen Adelman, chun-Wei David Chen, Myles Brown, David M. Weinstock
Journal: Blood
Blood (2022) 140 (Supplement 1): 1696–1697.
https://doi.org/10.1182/blood-2022-163368
Published: 2022
Journal Articles

Combinatorial Effects of BH3 Mimetics and CAR T Cells Targeting T-Cell Lymphomas

Tayla B. Heavican-Foral, Felix Korell, Irene Scarfò, Harrison Silva, Allen Basanthakumar, Foster Powers, David M. Weinstock, Marcela V. Maus, Birgit Knoechel
Journal: Blood
Blood (2022) 140 (Supplement 1): 499–500.
https://doi.org/10.1182/blood-2022-159647
Published: 2022
Journal Articles

Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1

Wenchao Wu, Geoffrey M. Nelson, Raphael Koch, Katherine A. Donovan, Radosław P. Nowak, Tayla B. Heavican-Foral, Ajit J. Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E. Stevenson, Marcus Kenneth Jones, Samuel Y. Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L. Donaldson, Patrick R. Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S. Fischer, Karen Adelman, David M. Weinstock
Journal: Blood
Blood (2022) 139 (13): 2024–2037.
https://doi.org/10.1182/blood.2021014701
Published: 2022
Includes: Supplemental data
Journal Articles

A phase 2 biomarker-driven study of ruxolitinib demonstrates effectiveness of JAK/STAT targeting in T-cell lymphomas

Clinical Trials & Observations
Alison J. Moskowitz, Paola Ghione, Eric Jacobsen, Jia Ruan, Jonathan H. Schatz, Sarah Noor, Patricia Myskowski, Santosha Vardhana, Nivetha Ganesan, Helen Hancock, Theresa Davey, Leslie Perez, Sunyoung Ryu, Alayna Santarosa, Jack Dowd, Obadi Obadi, Lauren Pomerantz, Nancy Yi, Samia Sohail, Natasha Galasso, Rachel Neuman, Brielle Liotta, William Blouin, Jeeyeon Baik, Mark B. Geyer, Ariela Noy, David Straus, Priyadarshini Kumar, Ahmet Dogan, Travis Hollmann, Esther Drill, Jurgen Rademaker, Heiko Schoder, Giorgio Inghirami, David M. Weinstock, Steven M. Horwitz
Journal: Blood
Blood (2021) 138 (26): 2828–2837.
https://doi.org/10.1182/blood.2021013379
Published: 2021
Includes: Supplemental data
Journal Articles

Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway

Katie Lee, Mark G. Evans, Lei Yang, Spencer Ng, Caroline Snowden, Michael Khodadoust, Ryanne A. Brown, Nicholas A. Trum, Christiane Querfeld, Linda T. Doan, Jinming Song, Hailing Zhang, Alejandro A. Gru, Gary S. Wood, David A. Wada, Vignesh Shanmugam, Paul L. Haun, Jon C. Aster, Lyn M. Duncan, Joan Guitart, David M. Weinstock, Valentina Nardi, Jaehyuk Choi
Journal: Blood
Blood (2021) 138 (23): 2435–2440.
https://doi.org/10.1182/blood.2021012536
Published: 2021
Includes: Supplemental data
Journal Articles

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

Jaewoong Lee, Mark E. Robinson, Ning Ma, Kohei Kume, Dewan Artadji, Teresa Sadras, Kadriye Nehir Cosgun, Huimin Geng, Elisabeth M. Paietta, Maike Buchner, Nagarajan Vaidehi, David M. Weinstock, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 355.
https://doi.org/10.1182/blood-2021-149189
Published: 2021
Journal Articles

Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

Jaewoong Lee, Mark E. Robinson, Ning Ma, Teresa Sadras, Kadriye Nehir Cosgun, Lai N. Chan, Kohei Kume, Andrei Thomas-Tikhonenko, David M. Weinstock, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 868.
https://doi.org/10.1182/blood-2021-149646
Published: 2021
Journal Articles

Maturity State and MCL-1 Dependence Predetermines Response to NOTCH1 Inhibition in T-ALL

Valeriya Dimitrova, Noori Sotudeh, Anna Montanaro, Huiyoung Yun, Sayalee V. Potdar, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Antonis Kokkalis, Jake A. Kloeber, Julia Frede, Johannes M Waldschmidt, Anthony G. Letai, David M. Weinstock, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 138 (Supplement 1): 3484.
https://doi.org/10.1182/blood-2021-153829
Published: 2021
Journal Articles

Trial-in-Progress: Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma (NCT#03269669): SWOG S1608

Paul M. Barr, Hongli Li, Brian K. Link, Christopher R. Flowers, Richard Burack, Heiko Schöder, Michael L. Leblanc, Oliver Weigert, Alex F. Herrera, David M. Weinstock, John P. Leonard, Brad S. Kahl, Sonali M. Smith, Jonathan W. Friedberg
Journal: Blood
Blood (2021) 138 (Supplement 1): 2425.
https://doi.org/10.1182/blood-2021-146182
Published: 2021
Journal Articles

Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Lai N. Chan, Mark A. Murakami, Christian Hurtz, Kohei Kume, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Shai Izraeli, David M. Weinstock, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 616.
https://doi.org/10.1182/blood-2021-149773
Published: 2021
Journal Articles

Male-Biased Spliceosome Mutations in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Impair pDC Activation and Apoptosis

Katsuhiro Togami, MDPhD, Sun Sook Chung, PhD, Vikas Madan, PhD, Christopher M. Kenyon, BS, Lucia Cabal-Hierro, PhD, Justin Taylor, MD, Sunhee Kim, MD, Gabriel K Griffin, MD, Mahmoud Ghandi, Jia Li, PhD, Yvonne Y. Li, PhD, Fanny Angelot-Delletre, PhD, Sabeha Biichle, Michael Seiler, Silvia Buonamici, PhD, Scott B Lovitch, MDPhD, Abner Louissaint, Jr., MD PhD, Elizabeth A Morgan, MD, Fabrice Jardin, MD PhD, Pier Paolo Piccaluga, MD PhD, David M. Weinstock, MD, Peter S. Hammerman, MD PhD, Henry Yang, PhD, Marina Konopleva, MD PhD, Naveen Pemmaraju, MD, Francine Garnache-Ottou, PhD, Omar Abdel-Wahab, MD, H. Phillip Koeffler, MD, Andrew A Lane, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-137727
Published: 2020
Journal Articles

Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions

Brief Report
Noriaki Yoshida, Kay Shigemori, Nicholas Donaldson, Christopher Trevisani, Nicolas A. Cordero, Kristen E. Stevenson, Xia Bu, Fumiko Arakawa, Mai Takeuchi, Koichi Ohshima, Akinori Yoda, Samuel Y. Ng, David M. Weinstock
Journal: Blood
Blood (2020) 135 (17): 1467–1471.
https://doi.org/10.1182/blood.2019001815
Published: 2020
Includes: Supplemental data
Journal Articles

Aberrant Cathepsin S Induces a Supportive Immune Microenvironment in Follicular Lymphoma

Johannes Adrian Hildebrand, MSc, BSc, Deepak Bararia, Sebastian Stolz, Sarah Haebe, MD, Stefan Alig, Michael Bartoschek, Michael Boesl, Alessandro Pastore, Erik Gaitzsch, Michael Heide, Vindi Jurinovic, MSc, Monika Szczepanowski, Wolfram Klapper, Abner Louissaint, Jr., MD PhD, Christina Ludwig, Sebastian Bultmann, Heinrich Leonhardt, Sebastian Eustermann, Karl-Peter Hopfner, Wolfgang Hiddemann, MD PhD, Michael von Bergwelt, Christian Steidl, MD, Robert Kridel, MDMPH,PhD, David M Weinstock, Marc Schmidt-Supprian, Menyhárt B Sárosi, Verena Passerini, Josef Mautner, Oliver Weigert
Journal: Blood
Blood (2019) 134 (Supplement_1): 657.
https://doi.org/10.1182/blood-2019-122663
Published: 2019
Journal Articles

High Accuracy, Low-Cost Transcriptional Diagnostic to Transform Lymphoma Care in Low- and Middle-Income Countries

Edward Briercheck, MD, Fabiola Valvert, MD, Elizabeth Solorzano, MSc, Oscar Silva, MD PhD, Maneka Puligandla, MS, Marcos Mauricio Siliézar Tala, MD, Timothy Guyon, MSc, Samuel L. Dixon, BS, Robert Terbrueggen, PhD, Yasodha Natkunam, MD PhD, Kristen E. Stevenson, MS, David M Weinstock
Journal: Blood
Blood (2019) 134 (Supplement_1): 409.
https://doi.org/10.1182/blood-2019-121397
Published: 2019