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Journal Articles

Anti-Inflammatory Response to Anti-Folate and Vitamin D Analog Combination in Large Granular Lymphocyte Leukemia

Katie Moosic, Kristine Olson, David J Feith, Thomas P. Loughran, Jr.

Blood (2023) 142 (Supplement 1): 4194.

https://doi.org/10.1182/blood-2023-190063

Published: 2023

Journal Articles

KLRG1 Depletion Is a Novel Therapeutic Strategy for Patients with Mature T and NK/T-Cell Lymphomas

Blood (2022) 140 (Supplement 1): 2253–2255.

https://doi.org/10.1182/blood-2022-162583

Published: 2022

Journal Articles

Presence of Activating STAT3 Mutations in the CD8+ T Cells of Rheumatoid Arthritis Patients

Katharine B. Moosic, Thomas L. Olson, Mark Freijat, Samara Khalique, Cait E. Hamele, Bryna Shemo, Jesse Boodoo, William Baker, Matthew W. Schmachtenberg, Erika Darrah, Felipe Andrade, Kristine C. Olson, David J. Feith, Donald L. Kimpel, Thomas P. Loughran, Jr.

Blood (2022) 140 (Supplement 1): 11192–11193.

https://doi.org/10.1182/blood-2022-168069

Published: 2022

Journal Articles

The Novel Nano-Formulation of the HDAC Inhibitor, Romidepsin, for the Treatment of Relapsed, Refractory Peripheral T-Cell Lymphoma

Ipsita Pal, Anuradha Illendula, John Sanil Manavalan, Todd P Fox, Owen A. O'Connor, Thomas P. Loughran, Jr., Mark Kester, David J Feith, Enrica Marchi

Blood (2022) 140 (Supplement 1): 8848–8849.

https://doi.org/10.1182/blood-2022-167628

Published: 2022

Journal Articles

Tolinapant, a Non-Peptidomimetic Antagonist of Inhibitors of Apoptosis Proteins, cIAP1/2 and XIAP, in Combination with the Hypomethylating Agents, Azacytidine and Decitabine Are Highly Synergistic in in Vitro Models of T Cell Lymphoma

John Sanil Manavalan, Ipsita Pal, Aidan Pursley, George A. Ward, Tomoko Smyth, Martin Sims, Jason A. Taylor, David J Feith, Thomas P. Loughran, Jr., Owen A. O'Connor, Enrica Marchi

Blood (2022) 140 (Supplement 1): 11552–11553.

https://doi.org/10.1182/blood-2022-169906

Published: 2022

Journal Articles

DR-01, a Non-Fucosylated Anti-CD94 Antibody, Depletes Leukemic Cells in Ex Vivo and In Vivo Models of Large Granular Lymphocyte Leukemia

Kelly Shi, Cindy Tan, Lu Bai, Jennifer Richardson, Andy Deng, Matthias Will, Michael Brehm, Dale Greiner, Leonard Shultz, Antonella Teramo, Renato Zambello, David J Feith, Thomas P. Loughran, Jr., Nenad Tomasevic

Blood (2022) 140 (Supplement 1): 2259–2260.

https://doi.org/10.1182/blood-2022-159242

Published: 2022

Journal Articles

Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia

HeeJin Cheon, Jeffrey C. Xing, Katharine B. Moosic, Johnson Ung, Vivian W. Chan, David S. Chung, Mariella F. Toro, Omar Elghawy, John S. Wang, Cait E. Hamele, Ross C. Hardison, Thomas L. Olson, Su-Fern Tan, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, Jr

Blood (2022) 139 (20): 3058–3072.

https://doi.org/10.1182/blood.2021013164

Published: 2022

Includes: Supplemental data

Journal Articles

Manifestation of Large Granular Lymphocyte Leukemia in Pediatric and Young Adult Population Is Distinct from Older Adult Cohorts

Heejin Cheon, Vivian Chan, Farid Ghamsari, Omar Elghawy, John Wang, David J Feith, Aakrosh Ratan, Thomas P. Loughran, Jr.

Blood (2021) 138 (Supplement 1): 2464.

https://doi.org/10.1182/blood-2021-151172

Published: 2021

Journal Articles

Tolinapant (ASTX660), a Non-Peptidomimetic Antagonist of cIAP1/2 and XIAP, and the HDAC Inhibitor Romidepsin Are Synergistic in in Vitro Models of T Cell Lymphoma

John S Manavalan, Ipsita Pal, Aidan Pursley, George A. Ward, Tomoko Smyth, Martin Sims, David J Feith, Thomas P. Loughran, Jr., Owen A. O'Connor, Enrica Marchi

Blood (2021) 138 (Supplement 1): 4356.

https://doi.org/10.1182/blood-2021-153451

Published: 2021

Journal Articles

Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias

Thomas L. Olson, HeeJin Cheon, Jeffrey C. Xing, Kristine C. Olson, Umadevi Paila, Cait E. Hamele, Yaseswini Neelamraju, Bryna C. Shemo, Matt Schmachtenberg, Shriram K. Sundararaman, Mariella F. Toro, Cheryl A. Keller, Emily A. Farber, Suna Onengut-Gumuscu, Francine E. Garrett-Bakelman, Ross C. Hardison, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, Jr

Blood (2021) 138 (8): 662–673.

https://doi.org/10.1182/blood.2020005831

Published: 2021

Includes: Supplemental data

Journal Articles

Analysis of Genomic Landscape of Large Granular Lymphocyte Leukemia Reveals Etiologic Insights

HeeJin Cheon, BSc, Jeffrey C Xing, BS, David S Chung, BS, Mariella F Toro, BA, Cait E Hamele, BS, Thomas L. Olson, PhD, David J Feith, PhD, Aakrosh Ratan, PhD, Thomas P. Loughran, Jr., MD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-137269

Published: 2020

Journal Articles

Recurrent Mutations of the C-C Motif Chemokine Ligand 22 ( CCL22 ) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

Constance Baer, PhD, Shunsuke Kimura, Ilaria Iacobucci, David J Feith, BS, PhD, Wencke Walter, PhD, Manja Meggendorfer, PhD, Thomas L. Olson, PhD, Aakrosh Ratan, PhD, Martha-Lena Müller, PhD, Mitra Rana, Chunxu Qu, PhD, Ravi Kalathur, Claudia Haferlach, MD, Wolfgang Kern, MD, Thomas P. Loughran, Jr., MD, Charles G Mullighan, MBBS, MD, Torsten Haferlach, MD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-140695

Published: 2020

Journal Articles

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia

Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith, Thomas P. Loughran, Jr

Blood (2018) 131 (25): 2803–2815.

https://doi.org/10.1182/blood-2017-09-808816

Published: 2018

Includes: Supplemental data

Journal Articles

Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia

Francis R LeBlanc, PhD, Jun Yang, MD, John H Heller, B.S., Shubha Dighe, M.S., Alejandro A. Gru, MD, Marya Dunlap-Brown, M.S., Hong-Gang Wang, PhD, David J Feith, PhD, Thomas P Loughran, Jr., MD

Blood (2017) 130 (Supplement 1): 1217.

https://doi.org/10.1182/blood.V130.Suppl_1.1217.1217

Published: 2017

Journal Articles

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tracy Tiffany Wang, BS, Jun Yang, MD, Yong Zhang, PhD, Meili Zhang, PhD, Kevin C Conlon, MD, Yutaka Tagaya, B.M., PhD, Thomas L Olson, PhD, David J Feith, PhD, Nazli Azimi, Pharm.D., PhD, Thomas A. Waldmann, MD, Thomas P Loughran, Jr., MD

Blood (2017) 130 (Supplement 1): 3585.

https://doi.org/10.1182/blood.V130.Suppl_1.3585.3585

Published: 2017

Journal Articles

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Mediates and Sustains NF-κb Constitutive Activation in LGL Leukemia Cells

Jun Yang, MD, Francis R Leblanc, PhD, Shubha Dighe, MS, Susan B. Nyland, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2016) 128 (22): 2762.

https://doi.org/10.1182/blood.V128.22.2762.2762

Published: 2016

Journal Articles

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

Su-Fern Tan, PhD, Xin Liu, MD PhD, Kathleen Broeg, B.S., Todd E. Fox, PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2015) 126 (23): 1246.

https://doi.org/10.1182/blood.V126.23.1246.1246

Published: 2015

Journal Articles

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

Francis Roland LeBlanc, B.S., Hong-Gang Wang, MD PhD, David J. Feith, PhD, Thomas P. Loughran, Jr., MD

Blood (2015) 126 (23): 1288.

https://doi.org/10.1182/blood.V126.23.1288.1288

Published: 2015

NARROW

Anti-Inflammatory Response to Anti-Folate and Vitamin D Analog Combination in Large Granular Lymphocyte Leukemia

KLRG1 Depletion Is a Novel Therapeutic Strategy for Patients with Mature T and NK/T-Cell Lymphomas

Presence of Activating STAT3 Mutations in the CD8+ T Cells of Rheumatoid Arthritis Patients

The Novel Nano-Formulation of the HDAC Inhibitor, Romidepsin, for the Treatment of Relapsed, Refractory Peripheral T-Cell Lymphoma

Tolinapant, a Non-Peptidomimetic Antagonist of Inhibitors of Apoptosis Proteins, cIAP1/2 and XIAP, in Combination with the Hypomethylating Agents, Azacytidine and Decitabine Are Highly Synergistic in in Vitro Models of T Cell Lymphoma

DR-01, a Non-Fucosylated Anti-CD94 Antibody, Depletes Leukemic Cells in Ex Vivo and In Vivo Models of Large Granular Lymphocyte Leukemia

Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia

Manifestation of Large Granular Lymphocyte Leukemia in Pediatric and Young Adult Population Is Distinct from Older Adult Cohorts

Tolinapant (ASTX660), a Non-Peptidomimetic Antagonist of cIAP1/2 and XIAP, and the HDAC Inhibitor Romidepsin Are Synergistic in in Vitro Models of T Cell Lymphoma

Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias

Analysis of Genomic Landscape of Large Granular Lymphocyte Leukemia Reveals Etiologic Insights

Recurrent Mutations of the C-C Motif Chemokine Ligand 22 ( CCL22 ) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia

Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Mediates and Sustains NF-κb Constitutive Activation in LGL Leukemia Cells

Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia

FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia

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American Society of Hematology

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American Society of Hematology

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