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Journal Articles

Beyond CLL Progression: Unveiling Th17 and Th2 T Cell Subsets As Predictors of Pembrolizumab Response in Richter's Transformation

Prajish Iyer, Lu Yang, Sutapa Sinha, Miles Del Busso, Zhi-Zhang Yang, Hyojin Kim, Charla Secreto, Yucai Wang, Neil E. Kay, Stephen M Ansell, Wei Ding, Lili Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1888.
https://doi.org/10.1182/blood-2023-181004
Published: 2023
Journal Articles

COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia

Leisi Zhang, Mingli Li, Anthony KN Chan, Qiao Liu, Hyunjun Kang, Sheela Pangeni Pokharel, Nicole Mattson, Priyanka Singh, Lu Yang, Chun-Wei David Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 581.
https://doi.org/10.1182/blood-2023-188526
Published: 2023
Journal Articles

Mechanistic Elucidation of the Tumor-Promoting Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in B-Cell Receptor Signaling in Mantle Cell Lymphoma

Serene Xavier, Vivian Nguyen, Vishal Khairnar, An Phan, Lu Yang, Michael Nelson, Elizabeth Tseng, Aimin Li, Joo Y Song, Dennis D. Weisenburger, Wing C. Chan, Markus Müschen, Vu N. Ngo
Journal: Blood
Blood (2023) 142 (Supplement 1): 720.
https://doi.org/10.1182/blood-2023-175064
Published: 2023
Journal Articles

TP63 Fusions Drive Enhancer Rewiring, Lymphomagenesis, and Dependence on EZH2

Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Tayla B. Heavican-Foral, Huiyun Liu, Geoffrey M. Nelson, Lu Yang, Renee Chen, Marcus Kenneth Jones, Ran Xu, Ajit Johnson Nirmal, Salvia Jain, Catharine Leahy, Kristen Lynn Jones, Kristen E. Stevenson, Wenchao Wu, Abner Louissaint, Jr., Lydie Debaize, Wing C. Chan, Shannan Ho Sui, Samuel Ng, Andrew L. Feldman, Matthew Meyerson, Karen Adelman, chun-Wei David Chen, Myles Brown, David M. Weinstock
Journal: Blood
Blood (2022) 140 (Supplement 1): 1696–1697.
https://doi.org/10.1182/blood-2022-163368
Published: 2022
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Sara Canovas Nunes, Haiming Xu, Serena De Vita, Andrew Anighoro, Francois Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad E. Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 1199.
https://doi.org/10.1182/blood-2021-147009
Published: 2021
Journal Articles

R-Loop Associated Mitotic Stress Confers Vulnerabilities in Splicing Factor Mutant Leukemia

Martina Cusan, Meiling Jin, Bo Zhang, Mike Fernandez, Aijun Liao, Lu Yang, Yiming Wu, Prajish Iyer, Kevyn Hart, Catherine Gutierrez, Jeremy Stark, Teresa V. Bowman, Catherine J. Wu, Ren-Jang Lin, Lili Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 3713.
https://doi.org/10.1182/blood-2021-151298
Published: 2021
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-140044
Published: 2020
Journal Articles

Pre-Existing T Cell Subsets Determine Anti-PD1 Blockade Response in Richter's Transformation

Prajish Iyer, PhD, Lu Yang, PhD, Zhi-Zhang Yang, PhD, Charla R. Secreto, Sutapa Sinha, PhD, Neil E. Kay, MD, Stephen M. Ansell, MD PhD, Lili Wang, MDPhD, Wei Ding, MD PhD, Hyojin Kim, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-138601
Published: 2020
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Anthony K. N. Chan, PhD, Christopher D. Delaney, Lu Yang, PhD, Wen-Han Chang, PhD, Kazuya Miyashita, PhD, Qiao Liu, MD, Sheela Pangeni Pokharel, MSc, Scott A. Armstrong, MD PhD, Chun-Wei David Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 530.
https://doi.org/10.1182/blood-2019-131467
Published: 2019
Journal Articles

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Xi Qin, Rui Su, PhD, Lu Yang, PhD, Anthony K. N. Chan, PhD, Xiaolan Deng, Ying Qing, Lars Klemm, MS, Markus Müschen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1465.
https://doi.org/10.1182/blood-2019-129849
Published: 2019
Journal Articles

High-Density CRISPR Scan Identifies Functional Regions of DOT1L That Mediate Therapeutic Response in MLL -r Leukemia

Chun-Wei Chen, PhD, Lu Yang, PhD, Xi Wang, PhD, Anthony Chan, PhD, Chris Delaney, Kazuya Miyashita, PhD, Yanchun Guo, MD PhD, Wen-Han Chang, PhD, Sandra Li, Sheela Pokharel, Hongzhi Li, PhD, Yadira Soto-Feliciano, Takayuki Hoshii, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 179.
https://doi.org/10.1182/blood-2018-179
Published: 2018
Journal Articles

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

Christopher J. Ong, Andrew Ming-Lum, Matt Nodwell, Ali Ghanipour, Lu Yang, David E. Williams, Joseph Kim, Loutfig Demirjian, Pooran Qasimi, Jens Ruschmann, Li-Ping Cao, Kewei Ma, Stephen W. Chung, Vincent Duronio, Raymond J. Andersen, Gerald Krystal, Alice L.-F. Mui
Journal: Blood
Blood (2007) 110 (6): 1942–1949.
https://doi.org/10.1182/blood-2007-03-079699
Published: 2007
Includes: Supplemental data
Journal Articles

Phorbol ester stimulates a protein kinase C–mediated agatoxin-TK–sensitive calcium permeability pathway in human red blood cells

Dina A. Andrews, Lu Yang, Philip S. Low
Journal: Blood
Blood (2002) 100 (9): 3392–3399.
https://doi.org/10.1182/blood.V100.9.3392
Published: 2002
Journal Articles

Lysophosphatidic acid opens a Ca ++ channel in human erythrocytes

Lu Yang, Dina A. Andrews, Philip S. Low
Journal: Blood
Blood (2000) 95 (7): 2420–2425.
https://doi.org/10.1182/blood.V95.7.2420
Published: 2000