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Journal Articles

Single-cell transcriptomics reveals erbb-driven clonal evolution and immune evasion in plasma cell leukemia

Free
Tingting Lei, Luyao Shi, Xinli Han, Chi Li, Zongyang Li, Xiaotong Zhang, Kairan Li, Saisai Sun, Lu Yang, Chong Wang, Bian Zhilei, Shujuan Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 7474.
https://doi.org/10.1182/blood-2025-7474
Published: 2025
Journal Articles

Single-cell transcriptomics reveals pathogenic interactions between clonal plasma cells and monocytes in POEMS syndrome

Free
Xinli Han, Chi Li, Luyao Shi, Tingting Lei, Xiaotong Zhang, Zongyang Li, Kairan Li, Saisai Sun, Yan Xu, Lu Yang, Chong Wang, Bian Zhilei, Shujuan Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3929.
https://doi.org/10.1182/blood-2025-3929
Published: 2025
Journal Articles

DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

Free
Xueer Wang, Hongjie Bi, Wei Li, Lili Ren, Honghai Zhang, Lei Dong, Anthony Chan, Lu Yang, Xiaoxu Zhang, Meilin Xue, Hanjun Qin, Xiwei Wu, Johanna ten, Bin Zhang, Ling Li, Mark Wunderlich, James Mulloy, Steven Rosen, Jianjun Chen, Xiaobo Li, Chun-Wei Chen, Rui Su
Journal: Blood
Blood (2025) 146 (Supplement 1): 212.
https://doi.org/10.1182/blood-2025-212
Published: 2025
Journal Articles

Integrated single-cell RNA sequencing and TCR profiling identifies immune drivers of severe early toxicity in CLL patients treated with idelalisib

Free
Saurabh Yadav, Lu Yang, Zunqiu Wang, Binu Kandathilparambil Sasi, Stacey Fernandes, John-Hanson Machado, Samantha Shupe, Ignaty Leshchiner, Lili Wang, Jennifer Brown
Journal: Blood
Blood (2025) 146 (Supplement 1): 2103.
https://doi.org/10.1182/blood-2025-2103
Published: 2025
Journal Articles

Wildtype NUP98 cooperates with NPM1c to drive oncogenic transcription

Free
Sara Gama, Marcel Müller, Hannah González Dammers, Elena Haarer, Sara Peruzzi, José Gonçalves-Dias, Jan-Henning Klusmann, Lu Yang, Renee Chen, Chun-Wei Chen, Stamatis Papathanasiou, Brunangelo Falini, Lorenzo Brunetti, Hannah Uckelmann
Journal: Blood
Blood (2025) 146 (Supplement 1): 865.
https://doi.org/10.1182/blood-2025-865
Published: 2025
Journal Articles

Stepwise leukemogenesis and therapeutic targets revealed in B-cell acute lymphoblastic leukemia driven by PAX5 mutations

Free
Zhilian Jia, Zunsong Hu, Lu Yang, Anthony Chan, Xiaohua Huang, Allen Mao, Ibrahim Aldoss, Lucy Ghoda, Michelle Afkhami, Guido Marcucci, Zhenhua Chen, Jianjun Chen, Chun-Wei Chen, Shai Izraeli, Markus Müschen, Nora Heisterkamp, Zhaohui Gu
Journal: Blood
Blood (2025) 146 (Supplement 1): 139.
https://doi.org/10.1182/blood-2025-139
Published: 2025
Journal Articles

CRISPR-tica.ai: A function-informed generative modeling pipeline for prioritizing drug discovery in AML

Free
Dhvani Vora, Anthony Chan, Sheela Pangeni Pokharel, Qiao Liu, Renee Chen, Bryan Chen, April Chen, Lu Yang, Chun-Wei Chen
Journal: Blood
Blood (2025) 146 (Supplement 1): 277.
https://doi.org/10.1182/blood-2025-277
Published: 2025
Journal Articles

SLC25A21 Correlates with the Prognosis of Adult Acute Myeloid Leukemia through Inhibiting the Growth of Leukemia Cells Via Downregulating CXCL8

Free
Shujuan Wang, Yu Liu, Yan Xu, Qianqian Hao, Luyao Shi, Yufei Chen, Yajun Liu, Mengya Li, Yu Zhang, Tao Li, Yafei Li, Zhongxing Jiang, Yanfang Liu, Chong Wang, Bian Zhilei, Lu Yang, Wenyi Lu
Journal: Blood
Blood (2024) 144 (Supplement 1): 6133.
https://doi.org/10.1182/blood-2024-199630
Published: 2024
Journal Articles

Modeling the Initiation and Progression of Human MLL -Rearranged Precursor B Cell Acute Lymphoblastic Leukemia in Mice

Free
Zhenhua Chen, Lu Yang, Lillian Sau, Zunsong Hu, Meiling Chen, Chengwu Zeng, Chao Shen, Ying Qing, Yuan Che, Dong Wu, Tingting Tang, Zhaoxu Xu, Xin He, Lianjun Zhang, Pu Cheng, Hengyou Weng, Huilin Huang, Zhaohui Gu, Gang Xiao, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 2738.
https://doi.org/10.1182/blood-2024-199829
Published: 2024
Journal Articles

Beyond CLL Progression: Unveiling Th17 and Th2 T Cell Subsets As Predictors of Pembrolizumab Response in Richter's Transformation

Free
Prajish Iyer, Lu Yang, Sutapa Sinha, Miles Del Busso, Zhi-Zhang Yang, Hyojin Kim, Charla Secreto, Yucai Wang, Neil E. Kay, Stephen M Ansell, Wei Ding, Lili Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1888.
https://doi.org/10.1182/blood-2023-181004
Published: 2023
Journal Articles

COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia

Free
Leisi Zhang, Mingli Li, Anthony KN Chan, Qiao Liu, Hyunjun Kang, Sheela Pangeni Pokharel, Nicole Mattson, Priyanka Singh, Lu Yang, Chun-Wei David Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 581.
https://doi.org/10.1182/blood-2023-188526
Published: 2023
Journal Articles

Mechanistic Elucidation of the Tumor-Promoting Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in B-Cell Receptor Signaling in Mantle Cell Lymphoma

Free
Serene Xavier, Vivian Nguyen, Vishal Khairnar, An Phan, Lu Yang, Michael Nelson, Elizabeth Tseng, Aimin Li, Joo Y Song, Dennis D. Weisenburger, Wing C. Chan, Markus Müschen, Vu N. Ngo
Journal: Blood
Blood (2023) 142 (Supplement 1): 720.
https://doi.org/10.1182/blood-2023-175064
Published: 2023
Journal Articles

TP63 Fusions Drive Enhancer Rewiring, Lymphomagenesis, and Dependence on EZH2

Free
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Tayla B. Heavican-Foral, Huiyun Liu, Geoffrey M. Nelson, Lu Yang, Renee Chen, Marcus Kenneth Jones, Ran Xu, Ajit Johnson Nirmal, Salvia Jain, Catharine Leahy, Kristen Lynn Jones, Kristen E. Stevenson, Wenchao Wu, Abner Louissaint, Jr., Lydie Debaize, Wing C. Chan, Shannan Ho Sui, Samuel Ng, Andrew L. Feldman, Matthew Meyerson, Karen Adelman, chun-Wei David Chen, Myles Brown, David M. Weinstock
Journal: Blood
Blood (2022) 140 (Supplement 1): 1696–1697.
https://doi.org/10.1182/blood-2022-163368
Published: 2022
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Free
Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Free
Sara Canovas Nunes, Haiming Xu, Serena De Vita, Andrew Anighoro, Francois Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad E. Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 1199.
https://doi.org/10.1182/blood-2021-147009
Published: 2021
Journal Articles

R-Loop Associated Mitotic Stress Confers Vulnerabilities in Splicing Factor Mutant Leukemia

Free
Martina Cusan, Meiling Jin, Bo Zhang, Mike Fernandez, Aijun Liao, Lu Yang, Yiming Wu, Prajish Iyer, Kevyn Hart, Catherine Gutierrez, Jeremy Stark, Teresa V. Bowman, Catherine J. Wu, Ren-Jang Lin, Lili Wang
Journal: Blood
Blood (2021) 138 (Supplement 1): 3713.
https://doi.org/10.1182/blood-2021-151298
Published: 2021
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Free
Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

Pre-Existing T Cell Subsets Determine Anti-PD1 Blockade Response in Richter's Transformation

Free
Prajish Iyer, PhD, Lu Yang, PhD, Zhi-Zhang Yang, PhD, Charla R. Secreto, Sutapa Sinha, PhD, Neil E. Kay, MD, Stephen M. Ansell, MD PhD, Lili Wang, MDPhD, Wei Ding, MD PhD, Hyojin Kim, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-138601
Published: 2020
Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Free
Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-140044
Published: 2020
Journal Articles

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Free
Anthony K. N. Chan, PhD, Christopher D. Delaney, Lu Yang, PhD, Wen-Han Chang, PhD, Kazuya Miyashita, PhD, Qiao Liu, MD, Sheela Pangeni Pokharel, MSc, Scott A. Armstrong, MD PhD, Chun-Wei David Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 530.
https://doi.org/10.1182/blood-2019-131467
Published: 2019