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Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

Computational Approach Based on Independent Drug Action Identifies Clinically Relevant Combinations for Acute Myeloid Leukemia

Xiao Xian Lin, Vedant Sandhu, Christopher A. Eide, Stephen E. Kurtz, Disha Malani, Tom Erkers, Olli Kallioniemi, Jeffrey W Tyner, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 5015.
https://doi.org/10.1182/blood-2023-188731
Published: 2023
Journal Articles

High-Throughput Functional Ex-Vivo Drug Testing and Multi-Omics Profiling in Patients with Acute Myeloid Leukemia

Tom Erkers, PhD, Brinton Seashore-Ludlow, Nona Struyf, Francesco Marabita, Tojo James, Disha Malani, Mattias Vesterlund, Matthias Stalhl, Yudi Pawitan, Sören Lehmann, MD PhD, Päivi Östling, Janne Lehtiö, Olli Kallioniemi
Journal: Blood
Blood (2019) 134 (Supplement_1): 4641.
https://doi.org/10.1182/blood-2019-124332
Published: 2019
Journal Articles

Identification and Clinical Exploration of Individualized Targeted Therapeutic Approaches in Acute Myeloid Leukemia Patients By Integrating Drug Response and Deep Molecular Profiles

Disha Malani, MRes, Ashwini Kumar, MRes, Bhagwan Yadav, PhD, Mika Kontro, MD, Swapnil Potdar, MSc, Samuli Eldfors, MSc, Jani Saarela, Bjørn Tore Gjertsen, Riikka Karjalainen, Tero Aittokallio, Astrid Murumagi, Maija Wolf, PhD, Simon Anders, PhD, Krister Wennerberg, Caroline A Heckman, PhD, Kimmo Porkka, MD PhD, Olli Kallioniemi, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 854.
https://doi.org/10.1182/blood.V130.Suppl_1.854.854
Published: 2017
Journal Articles

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Olli Dufva, Matti Kankainen, PhD, Tiina Kelkka, PhD, Shady Adnan Awad, MD, Nodoka Sekiguchi, MD, Bhagwan Yadav, MSc, Samuli Eldfors, MSc, Heikki Kuusanmäki, MSc, Emma I Andersson, MSc, Disha Malani, MSc, Paavo Pietarinen, MSc, Leena Saikko, Panu E Kovanen, MD PhD, Junji Suzumiya, MD PhD, Ritsuro Suzuki, MD PhD, Young Hyeh Ko, MD, Won Seog Kim, MD PhD, Shih-Sung Chuang, MD, Thomas P. Loughran, Jr., MD, Wing Chung Chan, MD, Koichi Ohshima, MD PhD, Tero Aittokallio, Fumihiro Ishida, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2921.
https://doi.org/10.1182/blood.V128.22.2921.2921
Published: 2016
Journal Articles

Exome Sequencing of Aggressive Natural Killer Cell Leukemia and Drug Profiling Highlight Candidate Driver Pathways in Malignant Natural Killer Cells

Olli Dufva, BMed, Tiina Kelkka, PhD, Shady Awad, MD, Nodoka Sekiguchi, MD, Heikki Kuusanmäki, MSc, Emma I Andersson, MSc, Samuli Eldfors, MSc, Disha Malani, MSc, Paavo Pietarinen, MSc, Leena Saikko, Panu E Kovanen, MD PhD, Junji Suzumiya, MD PhD, Koichi Ohshima, MD PhD, Young Hyeh Ko, MD, Won Seog Kim, MD PhD, Shih-Sung Chuang, MD, Thomas P. Loughran, Jr., MD, Wing C Chan, MD, Fumihiro Ishida, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2015) 126 (23): 700.
https://doi.org/10.1182/blood.V126.23.700.700
Published: 2015
Journal Articles

AML Specific Targeted Drugs Identified By Drug Sensitivity and Resistance Testing: Comparison of Ex Vivo Patient Cells with in Vitro Cell Lines

Disha Malani, MSc, Astrid Murumägi, PhD, Bhagwan Yadav, MSc, Tea Pemovska, MSc, John Patrick Mpindi, MSc, Mika Kontro, MD, Tero Aittokallio, PhD, Caroline A Heckman, PhD, Kimmo Porkka, MD PhD, Krister Wennerberg, PhD, Maija Wolf, PhD, Olli Kallioniemi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2163.
https://doi.org/10.1182/blood.V124.21.2163.2163
Published: 2014
Journal Articles

High-Throughput Drug Sensitivity and Resistance Testing (DSRT) Platform Reveals Novel Candidate Drugs For Advanced Phase BCR-ABL1 -Positive Leukemia

Paavo Pietarinen, MSc, Muntasir Mamun Majumder, MSc, Disha Malani, MSc, Astrid Murumägi, PhD, Tea Pemovska, MSc, Perttu Koskenvesa, MD, Olli Kallioniemi, MD, PhD, Krister Wennerberg, PhD, Caroline A. Heckman, PhD, Satu Mustjoki, MD, PhD, Kimmo Porkka, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2719.
https://doi.org/10.1182/blood.V122.21.2719.2719
Published: 2013
Journal Articles

High-Throughput Ex Vivo Drug Sensitivity and Resistance Testing (DSRT) Integrated with Deep Genomic and Molecular Profiling Reveal New Therapy Options with Targeted Drugs in Subgroups of Relapsed Chemorefractory AML

Caroline A Heckman, PhD, Mika Kontro, MD, Tea Pemovska, MSc, Samuli Eldfors, MSc, Henrik Edgren, MSc, Evgeny Kulesskiy, MSc, Muntasir Mamun Majumder, MSc, Riikka Karjalainen, MSc, Bhagwan Yadav, MSc, Agnieszka Szwajda, MSc, Naga Poojitha Kota Venkata, MSc, Astrid Murumägi, PhD, Disha Malani, MSc, Alun Parsons, MSc, Petteri Hintsanen, PhD, Henrikki Almusa, MSc, Jesús María López Martí, PhD, Pekka Ellonen, MSc, Pirkko Mattila, PhD, Maija Lepistö, MSc, Sonja Lagström, MSc, Minna Suvela, BSc, Satu Mustjoki, MD, PhD, Janna Saarela, MD, PhD, Tero Aittokallio, PhD, Olli Kallioniemi, MD, PhD, Krister Wennerberg, PhD, Kimmo Porkka, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 288.
https://doi.org/10.1182/blood.V120.21.288.288
Published: 2012
Journal Articles

Development of a Cancer Pharmacopeia-Wide Ex-Vivo Drug Sensitivity and Resistance Testing (DSRT) Platform: Identification of MEK and mTOR As Patient-Specific Molecular Drivers of Adult AML and Potent Therapeutic Combinations with Dasatinib

Mika Kontro, MD, Caroline Heckman, PhD, Evgeny Kulesskiy, MSc, Tea Pemovska, MSc, Maxim Bespalov, PhD, Samuli Eldfors, MSc, Elonen Erkki, MD, PhD, Riikka Karjalainen, MSc, Jonathan Knowles, PhD, Disha Malani, MSc, Muntasir Mamun Majumder, MSc, John Patrick Mpindi, MSc, PhD, Astrid Murumägi, PhD, Satu Mustjoki, MD, PhD, Laura Turunen, MSc, Maija Wolf, PhD, Kimmo Porkka, MD, PhD, Krister Wennerberg, PhD, Olli Kallioniemi, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2487.
https://doi.org/10.1182/blood.V118.21.2487.2487
Published: 2011