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Journal Articles

Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets

Shailaja Hegde, Huzoor Akbar, Ashley M. Wellendorf, Shawnagay Nestheide, James F. Johnson, Xueheng Zhao, Kenneth D. Setchell, Yi Zheng, Jose A. Cancelas

Blood (2024) 144 (16): 1732–1746.

https://doi.org/10.1182/blood.2023021453

Published: 2024

Includes: Supplemental data

Journal Articles

Circadian Rhythms Metabolically Regulate Bone Marrow Retained Primitive Hematopoietic Stem Cell Size and Function

Priyasmita Chakrabarti, Nicola K. Wilson, Abhishek K. Singh, Iwo Kucinski, Lizeth-Alejandra Ordonez-Moreno, Sony Sharma, Sarah J. Kinston, Montaser B. Haddad, Orit Kollet, Ekaterina Petrovich-Kopitman, Avik Choudhuri, Leonard I. Zon, Jose A. Cancelas, John E. Dick, Stephanie Xie, Bertie Göttgens, Tsvee Lapidot

Blood (2023) 142 (Supplement 1): 2672.

https://doi.org/10.1182/blood-2023-186260

Published: 2023

Journal Articles

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis

María Piedad Menéndez-Gutiérrez, Jesús Porcuna, Ramesh Nayak, Ana Paredes, Haixia Niu, Vanessa Núñez, Aditi Paranjpe, Manuel J. Gómez, Anukana Bhattacharjee, Daniel J. Schnell, Fátima Sánchez-Cabo, John S. Welch, Nathan Salomonis, Jose A. Cancelas, Mercedes Ricote

Blood (2023) 141 (6): 592–608.

https://doi.org/10.1182/blood.2022016832

Published: 2023

Includes: Supplemental data

Journal Articles

Dominant-Negative VPS4A Mutations Causing Congenital Dyserythropoietic Anemia Disrupt Iron Trafficking of Terminal Erythropoiesis

Katie Seu, Aikaterini Voulgaridou, Maria Stewart, Jessica Meznarich, Clarissa Johnson, Harald Junge, Bryan Mackenzie, Lionel Blanc, Jose A. Cancelas, Theodosia A. Kalfa

Blood (2022) 140 (Supplement 1): 8190–8191.

https://doi.org/10.1182/blood-2022-170843

Published: 2022

Journal Articles

Precision transfusion medicine: a new spin

Jose A. Cancelas

Blood (2022) 140 (15): 1661–1663.

https://doi.org/10.1182/blood.2022018080

Published: 2022

Journal Articles

SERF1 Is Required for G-CSF Resistance of Start-Codon Mutant ELANE Granulocytic Precursors

Ramesh C Nayak, Lisa Trump, Sana Emberesh, Yarim Lee, Abhishek K Singh, Ashley M Wellendorf, Marshall S. Horwitz, Theodosia A. Kalfa, Carolyn Lutzko, Jose A. Cancelas

Blood (2021) 138 (Supplement 1): 433.

https://doi.org/10.1182/blood-2021-150899

Published: 2021

Journal Articles

Scribble Is a Negative Regulator of Interferon-I Dependent Notch1 Activation in Adult Hematopoietic Stem Cells and Progenitors

Abhishek K Singh, Mark J Althoff, Saimul Islam, Ashley M Wellendorf, Jose A. Cancelas

Blood (2021) 138 (Supplement 1): 299.

https://doi.org/10.1182/blood-2021-151046

Published: 2021

Journal Articles

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

Karin Golan, Abhishek K. Singh, Orit Kollet, Mayla Bertagna, Mark J. Althoff, Eman Khatib-Massalha, Ekaterina Petrovich-Kopitman, Ashley M. Wellendorf, Hassan Massalha, Smadar Levin-Zaidman, Tali Dadosh, Breanna Bohan, Mruniya V. Gawali, Biplab Dasgupta, Tsvee Lapidot, Jose A. Cancelas

Blood (2020) 136 (23): 2607–2619.

https://doi.org/10.1182/blood.2020005399

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Mitochondrial Fate of Regenerative Hematopoietic Stem Cells Is Sequentially Controlled By Two Specific Conformations of Connexin-43

Abhishek K Singh, PhD, Ashley M Wellendorf, B.S., Breanna Bohan, B.S., Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Ashwini S. Hinge, PhD, Marie-Dominique Filippi, PhD, Jose A. Cancelas, MD

Blood (2020) 136 (Supplement 1): 32–33.

https://doi.org/10.1182/blood-2020-141676

Published: 2020

Journal Articles

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate

Mark J. Althoff, Ramesh C. Nayak, Shailaja Hegde, Ashley M. Wellendorf, Breanna Bohan, Marie-Dominique Filippi, Mei Xin, Q. Richard Lu, Hartmut Geiger, Yi Zheng, Maria T. Diaz-Meco, Jorge Moscat, Jose A. Cancelas

Blood (2020) 136 (16): 1824–1836.

https://doi.org/10.1182/blood.2019004113

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Tatsuro Yoshida, PhD, Angelo D'Alessandro, PhD, Xiaoyun Fu, PhD, Travis Nemkov, PhD, Davide Stefanoni, Michael Dioguardi, BS, Neeta Rugg, Shawnagay Nestheide, BS, William Iselin, BA, Andrew Dunham, PhD, James C. Zimring, MD PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4994.

https://doi.org/10.1182/blood-2019-125961

Published: 2019

Journal Articles

Long-Term Hypoxic/Hypocapnic Storage of Red Blood Cells Results in Amelioration of Lesion Hallmarks and Increased In Vivo recovery at 24 Hours Post-Transfusion

Jose A Cancelas, MD, F. Bernadette West, MD, Matthew Karaffin, MD, Tatsuro Yoshida, PhD, Neeta Rugg, Pamela Whitley, MS, MT(ASCP), SBB, Michael Dioguardi, BS, Scott Brooks, CCRP, Michael Wellington, William Iselin, BA, Andrew Dunham, PhD

Blood (2019) 134 (Supplement_1): 4995.

https://doi.org/10.1182/blood-2019-128559

Published: 2019

Journal Articles

Disruption of the Akt-FoxO Axis As a Safeguard Mechanism for the Hematopoietic Stem Cell Compartment during Chronic Metabolic Stress

Vinothini Govindarajah, PhD, Jung-Mi Lee, PhD, Michael Solomon, Bryan Goddard, Ramesh C. Nayak, PhD, Jose A Cancelas, MD, Damien Reynaud

Blood (2019) 134 (Supplement_1): 1201.

https://doi.org/10.1182/blood-2019-127222

Published: 2019

Journal Articles

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

Shailaja N Hegde, PhD, Huzoor Akbar, PhD, Shawnagay Nestheide, BS, Ashley M Wellendorf, B.S., Breanna Bohan, James F Johnson, Yi Zheng, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 99.

https://doi.org/10.1182/blood-2019-125359

Published: 2019

Journal Articles

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Nicolas Nassar, PhD, Shailaja N Hegde, PhD, Anjelika Gasilina, Mark Wunderlich, MS, Gurdat Premnauth, Edward Merino, PhD, Yuan Lin, PhD, Reza Ahmadian, PhD, Yi Zheng, PhD, Benjamin Mizukawa, Lisa Privette Vinnedge, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4647.

https://doi.org/10.1182/blood-2019-130250

Published: 2019

Journal Articles

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Abhishek K Singh, PhD, Karin Golan, PhD, Mark J Althoff, BS, Ekaterina Petrovich-Kopitman, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Mayla Bertagna, MSc, Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Tsvee Lapidot, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 872.

https://doi.org/10.1182/blood-2018-99-118292

Published: 2018

Journal Articles

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Blood (2018) 132 (Supplement 1): 639.

https://doi.org/10.1182/blood-2018-99-118663

Published: 2018

Journal Articles

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Shailaja N Hegde, PhD, Mark J Althoff, BS, Ramesh C. Nayak, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Gang Huang, PhD, Yi Zheng, PhD, Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 551.

https://doi.org/10.1182/blood-2018-99-118919

Published: 2018

Journal Articles

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Swarnava Roy, PhD, Parul Rai, MD, Marthe-Sandrine Eiymo Mwa Mpollo, PhD, Kyung-Hee Chang, PhD, Tilat Rizvi, Loberg Anastacia, Bruce J. Aronow, PhD, Tadashi Inagami, PhD, David Witte, MD, Jose A Cancelas, MD PhD, Punam Malik, MD

Blood (2017) 130 (Supplement 1): 440.

https://doi.org/10.1182/blood.V130.Suppl_1.440.440

Published: 2017

Journal Articles

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

Mark J Althoff, BS, Ramesh C. Nayak, PhD, Shailaja Hegde, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2017) 130 (Supplement 1): 710.

https://doi.org/10.1182/blood.V130.Suppl_1.710.710

Published: 2017

NARROW

Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets

Circadian Rhythms Metabolically Regulate Bone Marrow Retained Primitive Hematopoietic Stem Cell Size and Function

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis

Dominant-Negative VPS4A Mutations Causing Congenital Dyserythropoietic Anemia Disrupt Iron Trafficking of Terminal Erythropoiesis

Precision transfusion medicine: a new spin

SERF1 Is Required for G-CSF Resistance of Start-Codon Mutant ELANE Granulocytic Precursors

Scribble Is a Negative Regulator of Interferon-I Dependent Notch1 Activation in Adult Hematopoietic Stem Cells and Progenitors

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

Mitochondrial Fate of Regenerative Hematopoietic Stem Cells Is Sequentially Controlled By Two Specific Conformations of Connexin-43

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Long-Term Hypoxic/Hypocapnic Storage of Red Blood Cells Results in Amelioration of Lesion Hallmarks and Increased In Vivo recovery at 24 Hours Post-Transfusion

Disruption of the Akt-FoxO Axis As a Safeguard Mechanism for the Hematopoietic Stem Cell Compartment during Chronic Metabolic Stress

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

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American Society of Hematology

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ASH Publications

American Society of Hematology

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