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Journal Articles

Targeting a Putative Intronic Splicing Silencer Salvages Expression from the Recurrent SBDS C.258+2T>C Mutant Allele in Shwachman-Diamond Syndrome Patient Cells and Mouse Model

Blood (2022) 140 (Supplement 1): 2944–2945.

https://doi.org/10.1182/blood-2022-169379

Published: 2022

Journal Articles

Septin-6 Regulates Murine and Human Hematopoiesis, and Its Dysregulation Is Associated with Pediatric Myelodysplasia

Safa F Mohamad, Meaghan McGuinness, Gabriele Casirati, Alejo E Rodriguez-Fraticelli, Chad E. Harris, Fernando D. Camargo, Pietro Genovese, Eric J Allenspach, David A. Williams

Blood (2022) 140 (Supplement 1): 8588–8589.

https://doi.org/10.1182/blood-2022-163606

Published: 2022

Journal Articles

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Sara Canovas Nunes, Haiming Xu, Serena De Vita, Andrew Anighoro, Francois Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad E. Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A. Williams

Blood (2021) 138 (Supplement 1): 1199.

https://doi.org/10.1182/blood-2021-147009

Published: 2021

Journal Articles

Distinct Genetic Pathways Define Leukemia Predisposition Versus Adaptive Clonal Hematopoiesis in Shwachman-Diamond Syndrome

Alyssa L. Kennedy, MDPhD, Kasiani C. Myers, MD, James Bowman, PhD, Christopher J. Gibson, MD, Gwen M. Muscato, Robert Klein, Kaitlyn Ballotti, Nicholas Camarda, Elissa M. Furutani, MD, Chad E. Harris, MS, Shanshan Liu, PhD, Ashley Galvin, Maggie Malsch, MSN, RN, David C. Dale, MD, John M Gansner, MD PhD, Taizo A. Nakano, MD, Alison A. Bertuch, MD, Adrianna Vlachos, MD, Jeff H. Lipton, MD PhD, Paul Castillo, MD, James Connelly, John Edwards, MD, Nobuko Hijiya, MD, Richard Ho, MD, Inga Hofmann, MD, James N Huang, MD, Sioban B. Keel, MD, Adam J. Lamble, MD, Bonnie W Lau, MD PhD, Kelly J. Walkovich, MD, Maxim Norkin, MD, Wendy Stock, MD, Steffen Boettcher, Christian Brendel, PhD, Elliot Stieglitz, MD, Mark D. Fleming, MD DPhil, Stella M. Davies, PhD MBBS, MRCP, Edie A. Weller, Chris Bahl, PhD, Scott L. Carter, PhD, Akiko Shimamura, MD PhD, R. Coleman Lindsley, MD PhD

Blood (2020) 136 (Supplement 1): 35–36.

https://doi.org/10.1182/blood-2020-137125

Published: 2020

Journal Articles

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix

Pavankumar N. G. Reddy, Maria Radu, Ke Xu, Jenna Wood, Chad E. Harris, Jonathan Chernoff, David A. Williams

Blood (2016) 127 (16): 1967–1975.

https://doi.org/10.1182/blood-2016-01-693572

Published: 2016

Journal Articles

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

Ganesan Keerthivasan, Yang Mei, Baobing Zhao, Ling Zhang, Chad E. Harris, Juehua Gao, Ashley A. Basiorka, Matthew J. Schipma, James McElherne, Jing Yang, Amit K. Verma, Andrea Pellagatti, Jacqueline Boultwood, Alan F. List, David A. Williams, Peng Ji

Blood (2014) 124 (5): 780–790.

https://doi.org/10.1182/blood-2014-01-552463

Published: 2014

Includes: Supplemental data

Journal Articles

Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo

Pavankumar N.G. Reddy, PhD, Jenna Wood, Chad E Harris, Ke Xu, Meaghan McGuinness, Maria Radu, MD PhD, Rachelle Kosoff, Jonathan Chernoff, MD, PhD, David A. Williams, MD

Blood (2013) 122 (21): 2419.

https://doi.org/10.1182/blood.V122.21.2419.2419

Published: 2013

Journal Articles

Aberrant Overexpression Of CD14 In Granulocytes Sensitizes Innate Immune Response In mDia1 Heterozygous Myelodysplastic Syndromes

Ganesan Keerthivasan, MBBS, MD, Baobing Zhao, PhD, Chad E Harris, Ling Zhang, MD, Juehua Gao, M.D., Ph.D., James McElherne, Jing Yang, Ashley A Basiorka, Matthew Schipma, Jacqueline Boultwood, Amit Verma, Alan List, MD, David A. Williams, MD, Peng Ji, MD, PhD

Blood (2013) 122 (21): 1557.

https://doi.org/10.1182/blood.V122.21.1557.1557

Published: 2013

Journal Articles

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

Adrienne M. Dorrance, Serena De Vita, Maria Radu, Pavankumar N. G. Reddy, Meaghan K. McGuinness, Chad E. Harris, Ronald Mathieu, Steven W. Lane, Rachelle Kosoff, Michael D. Milsom, Jonathan Chernoff, David A. Williams

Blood (2013) 121 (13): 2474–2482.

https://doi.org/10.1182/blood-2012-10-460709

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial

Raffaele Renella, MD, PhD, Aleksej Perlov, Chad E Harris, Daniel E. Bauer, MD, PhD, Jian Xu, PhD, Swaroopa Guda, PhD, Michael D. Milsom, PhD, Stuart H. Orkin, MD, David A. Williams, MD

Blood (2012) 120 (21): 753.

https://doi.org/10.1182/blood.V120.21.753.753

Published: 2012

Journal Articles

Vav1 Deficiency Differentially Affects Engraftment of Fetal Hematopoietic Organs During Development Compared with Adult Marrow After Transplantation

Serena De Vita, MD, PhD, Chad E Harris, Raffaele Renella, MD, PhD, Ronald Mathieu, Meaghan McGuinness, David A. Williams, MD

Blood (2012) 120 (21): 1212.

https://doi.org/10.1182/blood.V120.21.1212.1212

Published: 2012

Journal Articles

Signaling and cytoskeletal requirements in erythroblast enucleation

Diamantis G. Konstantinidis, Suvarnamala Pushkaran, James F. Johnson, Jose A. Cancelas, Stefanos Manganaris, Chad E. Harris, David A. Williams, Yi Zheng, Theodosia A. Kalfa

Blood (2012) 119 (25): 6118–6127.

https://doi.org/10.1182/blood-2011-09-379263

Published: 2012

Journal Articles

Overcoming reprogramming resistance of Fanconi anemia cells

Lars U. W. Müller, Michael D. Milsom, Chad E. Harris, Rutesh Vyas, Kristina M. Brumme, Kalindi Parmar, Lisa A. Moreau, Axel Schambach, In-Hyun Park, Wendy B. London, Kelly Strait, Thorsten Schlaeger, Alexander L. DeVine, Elke Grassman, Alan D'Andrea, George Q. Daley, David A. Williams

Blood (2012) 119 (23): 5449–5457.

https://doi.org/10.1182/blood-2012-02-408674

Published: 2012

Includes: Supplemental data

Journal Articles

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

Benjamin Mizukawa, Junping Wei, Mahesh Shrestha, Mark Wunderlich, Fu-Sheng Chou, Andrea Griesinger, Chad E. Harris, Ashish R. Kumar, Yi Zheng, David A. Williams, James C. Mulloy

Blood (2011) 118 (19): 5235–5245.

https://doi.org/10.1182/blood-2011-04-351817

Published: 2011

Journal Articles

Very High Expression of MGMT(P140K) Paradoxically Impairs Proliferation, In Vivo Selection and Protection of Transduced Hematopoietic Stem Cells.

Michael D. Milsom, PhD, Chad E. Harris, Axel Schambach, MD, PhD, Emily Broun, Moran Jerabek-Willemsen, Christopher Baum, MD, Thomas Moritz, MD, Geoffrey Margison, PhD, Jürgen Thomale, PhD, David A. Williams, MD

Blood (2007) 110 (11): 2588.

https://doi.org/10.1182/blood.V110.11.2588.2588

Published: 2007

Journal Articles

The Sooner the Better: Rapid Transduction Enhances the Engraftment/Selection of Gene Corrected Fanconi Anemia HSC.

Lars U.W. Muller, MD, Michael Milsom, Ph.D., Chad E. Harris, Jeff Bailey, David A. Williams, MD

Blood (2007) 110 (11): 194.

https://doi.org/10.1182/blood.V110.11.194.194

Published: 2007

Journal Articles

Rac GTPases Are Potential Therapeutic Targets in p210-BCR-ABL-Induced Myeloproliferative Disease (MPD).

Emily K. Thomas, PhD, Jose A. Cancelas, MD, PhD, Heedon Chae, PhD, Adrienne D. Cox, PhD, Patricia J. Keller, PhD, Danilo Perrotti, MD, PhD, Paolo Neviani, Brian J. Druker, MD, Yi Zheng, PhD, Chad E. Harris, David A. Williams, MD

Blood (2007) 110 (11): 465.

https://doi.org/10.1182/blood.V110.11.465.465

Published: 2007

Journal Articles

Rho GTPase Rac1 is critical for neutrophil migration into the lung

Marie-Dominique Filippi, Kathleen Szczur, Chad E. Harris, Pierre-Yves Berclaz

Blood (2006) 109 (3): 1257–1264.

https://doi.org/10.1182/blood-2006-04-017731

Published: 2006

Journal Articles

The RHO GTPASE CDC42 Regulator CDC42GAP Plays a Critical Role in Neutrophil Migration Via Podosome-Like Formation.

Marie-Dominique Filippi, PhD, Haiming Xu, MS, Jason Towe, MS, Chad E. Harris, MS, Kathleen Szczur, MS, Lei Wang, MS, Simon Atkinson, PhD, Yi Zheng, PhD, David A. Williams, MD

Blood (2004) 104 (11): 651.

https://doi.org/10.1182/blood.V104.11.651.651

Published: 2004

NARROW

Targeting a Putative Intronic Splicing Silencer Salvages Expression from the Recurrent SBDS C.258+2T>C Mutant Allele in Shwachman-Diamond Syndrome Patient Cells and Mouse Model

Septin-6 Regulates Murine and Human Hematopoiesis, and Its Dysregulation Is Associated with Pediatric Myelodysplasia

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Distinct Genetic Pathways Define Leukemia Predisposition Versus Adaptive Clonal Hematopoiesis in Shwachman-Diamond Syndrome

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo

Aberrant Overexpression Of CD14 In Granulocytes Sensitizes Innate Immune Response In mDia1 Heterozygous Myelodysplastic Syndromes

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial

Vav1 Deficiency Differentially Affects Engraftment of Fetal Hematopoietic Organs During Development Compared with Adult Marrow After Transplantation

Signaling and cytoskeletal requirements in erythroblast enucleation

Overcoming reprogramming resistance of Fanconi anemia cells

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

Very High Expression of MGMT(P140K) Paradoxically Impairs Proliferation, In Vivo Selection and Protection of Transduced Hematopoietic Stem Cells.

The Sooner the Better: Rapid Transduction Enhances the Engraftment/Selection of Gene Corrected Fanconi Anemia HSC.

Rac GTPases Are Potential Therapeutic Targets in p210-BCR-ABL-Induced Myeloproliferative Disease (MPD).

Rho GTPase Rac1 is critical for neutrophil migration into the lung

The RHO GTPASE CDC42 Regulator CDC42GAP Plays a Critical Role in Neutrophil Migration Via Podosome-Like Formation.

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American Society of Hematology

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American Society of Hematology

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