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Journal Articles

Genomic Profiles and Associated Survival Prognosticators in Black Patients with Acute Myeloid Leukemia

Andrew Stiff, Deedra Nicolet, Maarten Fornerod, Ben Kelly, Katherine Miller, Krzysztof Mrózek, Isaiah Boateng, Bailee Nicole Kain, Elizabeth Garfinkle, Eileen Y Hu, Saranga Wijeratne, Gregory Wheeler, Christopher J. Walker, Jill Buss, Adrienne Heyrosa, Helee Desai, Andrea Laganson, Yazan Abu-Shihab, Hasan Abaza, Alice Mims, Christopher C. Oakes, Bethany L Mundy-Bosse, Andrew J Carroll, Bayard L Powell, Jonathan E Kolitz, Richard Stone, Electra D Paskett, Ross L Levine, Kamal Menghrajani, Debyani Chakravarty, Michael F. Berger, Nathan Salomonis, Daniel Bottomly, Shannon K McWeeney, Jeffrey W Tyner, John C. Byrd, H. Leighton Grimes, Elaine R Mardis, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 837.
https://doi.org/10.1182/blood-2023-181876
Published: 2023
Journal Articles

The Mechanism of Therapy Resistance By Lineage Plasticity in AML and How to Overcome It

Sean Walulik, Sarai Dean, Eric J Vick, Xiaoqin Zhu, Mark Wunderlich, Chih-Hsing Chou, Kwangmin Choi, H. Leighton Grimes, Daniel T. Starczynowski, Linde A. Miles, Andrew Volk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1410.
https://doi.org/10.1182/blood-2023-186180
Published: 2023
Journal Articles

Downregulation of Mitochondrial Complex II (MC II) in Myelodysplastic Syndromes

Maiko Sezaki, Michihiro Hashimoto, Asumi Yokota, Nathan Salomonis, H. Leighton Grimes, Gang Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4583.
https://doi.org/10.1182/blood-2023-186829
Published: 2023
Journal Articles

Single-Cell Multiomics Reveal Hypomethylating Agent Partially Restores Hematopoiesis in a LR-MDS Patient at the Cost of Leukemic Transformation

Xuan Zhang, Baobao (Annie) Song, Mohammad Daud Khan, Kyle Ferchen, Chih-Hsing Chou, Guangyuan Li, Amy E. DeZern, Gabriel Ghiaur, Stephanie Halene, Nathan Salomonis, H. Leighton Grimes
Journal: Blood
Blood (2022) 140 (Supplement 1): 9759–9760.
https://doi.org/10.1182/blood-2022-169300
Published: 2022
Journal Articles

Identification and Isolation of Hematopoietic Stem Cells and Progenitors with Discrete Developmental Gene Expression Programs

Kyle Ferchen, Baobao (Annie) Song, Chih-Hsing Chou, Xuan Zhang, Nathan Salomonis, H. Leighton Grimes
Journal: Blood
Blood (2022) 140 (Supplement 1): 2856.
https://doi.org/10.1182/blood-2022-169525
Published: 2022
Journal Articles

Sex-Associated Differences in Frequencies and Outcome Prognostication of Recurrent Molecular Features in Adults with Acute Myeloid Leukemia (AML) (AMLCG, CALGB [Alliance])

Michael P. Ozga, Deedra Nicolet, Krzysztof Mrózek, Selen Yilmaz, Jessica Kohlschmidt, Karilyn T. Larkin, James S. Blachly, Christopher C. Oakes, Jill Buss, Christopher J. Walker, Shelley Orwick, Vindi Jurinovic, Maja Rothenberg-Thurley, Annika Maria Dufour, Stephanie Schneider, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard Josef Woermann, Wolfgang Hiddemann, Jan Braess, Marion Subklewe, Karsten Spiekermann, Andrew J. Carroll, William G. Blum, Bayard L. Powell, Jonathan E. Kolitz, Joseph O. Moore, Robert James Mayer, Richard M. Stone, Geoffrey L. Uy, Wendy Stock, Klaus H. Metzeler, H. Leighton Grimes, John C. Byrd, Nathan Salomonis, Tobias Herold, Alice S. Mims, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2022) 140 (Supplement 1): 936–939.
https://doi.org/10.1182/blood-2022-165395
Published: 2022
Journal Articles

Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations

Michael Solomon, Baobao (Annie) Song, Vinothini Govindarajah, Samantha Good, James Bartram, Jose Cancelas, Marie-Dominique Filippi, Nathan Salomonis, H. Leighton Grimes, Damien Reynaud
Journal: Blood
Blood (2022) 140 (Supplement 1): 1981–1982.
https://doi.org/10.1182/blood-2022-159781
Published: 2022
Journal Articles

Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation

Patricia A. Colom Diaz, Chih-Hsing Chou, Jayna J Mistry, Nathan Salomonis, Mohammad Daud Khan, H. Leighton Grimes, Jennifer J Trowbridge
Journal: Blood
Blood (2022) 140 (Supplement 1): 9103–9104.
https://doi.org/10.1182/blood-2022-163355
Published: 2022
Journal Articles

Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis

Laurel Romano, Katie G. Seu, Julien Papoin, David E. Muench, Diamantis Konstantinidis, André Olsson, Katrina Schlum, Kashish Chetal, Joel Anne Chasis, Narla Mohandas, Betsy J. Barnes, Yi Zheng, H. Leighton Grimes, Nathan Salomonis, Lionel Blanc, Theodosia A. Kalfa
Journal: Blood
Blood (2022) 140 (14): 1621–1634.
https://doi.org/10.1182/blood.2022015724
Published: 2022
Includes: Supplemental data
Journal Articles

Divisional Memory Drives Hematopoietic Stem Cell Functional Diversity

James Bartram, Baobao (Annie) Song, Juying Xu, Nathan Salomonis, H. Leighton Grimes, Marie-Dominique Filippi
Journal: Blood
Blood (2021) 138 (Supplement 1): 20.
https://doi.org/10.1182/blood-2021-153296
Published: 2021
Journal Articles

Neutrophil Development and Neutropenia

H. Leighton Grimes, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): SCI4.
https://doi.org/10.1182/blood-2020-133029
Published: 2020
Journal Articles

In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis

Jizhou Zhang, Qingqing Wu, PhD, Courtney Johnson, BS, Giang Pham, PhD, Jeremy M. Kinder, Immanuel Kwok, Keith Leong, André Olsson, MS, PhD, Anastasiya Slaughter, BA, Margot Lindsay May, BS, Benjamin Weinhaus, BS, Angelo D'Alessandro, James Douglas Engel, PhD, Jean X. Jiang, PhD, J.Matthew Koffron, Lei Huang, PhD, Lai Guang Ng, Sing Sing Way, MDPhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD, Daniel Lucas-Alcaraz, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–39.
https://doi.org/10.1182/blood-2020-143123
Published: 2020
Journal Articles

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Lanzhu Yue, Vasundhara Sharma, Nathan P. Horvat, Afua A. Akuffo, Matthew S. Beatty, Cem Murdun, Christelle Colin, Julia M. R. Billington, William E. Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia N. Darville, Javier Pinilla-Ibarz, Gary W. Reuther, Kenneth L. Wright, Chiara Conti, Jennifer Y. Lee, Xiaozhang Zheng, Pui Yee Ng, Matthew W. Martin, C. Gary Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo M. Sotomayor, Zonghong Shao, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2020) 135 (3): 191–207.
https://doi.org/10.1182/blood.2019895326
Published: 2020
Includes: Supplemental data
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors

Jizhou Zhang, Qingqing Wu, PhD, Courtney Johnson, BS, André Olsson, MS, PhD, Anastasiya Slaughter, BA, Margot Lindsay May, BS, Benjamin Weinhaus, BS, Emily Bowers, PhD, James Douglas Engel, PhD, Jean X. Jiang, PhD, Sherry L. Abboud-Werner, PhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD, Daniel Lucas-Alcaraz, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 528.
https://doi.org/10.1182/blood-2019-128809
Published: 2019
Journal Articles

V2 Trial: A Phase I Study of Venetoclax Combined with CPX-351 for Children, Adolescents and Young Adults with Relapsed or Refractory Acute Leukemia

Laura Agresta, MD, Maureen M O'Brien, MD, Kana Mizuno, PhD, Robin Norris, MD MS, MPH, Erin H. Breese, MD PhD, Christine L Phillips, MD, Karen Burns, MD, Benjamin Mizukawa, Lynn Lee, MD, Adam Lane, PhD, Robert B. Lorsbach, MD PhD, Thomas D. Ryan, MD PhD, Pankaj B. Desai, PhD, Alexander A. Vinks, PharmD, PhD, H. Leighton Grimes, PhD, John P Perentesis, Michael J. Absalon, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3830.
https://doi.org/10.1182/blood-2019-121514
Published: 2019
Journal Articles

A Prognostic Human Splicing Signature That Precurses Leukemia

Meenakshi Venkatasubramanian, BS, Xiaoting Chen, PhD, Kashish Chetal, MS, Aishwarya Kulkarni, MS, Kasiani C. Myers, MD, Matthew T. Weirauch, PhD, H. Leighton Grimes, PhD, Nathan Salomonis, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 877.
https://doi.org/10.1182/blood-2018-99-115000
Published: 2018
Journal Articles

The Erythro-Myeloblastic Island (EMBI): A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis

Katie Giger Seu, PhD, Laurel Romano, Julien Papoin, MS, Edward David Muench, Diamantis Konstantinidis, PhD BSc, André Olsson, MSc, PhD, Kashish Chetal, MS, Joel Anne Chasis, MD, Mohandas Narla, DSc, Nathan Salomonis, PhD, H Leighton Grimes, PhD, Lionel Blanc, PhD, Theodosia A. Kalfa, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 842.
https://doi.org/10.1182/blood-2018-99-118728
Published: 2018
Journal Articles

SKI Controls MDS-Associated Chronic TGFb Signaling, Aberrant Splicing, and Stem Cell Fitness

David Muench, BS, Kyle Ferchen, BS, Chinavenmeni S. Velu, PhD, Kith Pradhan, PhD, Kashish Chetal, MS, Clemencia Colmenares, PhD, Amit Verma, MD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2018-99-119441
Published: 2018
Journal Articles

Neutropenia-Associated Mutations Differentially Impact Developmental Cell-States

David Muench, BS, Kyle Ferchen, BS, Giang Pham, PhD, Somchai Chutipongtanate, MDPhD, Pankaj Dwivedi, PhD, Stuart Hay, Kashish Chetal, MS, Jayati Mookerjee-Basu, PhD, Kejian Zhang, MD MBA, Kasiani C. Myers, MD, Kristopher Nazor, PhD, Kenneth D Greis, PhD, Dietmar J Kappes, PhD, Sing Sing Way, MDPhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 18.
https://doi.org/10.1182/blood-2018-99-116549
Published: 2018