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Huzoor Akbar
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Journal Articles

Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets

Shailaja Hegde, Huzoor Akbar, Ashley M. Wellendorf, Shawnagay Nestheide, James F. Johnson, Xueheng Zhao, Kenneth D. Setchell, Yi Zheng, Jose A. Cancelas
Journal: Blood
Blood (2024) 144 (16): 1732–1746.
https://doi.org/10.1182/blood.2023021453
Published: 2024
Includes: Supplemental data
Journal Articles

Structure-Activity Relationship Analysis of Analogs of Rhosin, a RhoA Inhibitor, Reveals a New Generation of Improved Antiplatelet Agents

Akhila Dandamudi, William Seibel, Huzoor Akbar, Yi Zheng
Journal: Blood
Blood (2021) 138 (Supplement 1): 3989.
https://doi.org/10.1182/blood-2021-153108
Published: 2021
Journal Articles

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

Shailaja N Hegde, PhD, Huzoor Akbar, PhD, Shawnagay Nestheide, BS, Ashley M Wellendorf, B.S., Breanna Bohan, James F Johnson, Yi Zheng, PhD, Jose A Cancelas, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 99.
https://doi.org/10.1182/blood-2019-125359
Published: 2019
Journal Articles

RhoA and Rac1 Gtpases Differentially Regulate Agonist-Receptor Mediated ROS Generation in Platelets

Huzoor Akbar, PhD, Xin Duan, PhD, Saima Saleem, PhD, Ashley Kuenzi Davis, MS, Yi Zheng, PhD
Journal: Blood
Blood (2014) 124 (21): 2763.
https://doi.org/10.1182/blood.V124.21.2763.2763
Published: 2014
Journal Articles

Specific Pharmacologic Targeting of Rho GTPases Rac1, Cdc42 and RhoA Reveals Their Differential and Critical Roles In Regulation of Platelet Activation

Huzoor Akbar, PhD, Xun Shang, PhD, Rehana Perveen, PhD, Kevin Funk, MS, Mark Berryman, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2010) 116 (21): 2019.
https://doi.org/10.1182/blood.V116.21.2019.2019
Published: 2010
Journal Articles

Genetic and Pharmacologic Evidence Shows That Cdc42 GTPase Plays a Central Role in the Regulation of Both GPVI- and Non-GPVI-Dependent Activation of Platelets.

Huzoor Akbar, PhD, Kevin Funk, MS, Mark Berryman, PhD, Joshua Raines, BS, Rehana Perveen, PhD, Xun Shang, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2009) 114 (22): 2997.
https://doi.org/10.1182/blood.V114.22.2997.2997
Published: 2009
Journal Articles

Rac2 GTPase Plays a Critical Role in Platelet Adhesion as Well as in Sustenance and Perpetuation of Platelet Aggregation.

Huzoor Akbar, PhD, James F. Johnson, David A. Williams, MD, Yi Zheng, PhD
Journal: Blood
Blood (2004) 104 (11): 3523.
https://doi.org/10.1182/blood.V104.11.3523.3523
Published: 2004
Journal Articles

Mechanism of human platelet activation by endotoxic glycolipid-bearing mutant Re595 of Salmonella minnesota

S Timmons, Huzoor-Akbar, J Grabarek, M Kloczewiak, J Hawiger
Journal: Blood
Blood (1986) 68 (5): 1015–1023.
https://doi.org/10.1182/blood.V68.5.1015.1015
Published: 1986