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Leonard I. Zon
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Journal Articles

Generation of Functional iPSC-Derived CAR-T Cells for Cancer Immunotherapy Via G9a/GLP Inhibition

Free
Ran Jing, Marcelo Falchetti, Tianxiao Han, Mohamad Najia, Luca Hensch, Eleanor Meader, Martin Kononov, Stephanie Wang, Caroline Kubaczka, Edroaldo Lummertz Da Rocha, Robert Grant Rowe, Thorsten M. Schlaeger, Marcela Maus, Trista E. North, Leonard I. Zon, George Q. Daley
Journal: Blood
Blood (2024) 144 (Supplement 1): 2043.
https://doi.org/10.1182/blood-2024-208634
Published: 2024
Journal Articles

Transcription Factor Programming of Human iPSC-Derived Sinusoidal Vascular Endothelial Cells Enhances Co-Cultured Hematopoietic Stem and Progenitor Cell Transplantation

Free
Tianxiao Han, Rajesh D. Gunage, Ran Jing, Olivia Stockard, Alexandra F. Corbin, Luca Hensch, Yang Tang, Kenny Chen, Song Yang, Yi Zhou, George Q. Daley, Thorsten M. Schlaeger, Leonard I. Zon
Journal: Blood
Blood (2024) 144 (Supplement 1): 820.
https://doi.org/10.1182/blood-2024-208453
Published: 2024
Journal Articles

Hematopoietic Stem Cells Supporting Fetal Erythropoiesis Are Differentially Regulated By Small and Large Ribosomal Subunits

Free
Yuefeng Tang, Te Ling, Rashid Mehmood, Mushran Khan, Julien Papoin, James Palis, Laurie A. Steiner, Sébastien Durand, Leonard I. Zon, Senthil Velan Bhoopalan, Mitchell J Weiss, Jeffrey Michael Lipton, Naomi Taylor, Patrick G. Gallagher, Mohandas Narla, John D. Crispino, Lionel Blanc
Journal: Blood
Blood (2024) 144 (Supplement 1): 195.
https://doi.org/10.1182/blood-2024-210699
Published: 2024
Journal Articles

Chemical Modulation of ELF1 Binding to RUNX1 Target Genes Leads to Increased Hematopoietic Stem Cell Self-Renewal

Free
Anne L. Robertson, Lu Yue, Avik Choudhuri, Caroline Kubaczka, Samuel J. Wattrus, Joseph Mandelbaum, Serine Avagyan, Song Yang, Rebecca J. Freeman, Victoria Chan, Megan C. Blair, George Q. Daley, Leonard I. Zon
Journal: Blood
Blood (2024) 144 (Supplement 1): 4043.
https://doi.org/10.1182/blood-2024-208498
Published: 2024
Journal Articles

Asxl1- mutant Dominant Clones Have an Erythropoietic Lineage Deficiency through a Disturbed Epigenetic Landscape

Free
Serine Avagyan, Song Yang, Brandon Gheller, Leonard I. Zon
Journal: Blood
Blood (2023) 142 (Supplement 1): 4063.
https://doi.org/10.1182/blood-2023-178343
Published: 2023
Journal Articles

Exposure of hiPSC-Derived Mature Megakaryocytes to Vincristine Boosts Platelet Biogenesis in Vitro

Free
Yasuo Harada, Emiri Nakamura, Trevor Bingham, Leonard I. Zon, George Q. Daley, Andrew Frelinger, Koji Eto, Thorsten M. Schlaeger
Journal: Blood
Blood (2023) 142 (Supplement 1): 1292.
https://doi.org/10.1182/blood-2023-185254
Published: 2023
Journal Articles

m6A Mediated Ribostasis of RNA Stress Granule Assembly Governs Blood Development and Regeneration

Free
Rajesh D. Gunage, Leonard I. Zon
Journal: Blood
Blood (2023) 142 (Supplement 1): 143.
https://doi.org/10.1182/blood-2023-186560
Published: 2023
Journal Articles

In Vivo Reprogramming of Adult Liver Sinusoidal Vascular Endothelial Cells into a Hematopoietic Stem and Progenitor Cell Niche

Free
Tianxiao Han, Rajesh D. Gunage, Ran Jing, Alexandra F. Corbin, Kenny Zhi Ming Chen, Yang Tang, Olivia Stockard, Song Yang, Yi Zhou, George Q. Daley, Thorsten M. Schlaeger, Leonard I. Zon
Journal: Blood
Blood (2023) 142 (Supplement 1): 4071.
https://doi.org/10.1182/blood-2023-180300
Published: 2023
Journal Articles

TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation

Free
Marlies P. Rossmann, Song Yang, Brian J. Abraham, Ying Wang, Richard A. Young, Siegfried Hekimi, Leonard I. Zon
Journal: Blood
Blood (2023) 142 (Supplement 1): 8.
https://doi.org/10.1182/blood-2023-184853
Published: 2023
Journal Articles

Circadian Rhythms Metabolically Regulate Bone Marrow Retained Primitive Hematopoietic Stem Cell Size and Function

Free
Priyasmita Chakrabarti, Nicola K. Wilson, Abhishek K. Singh, Iwo Kucinski, Lizeth-Alejandra Ordonez-Moreno, Sony Sharma, Sarah J. Kinston, Montaser B. Haddad, Orit Kollet, Ekaterina Petrovich-Kopitman, Avik Choudhuri, Leonard I. Zon, Jose A. Cancelas, John E. Dick, Stephanie Xie, Bertie Göttgens, Tsvee Lapidot
Journal: Blood
Blood (2023) 142 (Supplement 1): 2672.
https://doi.org/10.1182/blood-2023-186260
Published: 2023
Journal Articles

Loss of nr4a1 abrogates Fitness of asxl1- mutant Hematopoietic Clones

Free
Serine Avagyan, Jonathan E Henninger, William P. Mannherz, Meeta Mistry, Song Yang, Margaret C. Weber, Jessica Moore, Leonard I. Zon
Journal: Blood
Blood (2021) 138 (Supplement 1): 3272.
https://doi.org/10.1182/blood-2021-149731
Published: 2021
Journal Articles

Single-Cell Transcriptional Profiling of Zebrafish Hematopoiesis Offers Insight into Early Lymphocyte Development and Reveals Novel Immune Cell Populations

Free
Sara A. Rubin, Chloé S. Baron, Alexandra F. Corbin, Song Yang, Leonard I. Zon
Journal: Blood
Blood (2021) 138 (Supplement 1): 4294.
https://doi.org/10.1182/blood-2021-146374
Published: 2021
Journal Articles

Cellular Barcoding of HSCs during Development Reveals Long-Term Persistence of T Cell Progenitor Clones in the Thymus

Free
Sara A. Rubin, Chloé S. Baron, PhD, Song P. Yang, PhD, Aaron McKenna, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-136837
Published: 2020
Journal Articles

Cxcl8/PKC Signaling in the Endothelial Cell Niche Regulates Long-Term Hematopoietic Stem Cell Fate

Free
Jami L Shaffer, B.S., Donn L Calkins, BS, Emily M Teets, B.S., Muhammad Faisal, William Deruelle, Elliott J. Hagedorn, PhD, Julie R. Perlin, PhD, Serine Avagyan, MD PhD, Leonard I. Zon, MD, Bradley W Blaser, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38.
https://doi.org/10.1182/blood-2020-141609
Published: 2020
Journal Articles

Mosaic Mutagenesis In Vivo Reveals Mutant Blood Stem Cells Intrinsically Resistant to Inflammatory Mediators in Clonal Hematopoiesis

Free
Serine Avagyan, MD PhD, Jonathan E Henninger, William P. Mannherz, Meeta Mistry, Song P. Yang, PhD, Margaret Weber, Jessica Moore, Leonard I. Zon, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27.
https://doi.org/10.1182/blood-2020-140903
Published: 2020
Journal Articles

Ing4 Suppresses Quiescence and Inflammation in Hematopoietic Stem Cells

Free
Zanshe Thompson, MS, Melanie Rodriguez, MS, Georgina Anderson, MS, MA, Seth Gabriel, MS, Vera Binder, MD, Leonard I. Zon, MD, Katie L Kathrein, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16.
https://doi.org/10.1182/blood-2020-143388
Published: 2020
Journal Articles

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Free
Masato Miyata, Nynke Gillemans, Dorit Hockman, Jeroen A. A. Demmers, Jan-Fang Cheng, Jun Hou, Matti Salminen, Christopher A. Fisher, Stephen Taylor, Richard J. Gibbons, Jared J. Ganis, Leonard I. Zon, Frank Grosveld, Eskeatnaf Mulugeta, Tatjana Sauka-Spengler, Douglas R. Higgs, Sjaak Philipsen
Journal: Blood
Blood (2020) 136 (3): 269–278.
https://doi.org/10.1182/blood.2020004826
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Transcription Factor Induction of Ectopic Vascular Blood Stem Cell Niches In Vivo

Free
Elliott J. Hagedorn, PhD, Julie R. Perlin, PhD, Rebecca J. Freeman, BS, Clara Mao, BS, Inés Fernández-Maestre, BS, Madeleine L. Daily, B.S., Christopher R. D'Amato, B.S., Samuel J. Wattrus, B.S., Tianxiao Han, BS, Michael J. Fairchild, PhD, Raquel Riquelme, Brian Li, B.S., Shelby E. Redfield, B.S., Samantha H. Collins, B.S., Asher Lichtig, BS, Song Yang, PhD, Yi Zhou, Balvir Kunar, Jesus M Gomez-Salinero, PhD, Theresa T. Dinh, PhD, Junliang Pan, MD PhD, Karoline Holler, B.S., Eugene Butcher, Alexander Van Oudenaarden, Shahin Rafii, MD, Jan Philipp Junker, PhD, Leonard I Zon, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 525.
https://doi.org/10.1182/blood-2019-127219
Published: 2019
Journal Articles

Cxcl8 Expands Hematopoietic Stem and Progenitor Cells and Alters Their Interaction with the Endothelial Niche

Free
Donn L Calkins, BS, Jami L Shaffer, B.S., Emily M Teets, B.S., Alex M Belardo, Serine Avagyan, MD PhD, Leonard I Zon, MD, Bradley W Blaser, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 527.
https://doi.org/10.1182/blood-2019-126151
Published: 2019
Journal Articles

Ing4 Regulates Stress Hematopoiesis and Represses Self-Renewal in Multipotent Progenitor Cells

Free
Zanshe Thompson, MS, Melanie Rodriguez, BS, Seth Gabriel, MS, Georgina Anderson, MS, Vera Binder, MD, Leonard I Zon, MD, Katie L Kathrein, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 724.
https://doi.org/10.1182/blood-2019-129054
Published: 2019