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Journal Articles

Leveraging Transcriptomic Data to Study Erythromyeloblastic Island (EMBI) Macrophages: Using Spic-GFP As a Marker for Embi Macrophages

Laurel Romano, Athina Ntoumaziou, Jason C Gardner, Maria Stewart, Robert Paulson, Nathan Salomonis, Lionel Blanc, Katie Seu, Theodosia A. Kalfa

Blood (2023) 142 (Supplement 1): 3832.

https://doi.org/10.1182/blood-2023-187162

Published: 2023

Journal Articles

A Novel Beta Globin Frameshift Mutation Causing Autosomal Dominant Beta Thalassemia

Lisa Bilston, Kelsey Uminski, Theodosia A. Kalfa, Ammar Husami, M. Dawn Goodyear, Natalia Rydz

Blood (2023) 142 (Supplement 1): 1105.

https://doi.org/10.1182/blood-2023-187014

Published: 2023

Journal Articles

Irf5 Expression in Macrophages Contributes to Iron Regulation within Erythromyeloblastic Islands

Rachel Josselsohn, Anshul Vagrecha, Margaret LaPan, Julien Papoin, Jonah Kamen, Young Min Cho, Riaz Rao, Laurel Romano, Nathan Salomonis, Theodosia A. Kalfa, Lionel Blanc, Betsy J. Barnes

Blood (2023) 142 (Supplement 1): 920.

https://doi.org/10.1182/blood-2023-189421

Published: 2023

Journal Articles

Inducible Knockout of Codanin-1: An Adult Mouse Model of Congenital Dyserythropoietic Anemia Type-I

Corbin R Azucenas, Maria Stewart, Aikaterini Voulgaridou, Katie Seu, Theodosia A. Kalfa

Blood (2023) 142 (Supplement 1): 2450.

https://doi.org/10.1182/blood-2023-187075

Published: 2023

Journal Articles

Rapid Assessment of Hemoglobin-Oxygen Dissociation

Zoe Sekyonda, Cissy Kityo, Yasmin Elgammal, Theodosia A. Kalfa, Ozan Akkus, Umut A. Gurkan

Blood (2023) 142 (Supplement 1): 2270.

https://doi.org/10.1182/blood-2023-187503

Published: 2023

Journal Articles

Effects of L-Glutamine on Biomarkers of Response in Sickle Cell Disease: A Pharmacokinetics-Pharmacodynamics Analysis

Alina Sadaf, Min Dong, Jennifer Korpik, Amanda Pfeiffer, Theodosia A. Kalfa, Teresa S. Latham, Alexander A. Vinks, Russell E. Ware, Charles T. Quinn

Blood (2023) 142 (Supplement 1): 1145.

https://doi.org/10.1182/blood-2023-180312

Published: 2023

Journal Articles

Erythrocyte Disorders Mimicking Congenital Dyserythropoietic Anemia Based on Bone Marrow Pathology Exposed By Genetic Evaluation

Jacopo Ceolan, Katie Seu, Athina Ntoumaziou, Yasmin Elgammal, Sana Emberesh, Lisa Bilston, Donald Richards, Kathryn E. Dickerson, Satheesh Chonat, Natalia Rydz, Carolyn Lutzko, Ammar Husami, Wenying Zhang, Theodosia A. Kalfa

Blood (2023) 142 (Supplement 1): 2459.

https://doi.org/10.1182/blood-2023-189140

Published: 2023

Journal Articles

Congenital Dyserythropoietic Anemia Type II: An Update from the Congenital Dyseryhtropoietic Anemia Registry of North America (CDAR)

Yasmin Elgammal, Mary Risinger, Ammar Husami, Joseph Walden, Sweta Gupta, Niketa C. Shah, James Boyer, Yasmina L. Abajas, Michael Winstead, David W. Miller, Viviana Vidal-Anaya, Adrianna Vlachos, Ashutosh Lal, Arthur K. Ritchey, Robert Lorsbach, Wenying Zhang, Theodosia A. Kalfa, Omar Niss

Blood (2023) 142 (Supplement 1): 1079.

https://doi.org/10.1182/blood-2023-189389

Published: 2023

Journal Articles

De Novo Germline DHX38 Variant Associated with Alternative Splicing of Multiple Transcripts in Iron-Related Pathways in a Patient with Atypical Congenital Dyserythropoietic Anemia with Ring Sideroblasts

Aikaterini Voulgaridou, Yasmin Elgammal, Ammar Husami, Sana Emberesh, Katie Seu, Mahesh Ramamoorthy, Lisa Trump, Nathaniel Barasa, Adam S. Nelson, Robert B. Lorsbach, Laurel Romano, Nathan A. Salomonis, Wenying Zhang, Carolyn Lutzko, Theodosia A. Kalfa

Blood (2022) 140 (Supplement 1): 1234–1235.

https://doi.org/10.1182/blood-2022-166509

Published: 2022

Journal Articles

Dominant-Negative VPS4A Mutations Causing Congenital Dyserythropoietic Anemia Disrupt Iron Trafficking of Terminal Erythropoiesis

Katie Seu, Aikaterini Voulgaridou, Maria Stewart, Jessica Meznarich, Clarissa Johnson, Harald Junge, Bryan Mackenzie, Lionel Blanc, Jose A. Cancelas, Theodosia A. Kalfa

Blood (2022) 140 (Supplement 1): 8190–8191.

https://doi.org/10.1182/blood-2022-170843

Published: 2022

Journal Articles

Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis

Laurel Romano, Katie G. Seu, Julien Papoin, David E. Muench, Diamantis Konstantinidis, André Olsson, Katrina Schlum, Kashish Chetal, Joel Anne Chasis, Narla Mohandas, Betsy J. Barnes, Yi Zheng, H. Leighton Grimes, Nathan Salomonis, Lionel Blanc, Theodosia A. Kalfa

Blood (2022) 140 (14): 1621–1634.

https://doi.org/10.1182/blood.2022015724

Published: 2022

Includes: Supplemental data

Journal Articles

Overexpression of Human TLR8 Causes Fatal Anemia in SLE-Prone Mice By Altering the Bone Marrow Erythropoietic Niche

Anne Davidson, Naomi Maria, Julien Papoin, Chirag Raparia, Zeguo Sun, Weijia Zhang, Theodosia A. Kalfa, Robert Paulson, Lionel Blanc

Blood (2021) 138 (Supplement 1): 1989.

https://doi.org/10.1182/blood-2021-145465

Published: 2021

Journal Articles

Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study

Theodosia A. Kalfa, Marilyn J. Telen, Santosh L. Saraf, R. Clark Clark Brown, Katie Giger Seu, Sandra K. Larkin, Maria D. Ribadeneira, Patricia Schroeder, Eric Wu, Patrick Kelly, Frans A. Kuypers

Blood (2021) 138 (Supplement 1): 8.

https://doi.org/10.1182/blood-2021-147078

Published: 2021

Journal Articles

Trial in Progress: A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of the PKR Activator Etavopivat (FT-4202) in Patients with Thalassemia or Sickle Cell Disease

Ashutosh Lal, R. Clark Clark Brown, Thomas D. Coates, Theodosia A. Kalfa, Janet L. Kwiatkowski, Julie Brevard, Von Potter, Ken W. Wood, Sujit Sheth

Blood (2021) 138 (Supplement 1): 4162.

https://doi.org/10.1182/blood-2021-145752

Published: 2021

Journal Articles

Activation of Pyruvate Kinase-R with Etavopivat (FT-4202) Is Well Tolerated, Improves Anemia, and Decreases Intravascular Hemolysis in Patients with Sickle Cell Disease Treated for up to 12 Weeks

R. Clark Clark Brown, Santosh L. Saraf, Kimberly Cruz, Modupe Idowu, Theodosia A. Kalfa, James Geib, Sanjeev Forsyth, Patricia Schroeder, Eric Wu, Patrick Kelly, Marilyn J. Telen

Blood (2021) 138 (Supplement 1): 9.

https://doi.org/10.1182/blood-2021-147091

Published: 2021

Journal Articles

SERF1 Is Required for G-CSF Resistance of Start-Codon Mutant ELANE Granulocytic Precursors

Ramesh C Nayak, Lisa Trump, Sana Emberesh, Yarim Lee, Abhishek K Singh, Ashley M Wellendorf, Marshall S. Horwitz, Theodosia A. Kalfa, Carolyn Lutzko, Jose A. Cancelas

Blood (2021) 138 (Supplement 1): 433.

https://doi.org/10.1182/blood-2021-150899

Published: 2021

Journal Articles

Rapid and Automated Quantitation of Dense Red Blood Cells: A Robust Biomarker of Therapeutic Response to Early Initiation of Hydroxyurea in Young Children with Sickle Cell Anemia

Alina Sadaf, MD, Charles T. Quinn, MD, Jennifer B Korpik, Amanda Pfeiffer, BS, MA, Mary Reynaud, MA, MT(ASCP), Omar Niss, MD, Punam Malik, MD, Russell E. Ware, MD PhD, Theodosia A. Kalfa, MD PhD, Patrick T. McGann, MD MS

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-137070

Published: 2020

Journal Articles

Ex-Vivo FT-4202 Treatment Improves Hemoglobin Oxygen Affinity and Membrane Health in Red Blood Cells of Patients with Hemoglobin SS and Hemoglobin SC Disease Irrespective of Prior Hydroxyurea Use

Diamantis G. Konstantinidis, PhD BSc, Rose Fessler, Katie Giger Seu, PhD, Bhargav Patel, Jennifer B Korpik, Keertik Fulzele, PhD, Sylvie Guichard, Theodosia A. Kalfa, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139714

Published: 2020

Journal Articles

Angiotensin Signaling Is Essential for Stress Erythropoiesis but Results in Retention of Dysfunctional Mitochondria in Erythrocytes That Generate Excessive Reactive Oxygen Species

Parul Rai, MDMBBS, Swarnava Roy, PhD, Diamantis G. Konstantinidis, PhD BSc, Sithara Raju Ponny, MS, Marthe-sandrine Eiymo Mwa Mpollo, PhD, Archana Shrestha, Theodosia A. Kalfa, MD PhD, Punam Malik, MD

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-139980

Published: 2020

Journal Articles

Increased Hydroxyurea Prescribing Practices over Ten Years with Improved Clinical Outcomes in Children with Sickle Cell Anemia: A Single Center's Experience

Kristine Anne Karkoska, MD, Kevin E Todd, Jr., MD, Kelly Clapp, NP, Lynette Fenchel, NP, Theodosia A. Kalfa, MD PhD, Punam Malik, MD, Omar Niss, MD, Charles T. Quinn, MD, Russell E. Ware, MD PhD, Patrick T. McGann, MD MS

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-138754

Published: 2020

NARROW

Leveraging Transcriptomic Data to Study Erythromyeloblastic Island (EMBI) Macrophages: Using Spic-GFP As a Marker for Embi Macrophages

A Novel Beta Globin Frameshift Mutation Causing Autosomal Dominant Beta Thalassemia

Irf5 Expression in Macrophages Contributes to Iron Regulation within Erythromyeloblastic Islands

Inducible Knockout of Codanin-1: An Adult Mouse Model of Congenital Dyserythropoietic Anemia Type-I

Rapid Assessment of Hemoglobin-Oxygen Dissociation

Effects of L-Glutamine on Biomarkers of Response in Sickle Cell Disease: A Pharmacokinetics-Pharmacodynamics Analysis

Erythrocyte Disorders Mimicking Congenital Dyserythropoietic Anemia Based on Bone Marrow Pathology Exposed By Genetic Evaluation

Congenital Dyserythropoietic Anemia Type II: An Update from the Congenital Dyseryhtropoietic Anemia Registry of North America (CDAR)

De Novo Germline DHX38 Variant Associated with Alternative Splicing of Multiple Transcripts in Iron-Related Pathways in a Patient with Atypical Congenital Dyserythropoietic Anemia with Ring Sideroblasts

Dominant-Negative VPS4A Mutations Causing Congenital Dyserythropoietic Anemia Disrupt Iron Trafficking of Terminal Erythropoiesis

Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis

Overexpression of Human TLR8 Causes Fatal Anemia in SLE-Prone Mice By Altering the Bone Marrow Erythropoietic Niche

Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study

Trial in Progress: A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of the PKR Activator Etavopivat (FT-4202) in Patients with Thalassemia or Sickle Cell Disease

Activation of Pyruvate Kinase-R with Etavopivat (FT-4202) Is Well Tolerated, Improves Anemia, and Decreases Intravascular Hemolysis in Patients with Sickle Cell Disease Treated for up to 12 Weeks

SERF1 Is Required for G-CSF Resistance of Start-Codon Mutant ELANE Granulocytic Precursors

Rapid and Automated Quantitation of Dense Red Blood Cells: A Robust Biomarker of Therapeutic Response to Early Initiation of Hydroxyurea in Young Children with Sickle Cell Anemia

Ex-Vivo FT-4202 Treatment Improves Hemoglobin Oxygen Affinity and Membrane Health in Red Blood Cells of Patients with Hemoglobin SS and Hemoglobin SC Disease Irrespective of Prior Hydroxyurea Use

Angiotensin Signaling Is Essential for Stress Erythropoiesis but Results in Retention of Dysfunctional Mitochondria in Erythrocytes That Generate Excessive Reactive Oxygen Species

Increased Hydroxyurea Prescribing Practices over Ten Years with Improved Clinical Outcomes in Children with Sickle Cell Anemia: A Single Center's Experience

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American Society of Hematology

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American Society of Hematology

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